TYRPHOSTIN A9
- Product Name
- TYRPHOSTIN A9
- CAS No.
- 10537-47-0
- Chemical Name
- TYRPHOSTIN A9
- Synonyms
- AG 17;CS-743;SF 6847;gcp5126;s-15126;RG 50872;ent27910;MALONABEN;MALONOBEN;Malonobene
- CBNumber
- CB2245711
- Molecular Formula
- C18H22N2O
- Formula Weight
- 282.38
- MOL File
- 10537-47-0.mol
TYRPHOSTIN A9 Property
- Melting point:
- 141-143℃ (ethanol )
- Boiling point:
- 424.99°C (rough estimate)
- Density
- 1.0741 (rough estimate)
- refractive index
- 1.5700 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- ethanol: 20 mg/mL
- form
- solid
- pka
- 7.55±0.40(Predicted)
- color
- yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- CAS DataBase Reference
- 10537-47-0(CAS DataBase Reference)
- EPA Substance Registry System
- Malonoben (10537-47-0)
Safety
- Hazard Codes
- T
- Risk Statements
- 23/24/25
- Safety Statements
- 36/37/39-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- OO3737000
- HS Code
- 2926.90.5050
- HazardClass
- 6.1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- T182
- Product name
- Tyrphostin A9
- Purity
- solid
- Packaging
- 5mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- S481777
- Product name
- 2-(3,5-DI-TERT-BUTYL-4-HYDROXY-BENZYLIDENE)-MALONONITRILE
- Purity
- AldrichCPR
- Packaging
- 25MG
- Price
- $179
- Updated
- 2024/03/01
- Product number
- 658425
- Product name
- AG 17
- Packaging
- 5mg
- Price
- $85.2
- Updated
- 2024/03/01
- Product number
- T3667
- Product name
- Tyrphostin A9
- Purity
- >98.0%(GC)
- Packaging
- 25mg
- Price
- $69
- Updated
- 2024/03/01
- Product number
- T3667
- Product name
- Tyrphostin A9
- Purity
- >98.0%(GC)
- Packaging
- 100mg
- Price
- $206
- Updated
- 2024/03/01
TYRPHOSTIN A9 Chemical Properties,Usage,Production
Description
Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50?= 1.2 μM)1and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria.3 Tyrphostin 9 perturbs the golgi complex and blocks proliferation of vascular smooth muscle cells.4
Uses
Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.
Uses
SF 6847 is an inhibitor of EGFR with IC50 of 460 μM.
Uses
Selective inhibitor of PDGF receptor tyrosine kinase
Definition
ChEBI: Malonoben is an alkylbenzene. It has a role as a geroprotector.
General Description
A selective, cell-permeable, reversible, and substrate competitive inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM). Anti-proliferative agent. Uncoupler of oxidative phosphorylation. Induces apoptosis in vitro and cell growth arrest in NHL cell lines.
Biological Activity
Potent uncoupler of oxidative phosphorylation.
Biochem/physiol Actions
Cell permeable: yes
References
1) Bilder?et al. (1991),?Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells; Am. J. Physiol.,?260?C721 2) Terada?et al. (1981),?The interaction of highly active uncouplers with mitochondria; Biochim. Biophys. Acta,?639?225 3) Burger?et al. (1995),?Tyrphostin AG17, [3,5-Ditert-butyl-4-hydroxybenzylidene)-malononitrile], inhibits cell growth by disrupting mitochondria; Cancer Res.,?55?2794 4) Thyberg?et al. (1998),?Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells; Eur. J. Cell Biol.,?76?33
TYRPHOSTIN A9 Preparation Products And Raw materials
Raw materials
Preparation Products
TYRPHOSTIN A9 Suppliers
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View Lastest Price from TYRPHOSTIN A9 manufacturers
- Product
- TYRPHOSTIN A9OLECARBOXYLATE 10537-47-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- per week 100kg
- Release date
- 2019-09-05