ChemicalBook > CAS DataBase List > KPT-185

KPT-185

Product Name
KPT-185
CAS No.
1333151-73-7
Chemical Name
KPT-185
Synonyms
CS-844;KPT-185;KPT-185;KPT185;KPT-185, >=98%;KPT-185 USP/EP/BP;(Z)-Isopropyl 3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate;(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester;2-Propenoic acid, 3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 1-methylethyl ester, (2Z)-;(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester KPT185
CBNumber
CB32655409
Molecular Formula
C16H16F3N3O3
Formula Weight
355.31
MOL File
1333151-73-7.mol
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KPT-185 Property

Boiling point:
458.8±55.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥17.77 mg/mL in DMSO; ≥25.2 mg/mL in EtOH
form 
solid
pka
0.47±0.50(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26074
Product name
KPT-185
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
26074
Product name
KPT-185
Packaging
10mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
26074
Product name
KPT-185
Packaging
25mg
Price
$270
Updated
2024/03/01
ApexBio Technology
Product number
B1462
Product name
KPT-185
Packaging
10mg
Price
$68
Updated
2021/12/16
ApexBio Technology
Product number
B1462
Product name
KPT-185
Packaging
10mM(in 1mL DMSO)
Price
$60
Updated
2021/12/16
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KPT-185 Chemical Properties,Usage,Production

Uses

KPT185 acts as a novel CRM1 inhibitor used in the treatment of acute myeloid leukemia.

Biological Activity

kpt-185 is a selective and irreversible inhibitor of chromosome maintenance protein 1 (crm1) with ic50 values of 100-500nm [1].crm1 is an important nuclear protein export receptor. blocking crm1-mediated nuclear export can result in the suppression of tumors. as an inhibitor of crm1, kpt-185 binds crm1within the cys528 site and prevents crm1from interacting with tumor-suppressor proteins. in the in vitro studies on aml cell lines, kpt-185 inhibits proliferation of a variety of leukemia cells with ic50 values ranging from 100nm to 500nm. it induces cell-cycle arrest at g1 and induces apoptosis. kpt-185 also strongly affects cell colony formation. in addition, the inhibition of crm1 caused by kpt-185 induces differentiation of aml blast. besides that, kpt-185 is also found to inhibit proliferation and induce apoptosis of pancreatic cancer cells including colo-357, hpac and bxpc-3 [1, 2].

target

CRM1

References

[1] ranganathan p, yu x, na c, et al. preclinical activity of a novel crm1 inhibitor in acute myeloid leukemia. blood, 2012, 120(9): 1765-1773.
[2] azmi a s, aboukameel a, bao b, et al. selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice. gastroenterology, 2013, 144(2): 447-456.

KPT-185 Preparation Products And Raw materials

Raw materials

Preparation Products

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KPT-185 Suppliers

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View Lastest Price from KPT-185 manufacturers

Career Henan Chemical Co
Product
KPT-185 1333151-73-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-10

1333151-73-7, KPT-185Related Search:

(Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-1-(3,3- PD 0325901 Dabrafenib Trametinib Nutlin-3 KPT-330

  • 2-Propenoic acid, 3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 1-methylethyl ester, (2Z)-
  • (2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester KPT185
  • KPT-185
  • (2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester
  • KPT-185, >=98%
  • KPT-185;KPT185
  • (Z)-Isopropyl 3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate
  • CS-844
  • KPT-185 USP/EP/BP
  • 1333151-73-7
  • 133315-73-7
  • Inhibitors