NS-398

Product Name: NS-398
CAS No.: 123653-11-2
Chemical Name: NS-398
Synonyms: NS NS;NS-398;CS-2231;NS-398 98%;Taisho NS 398;NS-398 (NS 398;NS-398 USP/EP/BP;NS-398 - CAS 123653-11-2 - Calbiochem;Inhibitor,inhibit,NS-398,NS 398,COX,Cyclooxygenase;N-[2-(cyclohexoxy)-4-nitro-phenyl]methanesulfonamide
CBNumber: CB1754593
Molecular Formula: C13H18N2O5S
Formula Weight: 314.36
MOL File: 123653-11-2.mol

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NS-398 Property

Melting point:: 124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boiling point:: 490.6±55.0 °C(Predicted)
Density: 1.377±0.06 g/cm3(Predicted)
RTECS: PB0473500
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: >5 mg/mL
form: solid
pka: 6.33±0.10(Predicted)
color: off-white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2935.90.9500

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N194
Product name: NS-398
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $110.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 349254
Product name: NS-398
Purity: A cell-permeable selective inhibitor of COX-2
Packaging: 5mg
Price: $216
Updated: 2024/03/01

TCI Chemical

Product number: N1152
Product name: NS-398
Packaging: 10MG
Price: $113
Updated: 2024/03/01

TCI Chemical

Product number: N1152
Product name: NS-398
Packaging: 50MG
Price: $411
Updated: 2024/03/01

Alfa Aesar

Product number: J67313
Product name: NS-398, 98%
Packaging: 5mg
Price: $97.1
Updated: 2023/06/20

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NS-398 Chemical Properties,Usage,Production

Description

NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC₅₀ values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively. The IC₅₀ values for ovine COX-1 and -2 are 220 and 0.15 μM, respectively.

Uses

NS-398 is a selective Cox-2 inhibitor neuroprotective agent.

Definition

ChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.

Biological Activity

Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .

storage

Store at RT

References

[1]. futaki n, takahashi s, yokoyama m, et al. ns-398, a new anti-inflammatory agent, selectively inhibits prostaglandin g/h synthase/cyclooxygenase (cox-2) activity in vitro. prostaglandins, 1994, 47(1): 55-59.
[2]. elder dj, halton de, crew te, et al. apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug ns-398. int j cancer, 2000, 86(4): 553-560.
[3]. mack strong ve, mackrell pj, concannon em, et al. ns-398 treatment after trauma modifies nf-kappab activation and improves survival. j surg res, 2001, 98(1): 40-46.

NS-398 Preparation Products And Raw materials

Raw materials

Preparation Products

Glyoxal Acrylamide

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NS-398 Suppliers

Americas 1 China 101 Europe 1 Germany 2 India 3 Japan 4 Switzerland 3 United Kingdom 5 United States 24 Global 144

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 4257
Advantage: 58

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Ascent Scientific

Tel: 4401179829988
Fax: 4402030 700 369
Email: customerservice@ascentscientific.co.uk
Country: United Kingdom
ProdList: 279
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12990
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28398
Advantage: 80

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View Lastest Price from NS-398 manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: NS-398 123653-11-2
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000
Release date: 2024-03-22

Hebei Yanxi Chemical Co., Ltd.

Product: NS-398 123653-11-2
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-11-28

Hebei Mojin Biotechnology Co., Ltd

Product: NS-398 123653-11-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-12-04

123653-11-2, NS-398Related Search:

CALPHOSTIN C Trypsin inhibitor Potassium heptadecafluoro-1-octanesulfonate Pentasodium DTPA AG 18 AG 490 TYRPHOSTIN A25 Roscovitine Potassium clavulanate Ancymidol NS-398 3-ISOPROPOXYANILINE 4-NITRO-2-PROPOXY-PHENYLAMINE 4-NITRO METHANESULFONANILIDE 4-nitro-o-phenetidine N-(2-METHOXY-4-NITRO-PHENYL)-METHANESULFONAMIDE NS-398 (N-(2-Cyclohexyloxy-4-nitrophenyl) -Methanesulfonamide) Methanesulfonamide, N-(2-ethoxyphenyl)- (9CI)

CS-2231

NS-398 (NS 398

NS-398 - CAS 123653-11-2 - Calbiochem

NS-398

N-[2-(CYCLOHEXYLOXY)-4-NITROPHENYL]-METHANESULFONAMIDE

NS-398 98%

N-[2-(cyclohexoxy)-4-nitro-phenyl]methanesulfonamide

Taisho NS 398

NS 398; NS398; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANE SULFONAMIDE

NS NS

Methanesulfonamide, N-[2-(cyclohexyloxy)-4-nitrophenyl]-

NS-398 USP/EP/BP

Inhibitor,inhibit,NS-398,NS 398,COX,Cyclooxygenase

123653-11-2

123652-11-2

Cyclooxygenase (COX) Enzymes

Cyclooxygenase Inhibitors

Enzymes, Inhibitors, and Substrates

Biochemicals and Reagents

Cell Signaling Enzymes

BioChemical

Application Index

Signalling

NF-κB Signaling

Lipid signaling