FLI-06
Background- Product Name
- FLI-06
- CAS No.
- 313967-18-9
- Chemical Name
- FLI-06
- Synonyms
- I-06;FLI-06;CS-1434;FLI-06 |FLI06;FLI-06, 10 mM in DMSO;FLI-06, Notch signaling inhibitor;inhibit,Inhibitor,Notch,FLI-06,FLI06;FLI-06, 98%, a notch signaling and the early secretory pathway inhibitor;Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester
- CBNumber
- CB82682028
- Molecular Formula
- C25H30N2O5
- Formula Weight
- 438.52
- MOL File
- 313967-18-9.mol
FLI-06 Property
- Melting point:
- 199-202oC
- Boiling point:
- 597.5±50.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- 0.78±0.70(Predicted)
- form
- powder
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
- InChI
- 1S/C25H30N2O5/c1-15-21(24(29)32-18-7-5-4-6-8-18)22(16-9-11-17(12-10-16)27(30)31)23-19(26-15)13-25(2,3)14-20(23)28/h9-12,18,22,26H,4-8,13-14H2,1-3H3
- InChIKey
- SWWVFYHSSOWZMF-UHFFFAOYSA-N
- SMILES
- [N+](=O)([O-])c1ccc(cc1)C2C3=C(NC(=C2C(=O)OC4CCCCC4)C)CC(CC3=O)(C)C
Safety
- RIDADR
- 3077
- WGK Germany
- 3
- HS Code
- 29339900
- Storage Class
- 11 - Combustible Solids
N-Bromosuccinimide Price
- Product number
- SML0975
- Product name
- FLI-06
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $111
- Updated
- 2026/03/19
- Product number
- SML0975
- Product name
- FLI-06
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $446
- Updated
- 2026/03/19
- Product number
- 21272
- Product name
- FLI-06
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 21272
- Product name
- FLI-06
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $146
- Updated
- 2024/03/01
- Product number
- 21272
- Product name
- FLI-06
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $317
- Updated
- 2024/03/01
FLI-06 Chemical Properties,Usage,Production
Description
FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early stage in secretory traffic.1
Uses
FLI-06 is a novel inhibitor of Notch signalling and the early secretory pathway.
Background
The dihydropyridine FLI-06 is a Notch pathway inhibitor with an EC50 of 2.5 mM. Signaling through Notch transmembrane receptor proteins plays an important role in cell-fate decisions; aberrant Notch activity can result in cancer and other developmental disorders. FLI-06 acts at an early stage in the secretory pathway, disrupting the Golgi and inhibiting general secretion before exit from the endoplasmic reticulum. Studies show that FLI-06 suppresses both the mRNA and protein expression of Notch receptor and Notch targeted genes. FLI-06 treatment of tongue cancer cells inhibits Notch signaling activation, decreasing cell proliferation, blocking cell cycle arrest, and inducing apoptosis. FLI-06 inhibited tumor growth and increased cell apoptosis in a xenograft mouse model, suggesting that FLI-06 is a potential chemotherapeutic agent for the clinical treatment of tongue tumors. Additional studies showed that FLI-06 inactivated Notch signaling and suppressed malignant functions in lung adenocarcinoma and esophageal squamous cell carcinoma.
References
[1] ANDREAS KRÄMER. Small molecules intercept Notch signaling and the early secretory pathway[J]. Nature chemical biology, 2013, 9 11: 731-738. DOI:10.1038/nchembio.1356
FLI-06 Preparation Products And Raw materials
Raw materials
Preparation Products
FLI-06 Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
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- China
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- 55
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- 0411-62910999 13889544652
- sales@meilune.com
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- China
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- 58
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- 021-61312847 13636370518
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- 021-55068248
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- China
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- 5000
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- 60
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- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
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- 7552
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- 61
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2782
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- 58
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 40000
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- 60
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
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- 2990
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- 60
- Tel
- 0576-88813233 88205808
- Fax
- 0576-88229589
- sales@taizhoukerui.com
- Country
- China
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- 137
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- 57
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9541
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- 58
View Lastest Price from FLI-06 manufacturers
- Product
- 3-?Quinolinecarboxylic acid, 1,?4,?5,?6,?7,?8-?hexahydro-?2,?7,?7-?trimethyl-?4-?(4-?nitrophenyl)?-?5-?oxo-?, cyclohexyl ester 313967-18-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23