Selinexor

Product Name: Selinexor
CAS No.: 1393477-72-9
Chemical Name: Selinexor
Synonyms: Selinexor;Xpovio;KPT-330;CS-1056;Aloradine;Selinexorb;KPT330; KPT 330;KPT330,Selinexor;KPT-330 USP/EP/BP;Selinexor (KPT-330)
CBNumber: CB12681123
Molecular Formula: C17H11F6N7O
Formula Weight: 443.31
MOL File: 1393477-72-9.mol

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Selinexor Property

Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to at least 25 mg/ml). or in Ethanol (up to at least 25 mg/ml)
pka: 9.74±0.43(Predicted)
form: solid
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI: InChI=1S/C17H11F6N7O/c18-16(19,20)11-5-10(6-12(7-11)17(21,22)23)15-26-9-30(29-15)4-1-14(31)28-27-13-8-24-2-3-25-13/h1-9H,(H,25,27)(H,28,31)/b4-1-
InChIKey: DEVSOMFAQLZNKR-RJRFIUFISA-N
SMILES: C(NNC1=NC=CN=C1)(=O)/C=C\N1C=NC(C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=N1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18127
Product name: KPT-330
Purity: ≥98%
Packaging: 1mg
Price: $29
Updated: 2021/12/16

Cayman Chemical

Product number: 18127
Product name: KPT-330
Purity: ≥98%
Packaging: 5mg
Price: $94
Updated: 2021/12/16

Cayman Chemical

Product number: 18127
Product name: KPT-330
Purity: ≥98%
Packaging: 10mg
Price: $160
Updated: 2021/12/16

Cayman Chemical

Product number: 18127
Product name: KPT-330
Purity: ≥98%
Packaging: 50mg
Price: $508
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180928
Product name: KPT-330(Selinexor)
Purity: >98%
Packaging: 100mg
Price: $765
Updated: 2021/12/16

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Selinexor Chemical Properties,Usage,Production

Description

Selinexor (1393477-72-9) is a potent inhibitor of the nuclear export receptor, chromosome region maintenance 1 (CRM1; Exportin-1 (XPO1)). It exhibited potent growth suppression in various T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50’s = 34-203 nM)1?and pancreatic cancer cells (IC50?~ 150 nM)2. Selinexor is being investigated as a possible chemotherapeutic in treating multiple types of cancer.3-8?Currently in clinical trials.

Uses

KPT 330 is a chromosome maintenance protein 1 (CRM1) inhibitor. KPT 330 suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.

Synthesis

Synthesis route of Selinexor

in vivo

Selinexor (KPT-330) dramatically suppresses the growth of T-ALL cells (MOLT-4) and AML cells (MV4–11) in vivo, with little toxicity to normal haematopoietic cells^[1]. In SCID mice with diffuse human MM bone lesions, KPT-330 inhibits MM-induced bone lysis and prolongs survival. Moreover, KPT-330 directly impairs osteoclastogenesis and bone resorption by blocking RANKL-induced NF-κB and NFATc1, with minimal impact on osteoblasts and BMSCs^[2].

storage

Store at -20°C

References

[1] JULIA ETCHIN. KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia[J]. British Journal of Haematology, 2013, 161 1: 117-127. DOI:10.1111/bjh.12231
[2] ASFAR S. AZMI . Selective Inhibitors of Nuclear Export Block Pancreatic Cancer Cell Proliferation and Reduce Tumor Growth in Mice[J]. Gastroenterology, 2013, 144 2: Pages 447-456. DOI:10.1053/j.gastro.2012.10.036
[3] JOHN A DESISTO. Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma.[J]. Molecular Cancer Therapeutics, 2020, 19 1: 540-551. DOI:10.1158/1535-7163.mct-18-1319
[4] AMRO ABOUKAMEEL. Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression.[J]. Oncotarget, 2018, 9 82: 35327-35342. DOI:10.18632/oncotarget.26239
[5] HAN BIT BAEK. XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies.[J]. Oncotarget, 2018: 34567-34581. DOI:10.18632/oncotarget.26179
[6] AMY WAHBA. The XPO1 Inhibitor Selinexor Inhibits Translation and Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and In Vivo.[J]. Molecular Cancer Therapeutics, 2018, 17 8: 1717-1726. DOI:10.1158/1535-7163.mct-17-1303
[7] NATALIA PAEZ ARANGO. Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer.[J]. Breast Cancer Research : BCR, 2017: 93. DOI:10.1186/s13058-017-0878-6
[8] FABIO CONFORTI. Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors.[J]. ACS Chemical Health & Safety, 2017: 5614-5627. DOI:10.1158/0008-5472.can-17-1323

Selinexor Preparation Products And Raw materials

Raw materials

Preparation Products

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Selinexor Suppliers

China 167 India 4 United States 14 Global 185

Shanghai Zhengyi Pharmaceutical Co., Ltd

Tel: 17740884366
Email: derek1229@163.com
Country: China
ProdList: 61
Advantage: 58

WuHu Linze pharmaceutical Co.,Ltd.

Tel: 18356571950
Fax: -
Email: 2030235803@qq.com
Country: China
ProdList: 94
Advantage: 58

Shanghai Mixiu Chemical Co., Ltd.

Tel: 18101936766
Fax: 021-58583907
Email: eileen@shmychem.com
Country: China
ProdList: 350
Advantage: 55

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Enantiotech Corporation Ltd

Tel: 760-85282375 13212762451
Email: marketing@enantiotech.net
Country: China
ProdList: 157
Advantage: 55

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

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View Lastest Price from Selinexor manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Selinexor Kpt-330 1393477-72-9
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-12-30

Wuhan Nutra Biotechnology Co.,Ltd

Product: Selinexor;KPT-330 1393477-72-9
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%+
Supply Ability: 100kgs
Release date: 2021-05-21

Hangzhou ICH Biofarm Co., Ltd

Product: Selinexor 1393477-72-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200
Release date: 2023-07-17

1393477-72-9, SelinexorRelated Search:

PD 173074 KPT-330, (E)-RN Verdinexor (KPT-335) Bortezomib (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3- MK-2206 2HCl OTX015 KPT-185 Ruxolitinib CONCANAMYCIN A Prostaglandin E2 SGC-GAK-1 2-BROMOHEXADECANOIC ACID 3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazole (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid 2-Propenoic acid, 3-iodo-, 1-methylethyl ester, (2Z)- (Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

KPT-330

(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide

Selinexor

Selinexor (KPT-330)

(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide

2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2Z)-

Aloradine

KPT330,Selinexor

(KPT330)(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide

SELINEXOR;KPT330;KPT 330

KPT-330,Selinexor, >98%

KPT330; KPT 330

CS-1056

(Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide

(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide(Selinexor)

Selinexor free base

KPT-330 USP/EP/BP

Selinexor (KPT 330),Selinexor (KPT330)

Xpovio

Selinexorb

Avatrombopag Impurity 32 Hydrochloride

KPT330 Selinexor（1393477-72-9）

1393477-72-9

C17H11F6N7O

Inhibitors

API