ChemicalBook > CAS DataBase List > TYRPHOSTIN A9

TYRPHOSTIN A9

Product Name
TYRPHOSTIN A9
CAS No.
10537-47-0
Chemical Name
TYRPHOSTIN A9
Synonyms
AG 17;CS-743;SF 6847;gcp5126;s-15126;RG 50872;ent27910;MALONABEN;MALONOBEN;Malonobene
CBNumber
CB2245711
Molecular Formula
C18H22N2O
Formula Weight
282.38
MOL File
10537-47-0.mol
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TYRPHOSTIN A9 Property

Melting point:
141-143℃ (ethanol )
Boiling point:
424.99°C (rough estimate)
Density 
1.0741 (rough estimate)
refractive index 
1.5700 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
ethanol: 20 mg/mL
form 
solid
pka
7.55±0.40(Predicted)
color 
yellow
biological source
synthetic (organic)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
CAS DataBase Reference
10537-47-0(CAS DataBase Reference)
EPA Substance Registry System
Malonoben (10537-47-0)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
OO3737000
HS Code 
2926.90.5050
HazardClass 
6.1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T182
Product name
Tyrphostin A9
Purity
solid
Packaging
5mg
Price
$114
Updated
2025/07/31
Sigma-Aldrich
Product number
S481777
Product name
2-(3,5-DI-TERT-BUTYL-4-HYDROXY-BENZYLIDENE)-MALONONITRILE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$185
Updated
2025/07/31
Sigma-Aldrich
Product number
S481777
Product name
2-(3,5-DI-TERT-BUTYL-4-HYDROXY-BENZYLIDENE)-MALONONITRILE
Purity
AldrichCPR
Packaging
25MG
Price
$179
Updated
2024/03/01
Sigma-Aldrich
Product number
658425
Product name
AG 17
Packaging
5mg
Price
$85.2
Updated
2024/03/01
TCI Chemical
Product number
T3667
Product name
Tyrphostin A9
Purity
>98.0%(GC)
Packaging
25mg
Price
$69
Updated
2025/07/31
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TYRPHOSTIN A9 Chemical Properties,Usage,Production

Description

Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50?= 1.2 μM)1and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria.3 Tyrphostin 9 perturbs the golgi complex and blocks proliferation of vascular smooth muscle cells.4

Uses

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.

Uses

SF 6847 is an inhibitor of EGFR with IC50 of 460 μM.

Uses

Selective inhibitor of PDGF receptor tyrosine kinase

Definition

ChEBI: Malonoben is an alkylbenzene. It has a role as a geroprotector.

General Description

A selective, cell-permeable, reversible, and substrate competitive inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM). Anti-proliferative agent. Uncoupler of oxidative phosphorylation. Induces apoptosis in vitro and cell growth arrest in NHL cell lines.

Biological Activity

Potent uncoupler of oxidative phosphorylation.

Biochem/physiol Actions

Cell permeable: yes

References

[1] G E BILDER. Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells.[J]. American Journal of Physiology, 1991, 260 4 Pt 1: C721-30. DOI:10.1152/ajpcell.1991.260.4.c721
[2] TERADA H. The interaction of highly active uncouplers with mitochondria[J]. Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, 1981, 639 3: Pages 225-242. DOI:10.1016/0304-4173(81)90011-2
[3] A M BURGER. Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)- malononitrile], inhibits cell growth by disrupting mitochondria.[J]. Cancer research, 1995, 55 13: 2794-2799.
[4] THYBERG J. Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells[J]. European journal of cell biology, 1998, 76 1: Pages 33-42. DOI:10.1016/s0171-9335(98)80015-0

TYRPHOSTIN A9 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN A9 Suppliers

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View Lastest Price from TYRPHOSTIN A9 manufacturers

Career Henan Chemical Co
Product
TYRPHOSTIN A9OLECARBOXYLATE 10537-47-0
Price
US $1.00/KG
Min. Order
1KG
Purity
95%~99%
Supply Ability
per week 100kg
Release date
2019-09-05

10537-47-0, TYRPHOSTIN A9Related Search:

