Verdinexor (KPT-335)
- Product Name
- Verdinexor (KPT-335)
- CAS No.
- 1392136-43-4
- Chemical Name
- Verdinexor (KPT-335)
- Synonyms
- CS-1798;KPT-335;Verdinexor;KPT335(Verdinexor);Verdinexor(KPT-335);Verdinexor (KPT-335) USP/EP/BP;Z)-3-(3-(3,5-bis(trifluoroMethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyridin-;(Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-N'-pyridin-2-ylprop-2-enehydrazide;(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyridin-2-yl)acrylohydrazide;(Z)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyridin-2-yl)acrylohydrazide
- CBNumber
- CB02680705
- Molecular Formula
- C18H12F6N6O
- Formula Weight
- 442.32
- MOL File
- 1392136-43-4.mol
Verdinexor (KPT-335) Property
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥44.2 mg/mL in DMSO; insoluble in H2O; ≥2.31 mg/mL in EtOH with ultrasonic
- form
- solid
- pka
- 10.04±0.43(Predicted)
- color
- Light yellow to yellow
- CAS DataBase Reference
- 1392136-43-4
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26171
- Product name
- Verdinexor
- Packaging
- 1mg
- Price
- $29
- Updated
- 2024/03/01
- Product number
- 26171
- Product name
- Verdinexor
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 26171
- Product name
- Verdinexor
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- B4889
- Product name
- Verdinexor(KPT-335)
- Packaging
- 5mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- B4889
- Product name
- Verdinexor(KPT-335)
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $250
- Updated
- 2021/12/16
Verdinexor (KPT-335) Chemical Properties,Usage,Production
Uses
Verdinexor is a potent and selective SINE inhibitor, shown to be effective in treating influenza A virus infection in mice and ferret models.
Biological Activity
verdinexor (kpt-335) is a potent and selective inhibitor of nuclear export [1].nuclear export (sine) is mainly mediated by exportin 1 (xpo1) and mediates specific proteins out of the nucleus, which plays an important role in the regulation of proliferation and the cell cycle [2].verdinexor (kpt-335) is a potent and selective sine inhibitor that acts as an antiviral drug. in a549 cells inoculated with the influenza a and b virus, verdinexor effectively inhibited the replication of the influenza a and b virus strains tested. verdinexor (1 μm) caused the accumulation of vrnps in the nuclei and altered the localization of viral ns1. also, verdinexor increased nuclear negative-sense vrna by 56.6-fold and significantly reduced cytoplasmic negative-sense vrna, which suggested that verdinexor blocked vrnp nuclear export. in 293t cells, verdinexor inhibited xpo1-nep binding [1].in mice infected with influenza virus a, verdinexor significantly reduced lung influenza virus a titers. verdinexor also reduced the expression of proinflammatory cytokines tumor necrosis factor alpha, interleukin-6, interleukin-1β and gamma interferon. in mice infected with a lethal dose, verdinexor inhibited virus penetration of the respiratory tract and virus spread in the lungs [1]. in companion dogs with b- and t-cell lymphomas, verdinexor showed potent cytotoxic activity [2].
storage
Store at -20°C
References
[1]. perwitasari o, johnson s, yan x, et al. verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo. j virol, 2014, 88(17): 10228-10243.
[2]. gravina gl, senapedis w, mccauley d, et al. nucleo-cytoplasmic transport as a therapeutic target of cancer. j hematol oncol, 2014, 7: 85.
Verdinexor (KPT-335) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Verdinexor (KPT-335) manufacturers
- Product
- Verdinexor (KPT-335) 1392136-43-4
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-21