DIBENZAZEPINE
- Product Name
- DIBENZAZEPINE
- CAS No.
- 209984-56-5
- Chemical Name
- DIBENZAZEPINE
- Synonyms
- GSI-XX;CS-366;YO01027;DIBENZAZEPINE;Deshydroxy LY-411575;6-Chloro-α-Tetralone;YO-01027 (Dibenzazepine);γ-Secretase Inhibitor XX;Dibenzazepine (YO-01027);γ-Secretase Inhibitor XX
- CBNumber
- CB11234300
- Molecular Formula
- C26H23F2N3O3
- Formula Weight
- 463.48
- MOL File
- 209984-56-5.mol
DIBENZAZEPINE Property
- Melting point:
- 257-259?C
- Boiling point:
- 801.3±65.0 °C(Predicted)
- Density
- 1.35
- storage temp.
- -20°C
- solubility
- DMSO: soluble15mg/mL, clear
- pka
- 12.76±0.20(Predicted)
- form
- White solid
- color
- white to beige
- InChIKey
- QSHGISMANBKLQL-OWJWWREXSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 565789
- Product name
- γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem
- Purity
- This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model.
- Packaging
- 500μg
- Price
- $417
- Updated
- 2024/03/01
- Product number
- 565789
- Product name
- γ-Secretase Inhibitor XX
- Packaging
- 1mg
- Price
- $532
- Updated
- 2024/03/01
- Product number
- J64904
- Product name
- gamma-Secretase Inhibitor XX
- Packaging
- 3mg
- Price
- $761
- Updated
- 2023/06/20
- Product number
- 14627
- Product name
- DBZ
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 14627
- Product name
- DBZ
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $63
- Updated
- 2024/03/01
DIBENZAZEPINE Chemical Properties,Usage,Production
Description
γ-
Chemical Properties
White Solid
Uses
γ-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Aβ), a 39- to 42-amino acid peptide which forms the amyloid plaques that are characteristic of Alzheimer’s disease. DBZ is a dipeptidic inhibitor of γ-secretase that potently blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC50 = 1.7 nM). Within 4 hours after a single 100 μM/kg dose, DBZ demonstrates anti-Alzheimer activity in an APP transgenic mouse model characterized by high levels of Aβ40 by reducing Aβ40 levels by 71%.
Uses
DIBENZAZEPINE is a dipeptidic-secretase inhibitor and a antiAlzheimer agent.
Uses
A dipeptidic γ-secretase inhibitor. AntiAlzheimer agent.
General Description
A cell-permeable, potent γ-secretase inhibitor that significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 μmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50 = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10 μmol/kg, i.p).
Biochem/physiol Actions
Cell permeable: yes
target
APPL
storage
-20°C
DIBENZAZEPINE Preparation Products And Raw materials
Raw materials
Preparation Products
DIBENZAZEPINE Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94657
- Advantage
- 76
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 0330-2528181
- Fax
- 0330-2528171
- sales@vdmbio.com
- Country
- United States
- ProdList
- 510
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- +86 (531) 88811783
- Fax
- +86 (531) 55696010 QQ 1762738062
- sales@trio-pharmatech.com (International market)
- Country
- China
- ProdList
- 1856
- Advantage
- 62
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9658
- Advantage
- 60
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4727
- Advantage
- 58
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 028-81458053
- Fax
- 028-81458053
- novibiotech@163.com sales@novi-biotech.com
- Country
- China
- ProdList
- 226
- Advantage
- 55
View Lastest Price from DIBENZAZEPINE manufacturers
- Product
- DIBENZAZEPINE 209984-56-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 200kg
- Release date
- 2020-03-05