DBeQ
- Product Name
- DBeQ
- CAS No.
- 177355-84-9
- Chemical Name
- DBeQ
- Synonyms
- JRF;DBeQ;JRF 12;CS-982;DBeQ (JRF 12);DBeQ USP/EP/BP;JRF 12; JRF12; JRF-12;N,N'-Dibenzylquinazoline-2,4-diamine;N,N'-Dibenzylquinazoline-2,4-diamine;N2,N4-Dibenzylquinazoline-2,4-diamine
- CBNumber
- CB02569682
- Molecular Formula
- C22H20N4
- Formula Weight
- 340.42
- MOL File
- 177355-84-9.mol
DBeQ Property
- Melting point:
- 149 °C
- Boiling point:
- 573.1±52.0 °C(Predicted)
- Density
- 1.259±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- pka
- 7.78±0.30(Predicted)
- color
- white to beige
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- InChIKey
- QAIMUUJJAJBPCL-UHFFFAOYSA-N
- CAS DataBase Reference
- 177355-84-9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0031
- Product name
- DBeQ
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- SML0031
- Product name
- DBeQ
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $451
- Updated
- 2024/03/01
- Product number
- D5476
- Product name
- DBeQ
- Purity
- >98.0%(HPLC)
- Packaging
- 25mg
- Price
- $103
- Updated
- 2024/03/01
- Product number
- D5476
- Product name
- DBeQ
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $308
- Updated
- 2024/03/01
- Product number
- 15318
- Product name
- DBeQ
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
DBeQ Chemical Properties,Usage,Production
Description
DBeQ (177355-84-9) is a potent, selective and reversible inhibitor of the AAA-ATPase p97 (ATPase associated with diverse cellular activities). Ki=3.2 μM. DBeQ blocks ubiquitin-dependent protein clearance pathways. Cell permeable.
Uses
The ATPase p97 is an ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. DBeQ is a selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM). It does not exhibit activity when tested against a panel 170 protein kinases at concentrations as high as 15 μM. At 10 μM it blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.[Cayman Chemical]
Uses
HeLa cells were treated with DBeQ and the effects on in vivo ubiquitination and protein dislocation were studied by live cell imaging.
Biochem/physiol Actions
DBeQ is a potent and specific inhibitor of ATPase p97, an integral component of the ubiquitin-fusion degradation (UFD) pathway. DBeQ inhibits the degradation of ubiquitinated proteins, the endoplasmic reticulum-associated degradation pathway, and autophagosome maturation. The compound also potently inhibits cellular proliferation and induces caspase 3/7 activity and apoptosis.
storage
Store at +4°C
References
1) Chou et al. (2011), Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways; Proc. Natl. Acad. Sci. USA, 108 4834