TYRPHOSTIN B48

Product Name: TYRPHOSTIN B48
CAS No.: 133550-35-3
Chemical Name: TYRPHOSTIN B48
Synonyms: 494;AG 494;CS-2755;TYRPHOSTIN B48;-494 Tyrphostin;TYRPHOSTIN AG 494;AG-494 Tyrphostin;TyrphostinAG494>AG-494;AG 494;AG494;AG 494 (Tyrphostin AG 494)
CBNumber: CB9319132
Molecular Formula: C16H12N2O3
Formula Weight: 280.28
MOL File: 133550-35-3.mol

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TYRPHOSTIN B48 Property

Melting point:: 249 °C(dec.)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: soluble
form: Yellow solid.
color: Light yellow to Amber to Dark green

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Safety

Safety Statements: 22-24/25
RIDADR: 3439
WGK Germany: 3
HS Code: 2926.90.4801
HazardClass: 6.1
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2704
Product name: Tyrphostin AG 494
Purity: >98.0%(HPLC)(N)
Packaging: 20mg
Price: $91
Updated: 2024/03/01

TCI Chemical

Product number: A2704
Product name: Tyrphostin AG 494
Purity: >98.0%(HPLC)(N)
Packaging: 100mg
Price: $275
Updated: 2024/03/01

Cayman Chemical

Product number: 10010242
Product name: AG-494
Purity: ≥98%
Packaging: 5mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 10010242
Product name: AG-494
Purity: ≥98%
Packaging: 10mg
Price: $64
Updated: 2024/03/01

Cayman Chemical

Product number: 10010242
Product name: AG-494
Purity: ≥98%
Packaging: 25mg
Price: $150
Updated: 2024/03/01

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TYRPHOSTIN B48 Chemical Properties,Usage,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-494 is an inhibitor of epidermal growth factor receptor kinase with an IC₅₀ value of 1 μM in HT-22 cells.

Biological Activity

Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.7 μ M). Selective over ErbB2, PDGFR and insulin receptor kinase (IC 50 values are 42, 6 and > 100 μ M respectively).

References

[1]. osherov n, levitzki a. tyrphostin ag 494 blocks cdk2 activation. febs lett, 1997, 410(2-3): 187-190.
[2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[3]. liu x, qin j, luo q, et al. cross-talk between egf and bmp9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. j cell mol med, 2013, 17(9): 1160-1172.
[4]. bojko a1, reichert k, adamczyk a, et al. the effect of tyrphostins ag494 and ag1478 on the autocrine growth regulation of a549 and du145 cells. folia histochem cytobiol, 2012, 50(2): 186-195.

TYRPHOSTIN B48 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN B48 Suppliers

Americas 1 China 79 Europe 1 Germany 2 India 1 Japan 1 Switzerland 2 United Kingdom 5 United States 19 Global 111

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
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Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
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Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
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TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
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TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

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View Lastest Price from TYRPHOSTIN B48 manufacturers

Career Henan Chemical Co

Product: TYRPHOSTIN B48 133550-35-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-24

133550-35-3, TYRPHOSTIN B48Related Search:

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(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-PHENYL-2-PROPENAMIDE

ALPHA-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE

A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMAMIDE

A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE

AG 494

N-PHENYL-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE

TYRPHOSTIN B48

TYRPHOSTIN AG 494

N-Phenyl-3,4-dihydroxybenzylidenecyanoacetamide, Tyrphostin B48

AG 494 (Tyrphostin AG 494)

(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-phenyl-2-propenamide

(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide

-2-Cyano-3-(3,4-dihydroxyphenyl)

AG-494;AG 494;AG494

CS-2755

TyrphostinAG494&gt

2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-, (2E)-

494

-494 Tyrphostin

AG-494 Tyrphostin

DNA,ErbB-1,differentiation,Epidermal growth factor receptor,Cyclin dependent kinase,EGFR,HER1,Inhibitor,CDK,autophosphorylation,osteogenic,synthesis,Tyrphostin AG494,Tyrphostin AG 494,AG-494,activation,inhibit,Cdk2,AG494

133550-35-3

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Receptor Tyrosine Kinase Inhibitors

Kinase/Phosphatase Biology

Epidermal Growth Factor Receptor (EGFR)

API

Intracellular Signaling

Protein Kinase