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AG 1295

Product Name
AG 1295
CAS No.
71897-07-9
Chemical Name
AG 1295
Synonyms
AG 1295;NSC 380341;AG 1295 USP/EP/BP;TYRPHOSTIN AG 1295;TYROPHOSTIN AG1295;AG-1295 (NSC 380341;TYRPHOSTIN AG 1295, 99+%;AG 1295 PLATELET-DERIVED GROW;6,7-DIMETHYL-2-PHENYLQUINOXALINE;Quinoxaline, 6,7-dimethyl-2-phenyl-
CBNumber
CB5683675
Molecular Formula
C16H14N2
Formula Weight
234.3
MOL File
71897-07-9.mol
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AG 1295 Property

Melting point:
121 °C
Boiling point:
398.3±37.0 °C(Predicted)
Density 
1.127±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
White solid
pka
1.29±0.30(Predicted)
color 
Yellow
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
658550
Product name
AG 1295
Packaging
5mg
Price
$159
Updated
2024/03/01
Sigma-Aldrich
Product number
R365327
Product name
6,7-DIMETHYL-2-PHENYL-QUINOXALINE
Purity
AldrichCPR
Packaging
25MG
Price
$28.6
Updated
2023/06/20
Cayman Chemical
Product number
14529
Product name
AG 1295
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
14529
Product name
AG 1295
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
14529
Product name
AG 1295
Purity
≥98%
Packaging
10mg
Price
$184
Updated
2024/03/01
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AG 1295 Chemical Properties,Usage,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1295 is a quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGF receptor kinase in vitro and in Swiss 3T3 cells (IC50s range from 0.3-1 μM). It inhibits PDGF-stimulated DNA synthesis with an IC50 value of 2.5 μM without affecting activity of the EGF receptor.

Uses

AG-1295 is a protein tyrosine kinase inhibitor. Antiproliferative agent used in the treatment of atherosclerosis, pulmonary fibrosis, and gliomas.

Definition

ChEBI: 6,7-dimethyl-2-phenylquinoxaline is a quinoxaline derivative. It has a role as a geroprotector.

in vitro

the previous study investigated the effect of pdgf receptor-beta (pdgfr-β) inhibition by ag-1295 on the osteogenic differentiation of the mouse pre-osteoblastic cell line mc3t3-e1. results showed that ag-1295 could significantly increase the alkaline phosphatase (alp) activity and enhance the formation of mineralized nodules dose-dependently. moreover, the treatment with ag-1295 led to the up-regulated mrna expression of the osteogenic marker genes collagen type i, runt-related transcription factor 2, osterix, tissue-nonspecific alkaline phosphatase, as well as osteocalcin. consistent with its effect on osteoblast differentiation, ag-1295 was also able to significantly suppress the phosphorylation of erk1/2 in mc3t3-e1 cells [1].

in vivo

a previous animal study was designed to evaluated the possible effects of ag1295 on the development of interstitial fibrosis in rats with unilateral ureteral obstruction, monitored by ed-a+ fibronectin expression, the number of macrophages. results showed that the i.p.treatment with ag1295 at 12 mg/kg could significantly reduce interstitial fibrosis as verified by a smaller sirius-red stained area and also by a reduced number of macrophages, and by the ed-a+ fibronectin deposition and the number of cells positive for α-smooth muscle actin [2].

IC 50

0.3-1 μm for pdgf receptor kinase in vitro and in swiss 3t3 cells

References

[1] zhang yy, cui yz, luan j, zhou xy, zhang gl, han jx. platelet-derived growth factor receptor kinase inhibitor ag-1295 promotes osteoblast differentiation in mc3t3-e1 cells via the erk pathway. biosci trends. 2012 jun;6(3):130-5.
[2] ludewig d, kosmehl h, sommer m, bhmer fd, stein g. pdgf receptor kinase blocker ag1295 attenuates interstitial fibrosis in rat kidney after unilateral obstruction. cell tissue res. 2000 jan;299(1):97-103.

AG 1295 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 1295 Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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76
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
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60
Struchem Co., Ltd.
Tel
0512-0512-63009836 15365350169
Fax
0512-63006936
Email
helen@struchem.com
Country
China
ProdList
3984
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
56902
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
23225
Advantage
58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22963
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58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39894
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
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View Lastest Price from AG 1295 manufacturers

Career Henan Chemical Co
Product
AG 1295 71897-07-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98-100%
Supply Ability
1000kg
Release date
2018-08-20

71897-07-9, AG 1295Related Search:


  • 6,7-DIMETHYL-2-PHENYLQUINOXALINE
  • AG 1295
  • TYROPHOSTIN AG1295
  • TYRPHOSTIN AG 1295
  • AG 1295 PLATELET-DERIVED GROW
  • TYRPHOSTIN AG 1295, 99+%
  • Quinoxaline, 6,7-dimethyl-2-phenyl-
  • AG-1295 (NSC 380341
  • NSC 380341
  • AG 1295 USP/EP/BP
  • Platelet-derived growth factor receptor,RTK,AG 1295,inhibit,PDGF-receptor,AG-1295,autophosphorylation,Inhibitor,AG1295,PDGFR
  • 71897-07-9
  • 70897-07-9
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Kinase/Phosphatase Biology
  • Receptor Tyrosine Kinase Inhibitors
  • Platelet Derived Growth Factor Receptor (PDGFR)