2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol

Product Name: 2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol
CAS No.: 304684-77-3
Chemical Name: 2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol
Synonyms: Exo2;Exo2 >=98% (HPLC);2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol;Benzaldehyde, 4-hydroxy-3-methoxy-, 2-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)hydrazone
CBNumber: CB82750352
Molecular Formula: C18H18N4O2S
Formula Weight: 354.43
MOL File: 304684-77-3.mol

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2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol Property

Boiling point:: 591.0±50.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
form: powder
pka: 8.79±0.35(Predicted)
color: yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E7159
Product name: Exo2
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $89.68
Updated: 2025/07/31

Sigma-Aldrich

Product number: E7159
Product name: Exo2
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $264
Updated: 2025/07/31

Biorbyt Ltd

Product number: orb545927
Product name: Exo2
Purity: >98%
Packaging: 25mg
Price: $469.2
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PRB0000014
Product name: EXO2
Purity: 95.00%
Packaging: 5MG
Price: $649.35
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PRB0000014
Product name: EXO2
Purity: 95.00%
Packaging: 25MG
Price: $842.26
Updated: 2021/12/16

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2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol Chemical Properties,Usage,Production

Description

Exo2 (304684-77-3) disrupts the Golgi apparatus and stimulates Golgi-ER fusion in mammalian cells.1 May be used to completely ablate the Golgi apparatus.1 Like brefeldin A (BFA), it inhibits anterograde transport and disrupts morphology of the trans-Golgi network (TGN) but unlike BFA, it does not induce tubulation and merging of the TGN and endosomal compartments.2? It perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network, in contrast to cholera toxin.1,2 Accelerates degradation of perilipin-2 proteins.3

Uses

Exo2 is a secretion inhibitor. Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Exo2 blocks secretory cargo exit from the ER (endoplasmic reticulum) and disrupts the Golgi apparatus, but does not affect the morphology of the TGN (trans-Golgi network) Exo2 can stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells[1][2].

Definition

ChEBI: Exo2 is a member of phenols and a member of methoxybenzenes.

References

[1] YAN FENG. Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells.[J]. EMBO Reports, 2004, 5 6: 596-601. DOI:10.1038/sj.embor.7400152
[2] ROBERT A SPOONER. The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network.[J]. Biochemical Journal, 2008: 471-484. DOI:10.1042/bj20080149
[3] ALAIN PAULOIN. The perilipin-2 (adipophilin) coat of cytosolic lipid droplets is regulated by an Arf1-dependent mechanism in HC11 mouse mammary epithelial cells[J]. Cell Biology International, 2015, 40 2: 143-155. DOI:10.1002/cbin.10547

2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol Suppliers

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304684-77-3, 2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenolRelated Search:

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2-Methoxy-4-[(5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-yl)-hydrazonomethyl]-phenol

Exo2

Exo2 >=98% (HPLC)

Benzaldehyde, 4-hydroxy-3-methoxy-, 2-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)hydrazone

304684-77-3