ChemicalBook > CAS DataBase List > TYRPHOSTIN B48

TYRPHOSTIN B48

Product Name
TYRPHOSTIN B48
CAS No.
133550-35-3
Chemical Name
TYRPHOSTIN B48
Synonyms
494;AG 494;A -494;CS-2755;TYRPHOSTIN B48;-494 Tyrphostin;TYRPHOSTIN AG 494;AG-494 Tyrphostin;TyrphostinAG494>AG-494;AG 494;AG494
CBNumber
CB9319132
Molecular Formula
C16H12N2O3
Formula Weight
280.28
MOL File
133550-35-3.mol
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TYRPHOSTIN B48 Property

Melting point:
249 °C(dec.)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO: soluble
form 
Yellow solid.
color 
Light yellow to Amber to Dark green
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Safety

Safety Statements 
22-24/25
RIDADR 
3439
WGK Germany 
3
HS Code 
2926.90.4801
HazardClass 
6.1
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2704
Product name
Tyrphostin AG 494
Purity
>98.0%(HPLC)(N)
Packaging
20mg
Price
$91
Updated
2024/03/01
TCI Chemical
Product number
A2704
Product name
Tyrphostin AG 494
Purity
>98.0%(HPLC)(N)
Packaging
100mg
Price
$275
Updated
2024/03/01
Cayman Chemical
Product number
10010242
Product name
AG-494
Purity
≥98%
Packaging
5mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
10010242
Product name
AG-494
Purity
≥98%
Packaging
10mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
10010242
Product name
AG-494
Purity
≥98%
Packaging
25mg
Price
$150
Updated
2024/03/01
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TYRPHOSTIN B48 Chemical Properties,Usage,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-494 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 μM in HT-22 cells.

Biological Activity

Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.7 μ M). Selective over ErbB2, PDGFR and insulin receptor kinase (IC 50 values are 42, 6 and > 100 μ M respectively).

References

[1]. osherov n, levitzki a. tyrphostin ag 494 blocks cdk2 activation. febs lett, 1997, 410(2-3): 187-190.
[2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[3]. liu x, qin j, luo q, et al. cross-talk between egf and bmp9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. j cell mol med, 2013, 17(9): 1160-1172.
[4]. bojko a1, reichert k, adamczyk a, et al. the effect of tyrphostins ag494 and ag1478 on the autocrine growth regulation of a549 and du145 cells. folia histochem cytobiol, 2012, 50(2): 186-195.

TYRPHOSTIN B48 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN B48 Suppliers

Americas 1 China 79 Europe 1 Germany 2 India 1 Japan 1 Switzerland 2 United Kingdom 5 United States 20 Global 112
3B Pharmachem (Wuhan) International Co.,Ltd.
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View Lastest Price from TYRPHOSTIN B48 manufacturers

Career Henan Chemical Co
Product
TYRPHOSTIN B48 133550-35-3
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-24

133550-35-3, TYRPHOSTIN B48Related Search:

TYRPHOSTIN A9 Canertinib TYRPHOSTIN AG 835 TYRPHOSTIN A1 AG 490 TYRPHOSTIN AG 528 TYRPHOSTIN B48 Tyrphostin A48, 3-Amino-2,4-dicyano-5-(4μ-hydroxyphenyl)penta-2,4-dienonitrile,TYRPHOSTIN A48 TYRPHOSTIN B48 TIMTEC-BB SBB006283 AURORA 9522 AURORA 9504 AURORA 8967 AURORA 9549 AURORA 9545 AURORA 9521 AURORA 9859 AURORA 1302

  • (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-PHENYL-2-PROPENAMIDE
  • ALPHA-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE
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  • TYRPHOSTIN B48
  • TYRPHOSTIN AG 494
  • N-Phenyl-3,4-dihydroxybenzylidenecyanoacetamide, Tyrphostin B48
  • AG 494 (Tyrphostin AG 494)
  • (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-phenyl-2-propenamide
  • (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide
  • -2-Cyano-3-(3,4-dihydroxyphenyl)
  • AG-494;AG 494;AG494
  • CS-2755
  • TyrphostinAG494&gt
  • 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-, (2E)-
  • 494
  • -494 Tyrphostin
  • AG-494 Tyrphostin
  • DNA,ErbB-1,differentiation,Epidermal growth factor receptor,Cyclin dependent kinase,EGFR,HER1,Inhibitor,CDK,autophosphorylation,osteogenic,synthesis,Tyrphostin AG494,Tyrphostin AG 494,AG-494,activation,inhibit,Cdk2,AG494
  • A -494
  • AG-494, EGF receptor tyrosine kinase
  • 133550-35-3
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Receptor Tyrosine Kinase Inhibitors
  • Kinase/Phosphatase Biology
  • Epidermal Growth Factor Receptor (EGFR)
  • API
  • Intracellular Signaling
  • Protein Kinase