FLI-06

ChemicalBook > CAS DataBase List > FLI-06

Product Name: FLI-06
CAS No.: 313967-18-9
Chemical Name: FLI-06
Synonyms: I-06;FLI-06;CS-1434;FLI-06 |FLI06;inhibit,Inhibitor,Notch,FLI-06,FLI06;FLI-06, 98%, a notch signaling and the early secretory pathway inhibitor;Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester;3-QUINOLINECARBOXYLIC ACID, 1,4,5,6,7,8-HEXAHYDRO-2,7,7-TRIMETHYL-4-(4-NITROPHENYL)-5-OXO-, CYCLOHEXYL ESTER;1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester FLI-06
CBNumber: CB82682028
Molecular Formula: C25H30N2O5
Formula Weight: 438.52
MOL File: 313967-18-9.mol

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FLI-06 Property

Melting point:: 199-202oC
Boiling point:: 597.5±50.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
pka: 0.78±0.70(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.

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Safety

RIDADR: 3077
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0975
Product name: FLI-06
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0975
Product name: FLI-06
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $190.4
Updated: 2024/03/01

Cayman Chemical

Product number: 21272
Product name: FLI-06
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 21272
Product name: FLI-06
Purity: ≥98%
Packaging: 10mg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 21272
Product name: FLI-06
Purity: ≥98%
Packaging: 25mg
Price: $317
Updated: 2024/03/01

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FLI-06 Chemical Properties,Usage,Production

Description

FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early stage in secretory traffic.1

Uses

FLI-06 is a novel inhibitor of Notch signalling and the early secretory pathway.

References

1) Kramer?et al., (2013),?Small molecules intercept Notch signaling and the early secretory pathway; Nat. Chem. Biol.?9 731

FLI-06 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from FLI-06 manufacturers

Career Henan Chemical Co

Product: 3-?Quinolinecarboxylic acid, 1,?4,?5,?6,?7,?8-?hexahydro-?2,?7,?7-?trimethyl-?4-?(4-?nitrophenyl)?-?5-?oxo-?, cyclohexyl ester 313967-18-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-23

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FLI-06

1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester

1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester FLI-06

3-QUINOLINECARBOXYLIC ACID, 1,4,5,6,7,8-HEXAHYDRO-2,7,7-TRIMETHYL-4-(4-NITROPHENYL)-5-OXO-, CYCLOHEXYL ESTER

FLI-06, 98%, a notch signaling and the early secretory pathway inhibitor

FLI-06 |FLI06

Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate

CS-1434

I-06

inhibit,Inhibitor,Notch,FLI-06,FLI06

313967-18-9

Inhibitors