BAFILOMYCIN A1

ChemicalBook > CAS DataBase List > BAFILOMYCIN A1

Product Name: BAFILOMYCIN A1
CAS No.: 88899-55-2
Chemical Name: BAFILOMYCIN A1
Synonyms: CS-1163;afilomycin A1;BAFILOMYCIN A1;BAFILOMYCIN A1 95%;Bafilomycin A1,95%;BAFILOMYCIN A1, 98+%;Bafilomycin A1(Baf-A1);BAFILOMYCIN A1 USP/EP/BP;BAFILOMYCIN A1, STREPTOMYCES GRISEUS;BafilomycinA1fromStreptomycesgriseus
CBNumber: CB3743951
Molecular Formula: C35H58O9
Formula Weight: 622.83
MOL File: 88899-55-2.mol

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BAFILOMYCIN A1 Property

Melting point:: >106°C (dec.)
Boiling point:: 582.86°C (rough estimate)
Density: 1.0594 (rough estimate)
refractive index: 1.5000 (estimate)
RTECS: RN9781000
Flash point:: 87℃
storage temp.: -20°C
solubility: Soluble in DMSO (up to 5 mg/ml, with warming).
form: Powder or Solid
pka: 12.66±0.70(Predicted)
color: White to off-white
Water Solubility: Soluble in methanol, ethanol, acetone and chloroform. Insoluble in water.
BRN: 4730700
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
RIDADR: 3172
WGK Germany: 3
F: 10
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29419090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B1793
Product name: Bafilomycin A1 from Streptomyces griseus
Purity: ≥90% (HPLC)
Packaging: 2μg
Price: $86.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1661
Product name: Bafilomycin A1 Ready Made Solution
Purity: 0.16?mMinDMSO,fromStreptomycesgriseus
Packaging: 0.1ml
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: B1793
Product name: Bafilomycin A1 from Streptomyces griseus
Purity: ≥90% (HPLC)
Packaging: 10μg
Price: $210
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.08409
Product name: InSolution Bafilomycin A1, ≥97% by HPLC - CAS 88899-55-2 - Calbiochem
Purity: A 100 μM (15 μg/241 μL) sterile-filtered solution of Bafilomycin A1,
Packaging: 15μG
Price: $280
Updated: 2024/03/01

Sigma-Aldrich

Product number: 196000
Product name: Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem
Purity: Bafilomycin A1, CAS 88899-55-2, acts as a highly potent and specific inhibitor of vacuolar-type H+-ATPase (Ki = 500 pM). Blocks the fusion of autophagosome with lysosome.
Packaging: 10μG
Price: $201
Updated: 2024/03/01

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BAFILOMYCIN A1 Chemical Properties,Usage,Production

Description

Bafilomycin A₁ is a fungal metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H⁺-ATPases (V-ATPases; K_i = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na⁺/K⁺-, Ca²⁺-, and H⁺-ATPases. Bafilomycin A₁ (100 nM) inhibits autophagosome maturation and protein degradation in H-4-II-E cells. It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) but not chloroquine-induced inhibition of macroautophagy. Bafilomycin A₁ (100 nM) reduces viral yield in the culture supernatant of Vero E6 and Huh7 cells, as well as HEK293T cells expressing human angiotensin-converting enzyme 2 (ACE2), infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It also reduces lung RNA copy numbers and viral pneumonia in ACE2 transgenic mice infected with SARS-CoV-2 when administered at a dose of 0.1 mg/kg.

Chemical Properties

white to off-white powder

Uses

Bafilomycin A1 is a member of a potent family of macrocyclic lactones with broad spectrum biological activity, including activity against bacteria, yeast, fungi, nematodes, insects and tumour cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type ATPase.

Uses

A macrolide antibiotic and potent and selective inhibitor of vacuolar-type (v-type) H+ ATPase

Uses

Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases.It is used as an antibacterial, antifungal, antineoplastic and an immunosuppressive. It prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes and is a macrolide antibiotic and potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase).

Definition

ChEBI: The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus.

General Description

A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H⁺-ATPase (V-type; K_i = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).

Biological Activity

Highly potent, selective inhibitor of vacuolar H + -ATPases (IC 50 = 500 pM as measured in chromaffin granule membranes). Selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca 2+ -ATPases, Na + /K + -ATPases and plasma membrane H + -ATPases.

Biochem/physiol Actions

Bafilomycin A1 is a macrolide antibiotic. Bafilomycin A1 acts as a potent and selective inhibitor of vacuolar-type H+-ATPase.

storage

-20°C

References

1) Werner?et al.? (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity; J. Antibiot.,?37?110 2) Drose and Altendorf? (1997)?Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase;?J. Exp. Biol.,?200?1 3) Yamamoto?et al. (1998)?Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells;?Cell Struct. Func.,?23?33

BAFILOMYCIN A1 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAFILOMYCIN A1 Suppliers

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View Lastest Price from BAFILOMYCIN A1 manufacturers

Dideu Industries Group Limited

Product: BAFILOMYCIN A1 88899-55-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-16

Career Henan Chemical Co

Product: BAFILOMYCIN A1 88899-55-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-24

88899-55-2, BAFILOMYCIN A1Related Search:

Bufalin Thapsigargin 6-Gingerol OLIGOMYCIN A citreoviridin BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO- MYCES SPECIES,bafilomycin b1from streptomyces sp.,BAFILOMYCIN B1 bafilomycin D BAFILOMYCIN C1 BAFILOMYCIN A1 BAFILOMYCIN B2 BAFILOMYCIN B2 FROM STREPTOMYCES GRISEUS BAFILOMYCIN B1 MONOHYDRATE Bafilomycin D2' Bafilomycin E Bafilomycin D1 Bafilomycin C2 Bafilomycin A2 BAFILOMYCIN A1 (DRY ICE)

Bafilomycin A1 Bafilomycin A1 from Streptomyces griseus

Bafilomycin A1(Baf-A1)

Bafilomycin A1, 95%, from Streptomyces griseus

CS-1163

Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem

BAFILOMYCIN A1

BAFILOMYCIN A1, STREPTOMYCES GRISEUS

Bafilomycin A1 from Streptomycesgriseus, 10 ug

BAFILOMYCIN A1, 98+%

BAFILOMYCIN A1 95%

(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-((1S,2R,3S)-2-hydroxy-1-methyl-3-((2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5

BafilomycinA1fromStreptomycesgriseus

21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin

Bafilomycin A1,95%

(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one

(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-Methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-Methyl-6-(1-Methylethyl)-2H-pyran-2-yl]butyl]-3,15-diMethoxy-5,7,9,11-tetraMethyloxacyclohexadeca-3,5,11,13-tetraen-2-o

Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-, (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-

BafilomycinBafilomycin A1Bafilomycin A1, from Streptomyces griseus

BAFILOMYCIN A1 USP/EP/BP

(3Z,5Z,7R,8S,9S,11E,13E,15S,16R)-16-((2S,3R,4S)-4-((2R,4R,5S,6R)-2,4-Dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl)-3-hydroxypentan-2-yl)-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one

afilomycin A1

(3Z,5E,11E,13E)-16-[4-(2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl)-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one

Bafilomycin A1, (V)-ATPase inhibitor

88899-55-2

C35H58O9

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antibiotic

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Inhibits an EnzymeAntibiotics

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Peptide Synthesis/Antibiotics