KPT-330

ChemicalBook > CAS DataBase List > KPT-330

Product Name: KPT-330
CAS No.: 1393477-72-9
Chemical Name: KPT-330
Synonyms: Selinexor;Xpovio;KPT-330;CS-1056;Aloradine;Selinexorb;KPT330; KPT 330;KPT330,Selinexor;KPT-330 USP/EP/BP;Selinexor (KPT-330)
CBNumber: CB12681123
Molecular Formula: C17H11F6N7O
Formula Weight: 443.31
MOL File: 1393477-72-9.mol

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KPT-330 Property

Density: 1.55±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to at least 25 mg/ml). or in Ethanol (up to at least 25 mg/ml)
form: solid
pka: 9.74±0.43(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18127
Product name: KPT-330
Purity: ≥98%
Packaging: 1mg
Price: $29
Updated: 2021/12/16

Cayman Chemical

Product number: 18127
Product name: KPT-330
Purity: ≥98%
Packaging: 5mg
Price: $94
Updated: 2021/12/16

Cayman Chemical

Product number: 18127
Product name: KPT-330
Purity: ≥98%
Packaging: 10mg
Price: $160
Updated: 2021/12/16

Cayman Chemical

Product number: 18127
Product name: KPT-330
Purity: ≥98%
Packaging: 50mg
Price: $508
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb180928
Product name: KPT-330(Selinexor)
Purity: >98%
Packaging: 100mg
Price: $765
Updated: 2021/12/16

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KPT-330 Chemical Properties,Usage,Production

Description

Selinexor (1393477-72-9) is a potent inhibitor of the nuclear export receptor, chromosome region maintenance 1 (CRM1; Exportin-1 (XPO1)). It exhibited potent growth suppression in various T-cell acute lymphoblastic leukemia (T-ALL) cells (IC50’s = 34-203 nM)1?and pancreatic cancer cells (IC50?~ 150 nM)2. Selinexor is being investigated as a possible chemotherapeutic in treating multiple types of cancer.3-8?Currently in clinical trials.

Uses

KPT 330 is a chromosome maintenance protein 1 (CRM1) inhibitor. KPT 330 suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells.

storage

Store at -20°C

References

1) Etchin?et al.?(2013),?KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-ALL and AML; Br. J. Haematol.?161?117 2) Azmi?et al. (2013),?Selective Inhibitors of Nuclear Export Block Pancreatic Cancer Cell Proliferation and Reduce Tumor Growth in Mice; Gastroenterology?144?447 3) Desisto?et al.?(2019),?Exportin 1 inhibition induces nerve growth factor receptor expression to inhibit the NF-kB pathway in preclinical models of pediatric high-grade glioma; Mol. Cancer Ther.?19 540 4) Aboukameel?et al. (2018),?Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression;?Oncotarget?9?35327 5) Baek?et al.?(2018),?XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies; Oncotarget?9?34567 6) Wahba?et al.?(2018),?The XPO1 Inhibitor Selinexor Inhibits Translation and Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and In Vivo; Mol. Cancer Ther.?17?1717 7) Arango?et al.?(2017),?Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer; Breast Cancer Res.?19?93 8) Conforti?et al.?(2017),?Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors; Cancer Res.?77?5614

KPT-330 Preparation Products And Raw materials

Raw materials

Preparation Products

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KPT-330 Suppliers

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View Lastest Price from KPT-330 manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Selinexor Kpt-330 1393477-72-9
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-12-30

Wuhan Nutra Biotechnology Co.,Ltd

Product: Selinexor;KPT-330 1393477-72-9
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%+
Supply Ability: 100kgs
Release date: 2021-05-21

Hangzhou ICH Biofarm Co., Ltd

Product: Selinexor 1393477-72-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200
Release date: 2023-07-17

1393477-72-9, KPT-330Related Search:

PD 173074 KPT-330, (E)-RN Verdinexor (KPT-335) Bortezomib (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3- MK-2206 2HCl OTX015 KPT-185 Ruxolitinib CONCANAMYCIN A Prostaglandin E2 SGC-GAK-1 2-BROMOHEXADECANOIC ACID 3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazole (Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid 2-Propenoic acid, 3-iodo-, 1-methylethyl ester, (2Z)- (Z)-isopropyl 3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

KPT-330

(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide

Selinexor

Selinexor (KPT-330)

(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide

2-Propenoic acid, 3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 2-(2-pyrazinyl)hydrazide, (2Z)-

Aloradine

KPT330,Selinexor

(KPT330)(Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide

SELINEXOR;KPT330;KPT 330

KPT-330,Selinexor, >98%

KPT330; KPT 330

CS-1056

(Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyrazin-2-ylprop-2-enehydrazide

(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide(Selinexor)

Selinexor free base

KPT-330 USP/EP/BP

Selinexor (KPT 330),Selinexor (KPT330)

Xpovio

(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide

Selinexorb

Avatrombopag Impurity 32 Hydrochloride

1393477-72-9

C17H11F6N7O

Inhibitors

API