ChemicalBook > CAS DataBase List > CALPHOSTIN C

CALPHOSTIN C

Product Name: CALPHOSTIN C
CAS No.: 121263-19-2
Chemical Name: CALPHOSTIN C
Synonyms: UCN-1028C;2-Diazole;PKF 115-584;CALPHOSTIN C;Cladochrome E;CAS:121263-19-2;(R)-Calphostin C;Calphostin C,98%;He Ding C Carver;Calphostin CUCN-1028C
CBNumber: CB7457711
Molecular Formula: C44H38O14
Formula Weight: 790.76
MOL File: 121263-19-2.mol

Less

CALPHOSTIN C Property

Boiling point:: 1039.8±65.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMF: 1 mg/mL
form: powder
pka: 7.30±0.20(Predicted)
color: red to brown
biological source: microbial (Cladosporium cladosporioides)

Less

Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
HS Code: 29209010
Hazardous Substances Data: 121263-19-2(Hazardous Substances Data)

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C6303
Product name: Calphostin C from Cladosporium cladosporioides
Purity: ≥90% (HPLC), powder
Packaging: 0.1mg
Price: $436
Updated: 2025/07/31

Sigma-Aldrich

Product number: C6303
Product name: Calphostin C from Cladosporium cladosporioides
Purity: ≥90% (HPLC), powder
Packaging: 1mg
Price: $1386
Updated: 2025/07/31

Sigma-Aldrich

Product number: 208725
Product name: Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem
Purity: Acellpermeable,highlyspecificinhibitorofproteinkinaseC(IC??=50nM)t
Packaging: 50μg
Price: $154
Updated: 2023/01/07

Sigma-Aldrich

Product number: 208725
Product name: Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem
Purity: Acellpermeable,highlyspecificinhibitorofproteinkinaseC(IC??=50nM)t
Packaging: 100μg
Price: $264
Updated: 2023/01/07

Cayman Chemical

Product number: 15383
Product name: Calphostin C
Purity: ≥95%
Packaging: 100μg
Price: $142
Updated: 2024/03/01

Less

CALPHOSTIN C Chemical Properties,Usage,Production

Chemical Properties

Dark red solid

Uses

Calphostin C (CGP049090) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.

Uses

Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.

Uses

Potent inhibitor of protein kinase C

Biological Activity

Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM).

Biochem/physiol Actions

Highly specific inhibitor of protein kinase C (IC50 = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.

storage

+4°C (desiccate)

CALPHOSTIN C Preparation Products And Raw materials

Raw materials

Preparation Products

Less

CALPHOSTIN C Suppliers

Belgium 1 China 87 Europe 1 Germany 2 India 1 Japan 2 Switzerland 3 United Kingdom 6 United States 20 Global 123

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9941
Advantage: 58

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

Shandong Fengtai Biotechnology Co., Ltd.

Tel: 0531-0531-82066716 15662658391
Fax: 0531-82066716
Email: 528732991@qq.com
Country: China
ProdList: 1060
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988941452
Fax: QQ：3283937693
Email: YN_research@163.com
Country: China
ProdList: 3011
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8860
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Aleshan (Guangzhou) Biotechnology Co., Ltd

Tel: 18636736628
Email: Araratbio@163.com
Country: China
ProdList: 3342
Advantage: 58

Shanghai kadel chemical technology co., LTD

Tel: 021-4007787-550 400-7787-550
Email: 2850202386@qq.com
Country: China
ProdList: 10582
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-81124267 17392282731
Fax: 029-88380327
Email: 1073@dideu.com
Country: China
ProdList: 9992
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shandong Yatu Biotechnology Co. LTD

Tel: 0531-55555418 15301096991
Email: 811301959@qq.com
Country: China
ProdList: 1139
Advantage: 58

Auonsi (Shanghai) Biology Technology Co., Ltd.

Tel: 400-1107768 15058188853
Fax: 0571-88150696
Email: 478133536@qq.com
Country: China
ProdList: 8552
Advantage: 58

Hangzhou Bingochem Co., Ltd.

Tel: 0571-8512-5372
Email: sales@bingochem.com
Country: China
ProdList: 21669
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29965
Advantage: 58

Nantong Tianxiang Bioengineering Co., Ltd

Tel: 15152885778 4006716686
Fax: 0513-5666452
Email: 475035221@qq.com
Country: China
ProdList: 1073
Advantage: 58

Hubei Danding Pharmaceutical Technology Co., Ltd

Tel: 17701422019
Email: 1559451077@qq.com
Country: China
ProdList: 8163
Advantage: 58

Shanghai Weiyite Biotechnology Co., Ltd

Tel: 15317051735
Email: zhaojing@wytsci.com
Country: China
ProdList: 9980
Advantage: 58