TYRPHOSTIN 25,TYRPHOSTIN A25 TYRPHOSTIN A23,TYRPHOSTIN 23,AG 18 (Tyrphostin A23) TYRPHOSTIN 63,TYRPHOSTIN A63 TYRPHOSTIN A1,TYRPHOSTIN 1 TYRPHOSTIN A51,TYRPHOSTIN 51 AG 213 (Tyrphostin AG 213),TYRPHOSTIN 47,TYRPHOSTIN A47 TYRPHOSTIN AG 1288 TYRPHOSTIN AG 835 TYRPHOSTIN AG 528 TYRPHOSTIN A10 AG 494 (Tyrphostin AG 494) AG 490 (Tyrphostin AG 490) TYRPHOSTIN A9 AG 490 AG 1478 TYRPHOSTIN 957 AG 1295 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)

  • ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)CINNAMONITRILE
  • TYRPHOSTIN A9 \ SELECTIVE PDGF TYROSINE
  • TYRPHOSTIN A9 99+%
  • Malonobene
  • 2-(3,5-di-tert-butyl-4-hydroxybenzylidene)Malononitrile
  • Tyrphostin 9 (SF 6847)
  • Propanedinitrile, 2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-
  • [[3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENYL]METHYLENE]-PROPANEDINITRILE
  • 3,5-DI-T-BUTYL-4-HYDROXY-BENZYLIDENEMALONONITRILE
  • 3,5-DI-TERT-BUTYL-4-HYDROXYBENZYLIDENEMALONONITRILE
  • AG 17
  • 2-[(3,5-DITERT-BUTYL-4-HYDROXYPHENYL)METHYLIDENE]PROPANEDINITRILE
  • Tyrphostin A9 (AG 17)
  • 2,6-Di-tert-butyl-4-(2,2-dicyanovinyl)phenol
  • 3,5-di-tert-Butyl-4-hydroxybenzylidenemalonitrile
  • Tyrphostin 9/AG9
  • TYRPHOSTIN 9;NSC 242557; RG-50872;AG 17; GCP 5126
  • Tyrphostin 9 (RG-50872, Malonaben, SF 6847)
  • NSC 242557
  • SF 6847
  • RARECHEM AL BX 0198
  • RG 50872
  • ((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-propanedinitril
  • 2-((3,5-bis(1,1-dimethyl)-4-hydroxyphenyl)methylene)propanedinitrile
  • 3,5-di-tert-butyl-4-hydroxybenzylidene-malononitril
  • ent27910
  • gcp5126
  • gulfs-15126
  • s-15126
  • TYRPHOSTIN 9
  • TYRPHOSTIN A9
  • TYRPHOSTIN AG 17
  • TYRPHOSTIN RG 50872
  • CHEMBRDG-BB 5272363
  • MALONABEN
  • MALONOBEN
  • AG 17 - CAS 10537-47-0 - Calbiochem
  • Tyrphostin 9(AG-17)
  • TYRPHOSTIN 9;MALONOBEN;TYRPHOSTIN AG-17;SF 6847;GCP 5126;RG-50872;NSC 242557
  • CS-743
  • Tyrphostin9, >98%
  • TYRPHOSTIN A9OLECARBOXYLATE
  • Tyrphostin 9 (SF 6847, RG-50872)
  • [4-Hydroxy-3,5-bis(2-methyl-2-propanyl)benzylidene]malononitrile
  • TYRPHOSTIN A9 USP/EP/BP
  • Malonoben Tyrphostin 9
  • C17896100 Tyrphostin A9
  • Tyrphostin 9, PDGFR tyrosine kinase inhibitor
  • Tyrphostin A9, 10 mM in DMSO
  • Tyrphostin 9 ，S2895
  • 10537-47-0
  • Inhibitor of calcium release-activated calcium (CRAC) channels (see Dennis et al)
  • Cell Signaling and Neuroscience
  • BioChemical
  • Cell Biology
  • Kinase/Phosphatase Biology
  • Receptor Tyrosine Kinase Inhibitors
  • Platelet Derived Growth Factor Receptor (PDGFR)