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CALPHOSTIN C

Product Name
CALPHOSTIN C
CAS No.
121263-19-2
Chemical Name
CALPHOSTIN C
Synonyms
UCN-1028C;2-Diazole;PKF 115-584;CALPHOSTIN C;Cladochrome E;(R)-Calphostin C;Calphostin C,98%;He Ding C Carver;Calphostin CUCN-1028C;UCN 1028 C, PKF 115-384
CBNumber
CB7457711
Molecular Formula
C44H38O14
Formula Weight
790.76
MOL File
121263-19-2.mol
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CALPHOSTIN C Property

Boiling point:
1039.8±65.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMF: 1 mg/mL
form 
powder
pka
7.30±0.20(Predicted)
color 
red to brown
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
3
HS Code 
29209010
Hazardous Substances Data
121263-19-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C6303
Product name
Calphostin C from Cladosporium cladosporioides
Purity
≥90% (HPLC), powder
Packaging
0.1mg
Price
$254.4
Updated
2024/03/01
Sigma-Aldrich
Product number
C6303
Product name
Calphostin C from Cladosporium cladosporioides
Purity
≥90% (HPLC), powder
Packaging
1mg
Price
$812
Updated
2024/03/01
Sigma-Aldrich
Product number
208725
Product name
Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem
Purity
Acellpermeable,highlyspecificinhibitorofproteinkinaseC(IC??=50nM)t
Packaging
50μg
Price
$154
Updated
2023/01/07
Sigma-Aldrich
Product number
208725
Product name
Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem
Purity
Acellpermeable,highlyspecificinhibitorofproteinkinaseC(IC??=50nM)t
Packaging
100μg
Price
$264
Updated
2023/01/07
Alfa Aesar
Product number
J60647
Product name
Calphostin C, 95%
Packaging
100microg
Price
$238
Updated
2023/06/20
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CALPHOSTIN C Chemical Properties,Usage,Production

Chemical Properties

Dark red solid

Uses

Calphostin C (CGP049090) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.

Uses

Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.

Uses

Potent inhibitor of protein kinase C

Biological Activity

Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM).

Biochem/physiol Actions

Highly specific inhibitor of protein kinase C (IC50 = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.

storage

+4°C (desiccate)

CALPHOSTIN C Preparation Products And Raw materials

Raw materials

Preparation Products

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CALPHOSTIN C Suppliers

J & K SCIENTIFIC LTD.
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Thermo Fisher Scientific
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ChemStrong Scientific Co.,Ltd
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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EMMX Biotechnology LLC
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888-539-0666
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info@emmx.com
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United States
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121263-19-2, CALPHOSTIN CRelated Search:


  • CALPHOSTIN C
  • CALPHOSTIN C FROM CLADOSPORIUMCLADOSPORI OIDES
  • UCN-1028C
  • (R)-Calphostin C
  • 1-[(R)-2-(4-Hydroxyphenoxycarbonyloxy)propyl]-2,6,7,11-tetramethoxy-4,9-dihydroxy-12-[(R)-2-(benzoyloxy)propyl]-3,10-dihydroperylene-3,10-dione
  • 4,9-Dihydroxy-12-[(R)-2-(4-hydroxyphenyloxy)carbonyloxypropyl]-2,6,7,11-tetramethoxy-1-[(R)-2-benzoyloxypropyl]perylene-3,10-dione
  • Calphostin C,98%
  • Calphostin CUCN-1028C
  • (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonicacid4-hydroxyphenylester
  • Calphostin C(UCN 1028C, PKF 115584)
  • C,CalphostinCfroMCladosporiuMcladosporioide
  • CALPHOSTIN C, CLADOSPORIUM CLADOSPORIOIDES
  • 2-[12-[2-(BENZOYLOXY)PROPYL]-3,10-DIHYDRO-4,9-DIHYDROXY-2,6,7,11-TETRAMETHOX Y-3,10-DIOXO-1-PERYLENYL]-1-METHYLETHYL CARBONIC ACID 4-HYDROXYPHENYL ESTER
  • UCN 1028 C, PKF 115-384
  • Cladochrome E
  • PKF 115-584
  • Calphostin C, 95.0+ % (HPLC)
  • (1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethyl 4-carbonic
  • He Ding C Carver
  • Carbonic acid,(1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethyl4-hydroxyphenyl ester, stereoisomer
  • Calphostin C DISCONTINUED
  • 2-Diazole
  • 121263-19-2
  • C44H38O14
  • Kinase/Phosphatase Biology
  • Serine/Threonine Kinase Inhibitors
  • Protein Kinase C (PKC)
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience