ChemicalBook > CAS DataBase List > DBeQ

DBeQ

Product Name
DBeQ
CAS No.
177355-84-9
Chemical Name
DBeQ
Synonyms
JRF;DBeQ;JRF 12;CS-982;DBeQ (JRF 12);DBeQ USP/EP/BP;JRF 12; JRF12; JRF-12;N,N'-Dibenzylquinazoline-2,4-diamine;N,N'-Dibenzylquinazoline-2,4-diamine;N2,N4-Dibenzylquinazoline-2,4-diamine
CBNumber
CB02569682
Molecular Formula
C22H20N4
Formula Weight
340.42
MOL File
177355-84-9.mol
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DBeQ Property

Melting point:
149 °C
Boiling point:
573.1±52.0 °C(Predicted)
Density 
1.259±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: ≥20mg/mL
form 
powder
pka
7.78±0.30(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey
QAIMUUJJAJBPCL-UHFFFAOYSA-N
CAS DataBase Reference
177355-84-9
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26
WGK Germany 
3
HS Code 
2933.59.8000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0031
Product name
DBeQ
Purity
≥98% (HPLC)
Packaging
5mg
Price
$111
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0031
Product name
DBeQ
Purity
≥98% (HPLC)
Packaging
25mg
Price
$451
Updated
2024/03/01
TCI Chemical
Product number
D5476
Product name
DBeQ
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$103
Updated
2024/03/01
TCI Chemical
Product number
D5476
Product name
DBeQ
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$308
Updated
2024/03/01
Cayman Chemical
Product number
15318
Product name
DBeQ
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
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DBeQ Chemical Properties,Usage,Production

Description

DBeQ (177355-84-9) is a potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks ubiquitin-dependent protein clearance pathways. Cell permeable.

Uses

The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.[Cayman Chemical]

Uses

HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.

Biochem/physiol Actions

DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.

storage

Store at +4°C

References

1) Chou et al. (2011), Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways; Proc. Natl. Acad. Sci. USA, 108 4834

DBeQ Preparation Products And Raw materials

Raw materials

Preparation Products

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DBeQ Suppliers

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177355-84-9, DBeQRelated Search:

Pevonedistat BAFILOMYCIN A1 AZD6738 SGC707 MS023 2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide Enasidenib Epacadostat (INCB024360) indoleaMine-2,3-dioxygenase inhibitor INCB024360 LLY-507 4-BroMo-N-(4-broMophenyl)-3-[[(phenylMethyl)aMino]sulfonyl]benzaMide NMS 873 Ezetimibe Cabozantinib Fingolimod hydrochloride Veliparib Givinostat (ITF2357)

  • DBeQ
  • 2,4-QuinazolinediaMine, N2,N4-bis(phenylMethyl)-
  • 2,4-QuinazolinediaMine, N,N'-bis(phenylMethyl)-
  • JRF 12
  • N,N'-Dibenzylquinazoline-2,4-diamine
  • N2,N4-Dibenzylquinazoline-2,4-diamine
  • JRF
  • N,N'-Dibenzylquinazoline-2,4-diamine DBeQ
  • N2,N4-Dibenzylquinazoline-2,4-diamine DBeQ
  • N,N'-Dibenzyl-2,4-quinazolinediamine, 99%
  • N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
  • JRF 12; JRF12; JRF-12
  • CS-982
  • DBeQ (JRF 12)
  • DBeQ USP/EP/BP
  • N,N'-Dibenzylquinazoline-2,4-diamine
  • 177355-84-9
  • API
  • Inhibitors