LDN-57444

ChemicalBook > CAS DataBase List > LDN-57444

Product Name: LDN-57444
CAS No.: 668467-91-2
Chemical Name: LDN-57444
Synonyms: CS-988;LDN-57444;UCH-L1 Inhibitor;LDN 57444, >=98%;LDN-57444/LDN57444;LDN-57444 USP/EP/BP;UCH-L1 INHIBITOR;LDN57444;UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem;3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one;(Z)-3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one
CBNumber: CB5804575
Molecular Formula: C17H11Cl3N2O3
Formula Weight: 397.64
MOL File: 668467-91-2.mol

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LDN-57444 Property

Boiling point:: 534.4±60.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble16mg/mL
form: solid
pka: -2.57±0.20(Predicted)
color: Yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L4170
Product name: LDN-57444
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: 662086
Product name: UCH-L1 Inhibitor
Packaging: 10mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 15396
Product name: LDN-57444
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 15396
Product name: LDN-57444
Purity: ≥95%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Sigma-Aldrich

Product number: L4170
Product name: LDN-57444
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $470
Updated: 2024/03/01

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LDN-57444 Chemical Properties,Usage,Production

Description

The ubiquitin C-terminal hydrolase L1 (UCH-L1) is a member of a family of de-ubiquitinating enzymes that can generate free ubiquitin from ubiquitin precursors via its ubiquitin ligase activity. By associating with free ubiquitin, it also prevents its degradation. Neuronal UCH-L1 has been linked to Parkinson’s disease, the development of tumors, and neuropathic pain. LDN-57444 is an inhibitor of UCH-L1 activity (IC₅₀ = 0.88, K_i = 0.4 μM) that demonstrates selectivity for UCH-L1 compared to UCH-L3 (IC₅₀ = 25 μM). Loss of UCH-L1 activity causes cell death through the apoptosis pathway due to an impaired ubiquitin-proteasome pathway. LDN-57444-induced reduction of free ubiquitin has been shown to create dramatic alterations in synaptic structure and function, increasing spine size while decreasing spine density in hippocampal neurons.

Uses

LDN 57444 is an inhibitor of UCH-L1, an enzyme expressed by certain lung tumor-derived cell lines, suggesting that this enzyme plays a role in tumor progression.

Biochem/physiol Actions

LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1

References

1) Liu et al. (2003), Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line; Chem. Biol., 10 837 2) Tan et al. (2008), Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor; Mol. Cell. Biochem., 318 109 3) Cartier et al. (2009), Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1; J. Neurosci., 29 7857

LDN-57444 Preparation Products And Raw materials

Raw materials

Preparation Products

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LDN-57444 Suppliers

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668467-91-2, LDN-57444Related Search:

CONCANAMYCIN A 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione SGC-GAK-1 SALUBRINAL GSK1904529A PR-619 TCID Pemetrexed Disodium Clofarabine SKI II

LDN-57444

5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione3-(O-acetyloxime)

LDN-57444/LDN57444

1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime)

5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime) LDN 57444

3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione

UCH-L1 Inhibitor

(Z)-3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one

LDN 57444, >=98%

UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem

CS-988

UCH-L1 INHIBITOR;LDN57444

LDN-57444 USP/EP/BP

3-(Acetoxyimino)-5-chloro-1-(2,5-dichlorobenzyl)indolin-2-one

668467-91-2

Inhibitors