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NS-398

Product Name
NS-398
CAS No.
123653-11-2
Chemical Name
NS-398
Synonyms
NS NS;NS-398;CS-2231;NS-398 98%;Taisho NS 398;NS-398 (NS 398;NS-398 USP/EP/BP;glycolysis inhibitor;mitochondrial complex I inhibitor;mitochondrial complex III inhibitor
CBNumber
CB1754593
Molecular Formula
C13H18N2O5S
Formula Weight
314.36
MOL File
123653-11-2.mol
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NS-398 Property

Melting point:
124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boiling point:
490.6±55.0 °C(Predicted)
Density 
1.377±0.06 g/cm3(Predicted)
RTECS 
PB0473500
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: >5 mg/mL
form 
solid
pka
6.33±0.10(Predicted)
color 
off-white
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
2935.90.9500
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N194
Product name
NS-398
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$110.4
Updated
2024/03/01
Sigma-Aldrich
Product number
349254
Product name
NS-398
Purity
A cell-permeable selective inhibitor of COX-2
Packaging
5mg
Price
$216
Updated
2024/03/01
TCI Chemical
Product number
N1152
Product name
NS-398
Packaging
10MG
Price
$113
Updated
2024/03/01
TCI Chemical
Product number
N1152
Product name
NS-398
Packaging
50MG
Price
$411
Updated
2024/03/01
Alfa Aesar
Product number
J67313
Product name
NS-398, 98%
Packaging
5mg
Price
$97.1
Updated
2023/06/20
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NS-398 Chemical Properties,Usage,Production

Description

NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively. The IC50 values for ovine COX-1 and -2 are 220 and 0.15 μM, respectively.

Uses

NS-398 is a selective Cox-2 inhibitor neuroprotective agent.

Definition

ChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.

Biological Activity

Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .

storage

Store at RT

References

[1]. futaki n, takahashi s, yokoyama m, et al. ns-398, a new anti-inflammatory agent, selectively inhibits prostaglandin g/h synthase/cyclooxygenase (cox-2) activity in vitro. prostaglandins, 1994, 47(1): 55-59.
[2]. elder dj, halton de, crew te, et al. apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug ns-398. int j cancer, 2000, 86(4): 553-560.
[3]. mack strong ve, mackrell pj, concannon em, et al. ns-398 treatment after trauma modifies nf-kappab activation and improves survival. j surg res, 2001, 98(1): 40-46.

NS-398 Preparation Products And Raw materials

Raw materials

Preparation Products

Glyoxal Acrylamide
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NS-398 Suppliers

Americas 1 China 107 Europe 1 Germany 2 India 3 Japan 4 Switzerland 3 United Kingdom 5 United States 25 Global 151
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Nacalai Tesque, Inc.
Tel
--
Fax
--
Email
info-tech@nacalai.co.jp
Country
Japan
ProdList
6046
Advantage
75
Wako Pure Chemical Industries, Ltd.
Tel
--
Fax
--
Email
labchem-tec@wako-chem.co.jp
Country
Japan
ProdList
6819
Advantage
80
Kanto Chemical Co., Inc.
Tel
--
Fax
--
Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
Advantage
74
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View Lastest Price from NS-398 manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
NS-398 123653-11-2
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2024-03-22
Hebei Yanxi Chemical Co., Ltd.
Product
NS-398 123653-11-2
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-11-28
Hebei Weibang Biotechnology Co., Ltd
Product
NS-398 123653-11-2
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24

123653-11-2, NS-398Related Search:

CALPHOSTIN C Trypsin inhibitor Potassium heptadecafluoro-1-octanesulfonate Pentasodium DTPA AG 18 AG 490 TYRPHOSTIN A25 Roscovitine Potassium clavulanate Ancymidol NS-398 3-ISOPROPOXYANILINE 4-NITRO-2-PROPOXY-PHENYLAMINE 4-NITRO METHANESULFONANILIDE 4-nitro-o-phenetidine N-(2-METHOXY-4-NITRO-PHENYL)-METHANESULFONAMIDE NS-398 (N-(2-Cyclohexyloxy-4-nitrophenyl) -Methanesulfonamide) Methanesulfonamide, N-(2-ethoxyphenyl)- (9CI)

  • CS-2231
  • NS-398 (NS 398
  • NS-398 - CAS 123653-11-2 - Calbiochem
  • NS-398
  • N-[2-(CYCLOHEXYLOXY)-4-NITROPHENYL]-METHANESULFONAMIDE
  • NS-398 98%
  • N-[2-(cyclohexoxy)-4-nitro-phenyl]methanesulfonamide
  • Taisho NS 398
  • NS 398; NS398; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANE SULFONAMIDE
  • NS NS
  • Methanesulfonamide, N-[2-(cyclohexyloxy)-4-nitrophenyl]-
  • NS-398 USP/EP/BP
  • Inhibitor,inhibit,NS-398,NS 398,COX,Cyclooxygenase
  • mitochondrial complex I inhibitor
  • mitochondrial complex III inhibitor
  • glycolysis inhibitor
  • 123653-11-2
  • 123652-11-2
  • Cyclooxygenase (COX) Enzymes
  • Cyclooxygenase Inhibitors
  • Enzymes, Inhibitors, and Substrates
  • Biochemicals and Reagents
  • Cell Signaling Enzymes
  • BioChemical
  • Application Index
  • Signalling
  • NF-κB Signaling
  • Lipid signaling