R&D Systems, Inc

Tel: 18003437475
Fax: 1-612-656-4400
Email: rdname@qq.com
Country: China
ProdList: 6960
Advantage: 58

Adipogen Life Sciences

Tel: 41-6192660-40
Email: info@adipogen.com
Country: China
ProdList: 5293
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Enzo Biochem Inc

Tel: Enzo Biochem Inc. 13797054060
Email: Enzoname@qq.com
Country: China
ProdList: 6174
Advantage: 58

Merck KGaA

Tel: 21-20338288
Email: ordercn@merckgroup.com
Country: China
ProdList: 6394
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., Ltd.,

Tel: 18915873328 18915873328
Email: 296197970@qq.com
Country: China
ProdList: 11051
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

HANGZHOU LEAP CHEM CO., LTD.

Tel: +86-571-87711850
Email: market18@leapchem.com
Country: China
ProdList: 43339
Advantage: 58

HANGZHOU LEAP CHEM CO., LTD.

Tel: +86-571-87711850
Email: market18@leapchem.com
Country: China
ProdList: 24727
Advantage: 58

Shanghai Ruili Spectrum Biotechnology Co., Ltd

Tel: 021-64705760 18027310741
Email: 1060496435@qq.com
Country: China
ProdList: 4566
Advantage: 58

Qingdao Everest Technology & Trade Co., Ltd.

Tel: 13792478491
Country: CHINA
ProdList: 161
Advantage: 58

Guangzhou Tuoshan Biotechnology Co., Ltd.

Tel: 19928332050
Country: CHINA
ProdList: 161
Advantage: 58

Lucheng (Shenzhen) Technology Co., Ltd.

Tel: 13128698830
Country: CHINA
ProdList: 181
Advantage: 58

Shenzhen Zuoke Biotechnology Co., Ltd.

Tel: 13532174601
Country: CHINA
ProdList: 109
Advantage: 58

121263-19-2, CALPHOSTIN CRelated Search:

NS-398 4-Hydroxy-1-naphthaldehyde 2'-HYDROXY-1'-ACETONAPHTHONE 1-ALLYLNAPHTHALENE 9-ETHYLPHENANTHRENE 4-PHENYL-2-BUTYL ACETATE 9-METHYLPHENANTHRENE 1,7-DIMETHYLNAPHTHALENE 2-Vinylnaphthalene ACETIC ACID 3-PHENYL-BUT-3-ENYL ESTER 1,2-DIMETHYLNAPHTHALENE 2-Naphthaleneethanol 2-HYDROXY-1-NAPHTHALDEHYDE Divinylbenzene calphostin B 7-METHYL-2-NAPHTHOL 1-Naphthalenol,6-methyl-(9CI) 1,8-DIMETHYLPHENANTHRENE

CALPHOSTIN C

CALPHOSTIN C FROM CLADOSPORIUMCLADOSPORI OIDES

UCN-1028C

(R)-Calphostin C

1-[(R)-2-(4-Hydroxyphenoxycarbonyloxy)propyl]-2,6,7,11-tetramethoxy-4,9-dihydroxy-12-[(R)-2-(benzoyloxy)propyl]-3,10-dihydroperylene-3,10-dione

4,9-Dihydroxy-12-[(R)-2-(4-hydroxyphenyloxy)carbonyloxypropyl]-2,6,7,11-tetramethoxy-1-[(R)-2-benzoyloxypropyl]perylene-3,10-dione

Calphostin C,98%

Calphostin CUCN-1028C

(1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonicacid4-hydroxyphenylester

Calphostin C(UCN 1028C, PKF 115584)

C,CalphostinCfroMCladosporiuMcladosporioide

CALPHOSTIN C, CLADOSPORIUM CLADOSPORIOIDES

2-[12-[2-(BENZOYLOXY)PROPYL]-3,10-DIHYDRO-4,9-DIHYDROXY-2,6,7,11-TETRAMETHOX Y-3,10-DIOXO-1-PERYLENYL]-1-METHYLETHYL CARBONIC ACID 4-HYDROXYPHENYL ESTER

UCN 1028 C, PKF 115-384

Cladochrome E

PKF 115-584

Calphostin C, 95.0+ % (HPLC)

(1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethyl 4-carbonic

He Ding C Carver

Carbonic acid,(1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethyl4-hydroxyphenyl ester, stereoisomer

Calphostin C DISCONTINUED

2-Diazole

CAS:121263-19-2

Calphostin C, <i>Cladosporium cladosporioides</i>

Calphostin C from <i>Cladosporium cladosporioides</i>

121263-19-2

C44H38O14

Kinase/Phosphatase Biology

Serine/Threonine Kinase Inhibitors

Protein Kinase C (PKC)

BioChemical

Cell Biology

Cell Signaling and Neuroscience