5-(TETRADECYLOXY)-2-FUROIC ACID
- Product Name
- 5-(TETRADECYLOXY)-2-FUROIC ACID
- CAS No.
- 54857-86-2
- Chemical Name
- 5-(TETRADECYLOXY)-2-FUROIC ACID
- Synonyms
- TOFA;mdl14514;RMI-14514;TOFA (RMI14514;RMI14514; MDL14514;TOFA (RMI14514:MDL14514);5-tetradecyloxy-2-furonicacid;5-(TETRADECYLOXY)-2-FUROIC ACID;5-(TETRADECYLOXY)-2-FUROIC TOFA;TOFA - CAS 54857-86-2 - Calbiochem
- CBNumber
- CB4759746
- Molecular Formula
- C19H32O4
- Formula Weight
- 324.45
- MOL File
- 54857-86-2.mol
5-(TETRADECYLOXY)-2-FUROIC ACID Property
- Melting point:
- 112-115 °C
- Boiling point:
- 441.7±25.0 °C(Predicted)
- Density
- 1.003±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: 2.5 mg/mL
- form
- solid
- pka
- 3.55±0.10(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety
- WGK Germany
- 2
- RTECS
- LU0288000
- HS Code
- 29321900
N-Bromosuccinimide Price
- Product number
- T6575
- Product name
- TOFA
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $233
- Updated
- 2024/03/01
- Product number
- 613450
- Product name
- TOFA
- Packaging
- 5mg
- Price
- $390
- Updated
- 2024/03/01
- Product number
- J67337
- Product name
- TOFA
- Purity
- 99%
- Packaging
- 10mg
- Price
- $155
- Updated
- 2023/06/20
- Product number
- 10005263
- Product name
- TOFA
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 10005263
- Product name
- TOFA
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $62
- Updated
- 2024/03/01
5-(TETRADECYLOXY)-2-FUROIC ACID Chemical Properties,Usage,Production
Description
TOFA (54857-86-2) interferes with fatty acid synthase via inhibition of acetyl Co-A carboxylase (ACC1).1 Induces apoptosis in a variety of tumor cell lines.2,3 Stimulates neurite outgrowth and neuronal differentiation in rat pheochromocytoma cells.4 TOFA impairs glucose-stimulated insulin secretion after chronic treatment.5
Uses
TOFA has been used as a lipid biosynthesis inhibitor in mesenchymal stromal cells (MSCs), human pluripotent stem cells., an acetyl-CoA carboxylase 1 inhibitor in murine adipocyte cell lines., a lipolysis inhibitor in cancer stem cells (CSCs).
Definition
ChEBI: A member of the class of furans that is 2-furoic acid in which the hydrogen at position 5 is replaced by a tetradecyloxy group.
Biochem/physiol Actions
5-(Tetradecyloxy)-2-furoic acid (TOFA) elicits hypolipidemic?functionality by favoring fatty acid breakdown and at the same time preventing biosynthesis. It induces apoptosis in pancreatic cancer cells and favors tumor suppression.
References
References/Citations: 1) Halvorson?et al. (1984),?Inhibition of fatty acid synthesis in isolated adipocytes by 5-tetradecyloxy)-2-furoic acid; Lipids,?19?851 2) Guseva?et al. (2011),?TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status; Cancer Biol. Ther.,?12?80 3) Zhou?et al. (2003),?Fatty acid synthesis inhibition triggers apoptosis during S phase in human cancer cells; Cancer Res.,?63?7330 4) Schmidt?et al. (1999),?Transcription control and neuronal differentiation by agents that activate the LXR nuclear receptor family; Mol. Cell. Endocrinol.,?155?51 5) Ronnebaum?et al. (2008),?Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism; J. Biol. Chem.,?283?14248
5-(TETRADECYLOXY)-2-FUROIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-(TETRADECYLOXY)-2-FUROIC ACID manufacturers
- Product
- 5-(TETRADECYLOXY)-2-FUROIC ACID 54857-86-2
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02