BAFILOMYCIN B1

Product Name: BAFILOMYCIN B1
CAS No.: 88899-56-3
Chemical Name: BAFILOMYCIN B1
Synonyms: CID 74030053;BAFILOMYCIN B1;BAFILOMYCIN B1 USP/EP/BP;ino)carbonyl)-2-methoxy-24-methyl-;bafilomycin b1from streptomyces sp.;BafilomycinB1fromStreptomycesgriseus;BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO- MYCES SPECIES;hygrolidin,37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclopenten-1-yl)am;37-De(carboxy)-2-demethyl-37-[[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]carbonyl]-2-methoxy-24-methylhygrolidin;2-Butenoic acid, 4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-, (2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethy...
CBNumber: CB4312754
Molecular Formula: C44H65NO13
Formula Weight: 815.99
MOL File: 88899-56-3.mol

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BAFILOMYCIN B1 Property

storage temp.: −20°C
solubility: DMSO: Soluble; Methanol: Unstable
form: powder or crystals
color: faint yellow to yellow
BRN: 4640118
Stability:: Hygroscopic
InChIKey: KFUFLYSBMNNJTF-JUFZODOZSA-N
SMILES: C1(O)(C(C)C(O)C(C)C2OC(=O)C(OC)=CC(C)=CC(C(O)C(C)CC(C)=CC=CC2OC)C)OC(C(C)C(OC(=O)/C=C/C(=O)NC2=C(O)CCC2=O)C1)C(C)C |c:28,t:14,17,26|

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Safety

Hazard Codes: T+
Risk Statements: 26/27/28
Safety Statements: 36/37/39-45
RIDADR: UN 3462 6.1/PG 1
WGK Germany: 3
RTECS: NG8841000
F: 10-21
HazardClass: 3
HS Code: 2941900000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 11707
Product name: Bafilomycin B1 from Streptomyces sp.
Purity: ≥80% (HPLC)
Packaging: 1mg
Price: $218
Updated: 2022/05/15

Cayman Chemical

Product number: 14005
Product name: Bafilomycin B1
Purity: ≥97%
Packaging: 100μg
Price: $41
Updated: 2024/03/01

Cayman Chemical

Product number: 14005
Product name: Bafilomycin B1
Purity: ≥97%
Packaging: 1mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 14005
Product name: Bafilomycin B1
Purity: ≥97%
Packaging: 5mg
Price: $505
Updated: 2024/03/01

Usbiological

Product number: B0003-71
Product name: Bafilomycin B1
Packaging: 1mg
Price: $368
Updated: 2021/12/16

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BAFILOMYCIN B1 Chemical Properties,Usage,Production

Description

Bafilomycin B₁ is a fungal metabolite that has been found in Streptomyces and has diverse biological activities. It inhibits the activity of rat liver lysosomal vacuolar H⁺-ATPase (V-ATPase) in a concentration-dependent manner. Bafilomycin B₁ (10-1,000 nM) induces autophagosome accumulation in MCF-7 cells. It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) when used at a concentration of 1 nM. Bafilomycin B₁ reduces viral genome copy numbers in the culture supernatant of Vero E6 cells infected with H1N1 influenza A.

Uses

Bafilomycin B1 is a member of a potent family of macrocyclic lactones. Bafilomycin B1 shares the same mode of action and activity as its more accessible A1 analogue. Bafilomycin B1 is broadly active against bacteria, fungi, insects, nematodes and protozoans. Bafilomycin B1 has attracted interest as a potential agent for treating osteoporosis.

IC 50

Macrolide

References

[1] E J BOWMAN K A A Siebers. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1988, 85 21: 7972-7976. DOI: 10.1073/pnas.85.21.7972
[2] A YAMAMOTO. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.[J]. Cell structure and function, 1998, 23 1: 33-42. DOI: 10.1247/csf.23.33
[3] JOHN J SHACKA Kevin A R Barbara J Klocke. Autophagy, bafilomycin and cell death: the “a-B-cs” of plecomacrolide-induced neuroprotection.[J]. Autophagy, 2006, 2 3: 228-230. DOI: 10.4161/auto.2703
[4] EMANUELE PAPINI . Cell vacuolization induced by Helicobacter pylori: Inhibition by bafilomycins A1, B1, C1 and D[J]. Fems Microbiology Letters, 1993, 113 2: Pages 155-159.
[5] GAVIN CARR. Bafilomycins Produced in Culture by Streptomyces spp. Isolated from Marine Habitats Are Potent Inhibitors of Autophagy?[J]. Journal of Natural Products , 2009, 73 3: 422-427. DOI: 10.1021/np900632r
[6] XI XIE. Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp.[J]. Journal of Natural Products , 2021, 84 2: 537-543. DOI: 10.1021/acs.jnatprod.0c01243

BAFILOMYCIN B1 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAFILOMYCIN B1 Suppliers

China 54 Germany 2 India 1 Switzerland 2 United Kingdom 7 United States 13 Global 79

Shanghai Forever Synthesis Co.,Ltd

Tel: 18096642264
Email: sales01@foreversyn.com
Country: China
ProdList: 996
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9941
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3061
Advantage: 58

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View Lastest Price from BAFILOMYCIN B1 manufacturers

Dideu Industries Group Limited

Product: BAFILOMYCIN B1 88899-56-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-19

88899-56-3, BAFILOMYCIN B1Related Search:

B-1 Doxycycline BAFILOMYCIN B2 BAFILOMYCIN A1 (DRY ICE) Bafilomycin A2 Bafilomycin C2 Bafilomycin A1 from Streptomycesgriseus, 10 ug,BAFILOMYCIN A1, 98+%,BAFILOMYCIN A1 95%,BAFILOMYCIN A1, STREPTOMYCES GRISEUS,BAFILOMYCIN A1 Bafilomycin D2' Bafilomycin E Bafilomycin D1 BAFILOMYCIN C1 bafilomycin D BAFILOMYCIN B1 MONOHYDRATE BAFILOMYCIN B2 FROM STREPTOMYCES GRISEUS

BAFILOMYCIN B1

BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO- MYCES SPECIES

BafilomycinB1fromStreptomycesgriseus

bafilomycin b1from streptomyces sp.

hygrolidin,37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclopenten-1-yl)am

ino)carbonyl)-2-methoxy-24-methyl-

37-De(carboxy)-2-demethyl-37-[[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]carbonyl]-2-methoxy-24-methylhygrolidin

2-Butenoic acid, 4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-, (2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethy...

BAFILOMYCIN B1 USP/EP/BP

CID 74030053

88899-56-3

C44H65NO13

Antibiotics

Antibiotics A-F

Antibiotics A to Z

BioChemical

Antibiotic

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A - KAntibiotics

Antibacterial

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Antibiotics A-FAntibiotics

Antibiotics by Application

AntifungalAntibiotics

Antineoplastic and Immunosuppressive AntibioticsAntibiotics

Chemical Structure Class

Inhibits an EnzymeAntibiotics

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Spectrum of Activity