5-(TETRADECYLOXY)-2-FUROIC ACID

Product Name: 5-(TETRADECYLOXY)-2-FUROIC ACID
CAS No.: 54857-86-2
Chemical Name: 5-(TETRADECYLOXY)-2-FUROIC ACID
Synonyms: TOFA;mdl14514;RMI-14514;TOFA (RMI14514;RMI14514; MDL14514;TOFA (RMI14514:MDL14514);5-tetradecyloxy-2-furonicacid;5-(TETRADECYLOXY)-2-FUROIC ACID;5-(TETRADECYLOXY)-2-FUROIC TOFA;TOFA - CAS 54857-86-2 - Calbiochem
CBNumber: CB4759746
Molecular Formula: C19H32O4
Formula Weight: 324.45
MOL File: 54857-86-2.mol

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5-(TETRADECYLOXY)-2-FUROIC ACID Property

Melting point:: 112-115 °C
Boiling point:: 441.7±25.0 °C(Predicted)
Density: 1.003±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: 2.5 mg/mL
form: solid
pka: 3.55±0.10(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

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Safety

WGK Germany: 2
RTECS: LU0288000
HS Code: 29321900

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T6575
Product name: TOFA
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $233
Updated: 2024/03/01

Sigma-Aldrich

Product number: 613450
Product name: TOFA
Packaging: 5mg
Price: $390
Updated: 2024/03/01

Alfa Aesar

Product number: J67337
Product name: TOFA
Purity: 99%
Packaging: 10mg
Price: $155
Updated: 2023/06/20

Cayman Chemical

Product number: 10005263
Product name: TOFA
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 10005263
Product name: TOFA
Purity: ≥98%
Packaging: 10mg
Price: $62
Updated: 2024/03/01

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5-(TETRADECYLOXY)-2-FUROIC ACID Chemical Properties,Usage,Production

Description

TOFA (54857-86-2) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1).1 Induces apoptosis in a variety of tumor cell lines.2,3 Stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells.4 TOFA impairs glucose-stimulated insulin secretion after chronic treatment.5

Uses

TOFA has been used as a lipid biosynthesis inhibitor in mesenchymal stromal cells (MSCs), human pluripotent stem cells., an acetyl-CoA carboxylase 1 inhibitor in murine adipocyte cell lines., a lipolysis inhibitor in cancer stem cells (CSCs).

Definition

ChEBI: A member of the class of furans that is 2-furoic acid in which the hydrogen at position 5 is replaced by a tetradecyloxy group.

Biochem/physiol Actions

5-(Tetradecyloxy)-2-furoic acid (TOFA) elicits hypolipidemic?functionality by favoring fatty acid breakdown and at the same time preventing biosynthesis. It induces apoptosis in pancreatic cancer cells and favors tumor suppression.

References

References/Citations: 1) Halvorson?et al. (1984),?Inhibition of fatty acid synthesis in isolated adipocytes by 5-tetradecyloxy)-2-furoic acid; Lipids,?19?851 2) Guseva?et al. (2011),?TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status; Cancer Biol. Ther.,?12?80 3) Zhou?et al. (2003),?Fatty acid synthesis inhibition triggers apoptosis during S phase in human cancer cells; Cancer Res.,?63?7330 4) Schmidt?et al. (1999),?Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family; Mol. Cell. Endocrinol.,?155?51 5) Ronnebaum?et al. (2008),?Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism; J. Biol. Chem.,?283?14248

5-(TETRADECYLOXY)-2-FUROIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-(TETRADECYLOXY)-2-FUROIC ACID manufacturers

Career Henan Chemical Co

Product: 5-(TETRADECYLOXY)-2-FUROIC ACID 54857-86-2
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

54857-86-2, 5-(TETRADECYLOXY)-2-FUROIC ACIDRelated Search:

Imatinib mesylate CL 82198 HYDROCHLORIDE (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT 17-AAG N-OCTADECYLMETHOXYDICHLOROSILANE N/A Ethoxylated ammonium alkyl sulfate 5-ETHOXY-FURAN-2-CARBOXYLIC ACID 2-METHOXYFURAN 2-Furancarboxylicacid,5-methoxy-(9CI) 5-(TETRADECYLOXY)-2-FUROIC ACID

TOFA

5-(tetradecyloxy)-2-furancarboxylicaci

5-tetradecyloxy-2-furonicacid

mdl14514

RMI-14514

TOFA (5-(Tetradecyloxy)-2-furoic acid)

5-(TETRADECYLOXY)-2-FURANCARBOXYLIC ACID

5-(TETRADECYLOXY)-2-FUROIC ACID

2-Furancarboxylic acid,5-(tetradecyloxy)-

TOFA (RMI14514

TOFA (RMI14514:MDL14514)

5-(TETRADECYLOXY)-2-FUROIC TOFA

TOFA - CAS 54857-86-2 - Calbiochem

RMI14514; MDL14514

inhibit,RMI 14514,Acetyl-CoA Carboxylase,ACC, Acetyl Coenzyme A Carboxylase,RMI-14514,TOFA,MDL 14514,MDL-14514,Inhibitor

54857-86-2

A to C

Biochemicals and Reagents

BioChemical

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

Enzymes, Inhibitors, and Substrates

Acetyl CoA-Carboxylase