ChemicalBook > CAS DataBase List > P7C3

P7C3

Product Name: P7C3
CAS No.: 301353-96-8
Chemical Name: P7C3
Synonyms: P7C3;CS-1463;P7C3, >97%;P7C3, >=98%;P7C3; 301353-96-8;P7C3, 10 mM in DMSO;1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol;P7C3, pro-neurogenic and neuroprotective compound;6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol;3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol
CBNumber: CB62535687
Molecular Formula: C21H18Br2N2O
Formula Weight: 474.19
MOL File: 301353-96-8.mol

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P7C3 Property

Boiling point:: 656.4±55.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble34mg/mL
form: powder
pka: 13.91±0.20(Predicted)
color: white to off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months

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Safety

Hazard Codes: T
Risk Statements: 25-41
Safety Statements: 26-39-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D8446
Product name: P7C3
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $147
Updated: 2025/07/31

Sigma-Aldrich

Product number: D8446
Product name: P7C3
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $578
Updated: 2025/07/31

Cayman Chemical

Product number: 16682
Product name: P7C3
Purity: ≥98%
Packaging: 5mg
Price: $105
Updated: 2024/03/01

Cayman Chemical

Product number: 16682
Product name: P7C3
Purity: ≥98%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 16682
Product name: P7C3
Purity: ≥98%
Packaging: 25mg
Price: $410
Updated: 2024/03/01

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P7C3 Chemical Properties,Usage,Production

Description

P7C3 is an orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus. At doses of 5 mg/kg and above, it has been shown to promote the survival of neurons in various rodent models of neurodegeneration or nerve injury. While the precise mechanism of action through which these effects are exerted remains uncertain, P7C3 recently has been shown to bind nicotinamide phosphoribosyltransferase, the rate-limiting enzyme involved in the conversion of nicotinamide into NAD.

Uses

P7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus. P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury.

Biochem/physiol Actions

P7C3 is neurogenic and protects new neurons against apoptosis. These activities may be related to its capacity to protect mitochondrial integrity.Degeneration of the hippocampus is an early manifestation of Alzheimer′s disease. P7C3 promotes neurogenesis in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals, making it an important lead compound in development of new Alzheimer′s treatments.

in vivo

P7C3 (20 mg/kg/d; i.p.; twice daily; for 21 days ) inhibits microglial activation and microglia-mediated dopaminergic (DA) neuronal loss in vivo^[3].

Animal Model:	6-8 weeks male C57BL/6 mice (25-30 g)^[3]
Dosage:	20 mg/kg/d
Administration:	Intraperitoneal injection, twice daily, for 21 days
Result:	Strikingly decreased the expressions of (a microglia marker) and GFAP (an astrocyte marker) LPS-induced in the substantia nigra pars compacta (SNpc).

storage

Store at RT

References

[1] ANDREW A PIEPER. Discovery of a proneurogenic, neuroprotective chemical.[J]. Cell, 2010: 39-51. DOI:10.1016/j.cell.2010.06.018
[2] RACHEL TESLA. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.[J]. ACS Catalysis , 2012: 17016-17021. DOI:10.1073/pnas.1213960109
[3] HÉCTOR DE JESÚS-CORTÉS. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease.[J]. ACS Catalysis , 2012: 17010-17015. DOI:10.1073/pnas.1213956109
[4] SARAH E. LATCHNEY . Erratum to “Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome” [Neurosci. Lett. 591 (2015) 86–92][J]. Neuroscience Letters, 2015, 597: Page 25. DOI:10.1016/j.neulet.2015.04.024
[5] GELIN WANG. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.[J]. Cell, 2014: 1324-1334. DOI:10.1016/j.cell.2014.07.040

P7C3 Preparation Products And Raw materials

Raw materials

Preparation Products

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P7C3 Suppliers

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301353-96-8, P7C3Related Search:

C 646 LDN-57444 5-(TETRADECYLOXY)-2-FUROIC ACID

1-(3,6-DIBROMO-9H-CARBAZOL-9-YL)-3-(PHENYLAMINO)PROPAN-2-OL

3,6-Dibromo-a-[(phenylamino)methyl]-9H-carbazole-9-ethanol

P7C3, >=98%

6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol

P7C3; 301353-96-8

CS-1463

P7C3, >97%

3,6-Dibromo-α-[(phenylamino)methyl]-9H-carbazole-9-ethanol

9H-Carbazole-9-ethanol, 3,6-dibromo-α-[(phenylamino)methyl]-

P7C3,inhibit,injury,Inhibitor,nerve,neurodegeneration,neuroprotective,Parkinson's,neurodegenerative diseases,disease,cell,P-7C3

1-anilino-3-(3,6-dibromocarbazol-9-yl)propan-2-ol

P7C3, pro-neurogenic and neuroprotective compound

P7C3, 10 mM in DMSO

P7C3

301353-96-8

Inhibitors

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