KPT-185
- Product Name
- KPT-185
- CAS No.
- 1333151-73-7
- Chemical Name
- KPT-185
- Synonyms
- CS-844;KPT-185;KPT-185;KPT185;KPT-185, >=98%;KPT-185 USP/EP/BP;(Z)-Isopropyl 3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate;(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester;2-Propenoic acid, 3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 1-methylethyl ester, (2Z)-;(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester KPT185
- CBNumber
- CB32655409
- Molecular Formula
- C16H16F3N3O3
- Formula Weight
- 355.31
- MOL File
- 1333151-73-7.mol
KPT-185 Property
- Boiling point:
- 458.8±55.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥17.77 mg/mL in DMSO; ≥25.2 mg/mL in EtOH
- form
- solid
- pka
- 0.47±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 26074
- Product name
- KPT-185
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 26074
- Product name
- KPT-185
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 26074
- Product name
- KPT-185
- Packaging
- 25mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- B1462
- Product name
- KPT-185
- Packaging
- 10mg
- Price
- $68
- Updated
- 2021/12/16
- Product number
- B1462
- Product name
- KPT-185
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $60
- Updated
- 2021/12/16
KPT-185 Chemical Properties,Usage,Production
Uses
KPT185 acts as a novel CRM1 inhibitor used in the treatment of acute myeloid leukemia.
Biological Activity
kpt-185 is a selective and irreversible inhibitor of chromosome maintenance protein 1 (crm1) with ic50 values of 100-500nm [1].crm1 is an important nuclear protein export receptor. blocking crm1-mediated nuclear export can result in the suppression of tumors. as an inhibitor of crm1, kpt-185 binds crm1within the cys528 site and prevents crm1from interacting with tumor-suppressor proteins. in the in vitro studies on aml cell lines, kpt-185 inhibits proliferation of a variety of leukemia cells with ic50 values ranging from 100nm to 500nm. it induces cell-cycle arrest at g1 and induces apoptosis. kpt-185 also strongly affects cell colony formation. in addition, the inhibition of crm1 caused by kpt-185 induces differentiation of aml blast. besides that, kpt-185 is also found to inhibit proliferation and induce apoptosis of pancreatic cancer cells including colo-357, hpac and bxpc-3 [1, 2].
target
CRM1
References
[1] ranganathan p, yu x, na c, et al. preclinical activity of a novel crm1 inhibitor in acute myeloid leukemia. blood, 2012, 120(9): 1765-1773.
[2] azmi a s, aboukameel a, bao b, et al. selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice. gastroenterology, 2013, 144(2): 447-456.
KPT-185 Preparation Products And Raw materials
Raw materials
Preparation Products
KPT-185 Suppliers
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View Lastest Price from KPT-185 manufacturers
- Product
- KPT-185 1333151-73-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-10