CALPHOSTIN C

ChemicalBook > CAS DataBase List > CALPHOSTIN C

Product Name: CALPHOSTIN C
CAS No.: 121263-19-2
Chemical Name: CALPHOSTIN C
Synonyms: UCN-1028C;2-Diazole;PKF 115-584;CALPHOSTIN C;Cladochrome E;(R)-Calphostin C;Calphostin C,98%;He Ding C Carver;Calphostin CUCN-1028C;UCN 1028 C, PKF 115-384
CBNumber: CB7457711
Molecular Formula: C44H38O14
Formula Weight: 790.76
MOL File: 121263-19-2.mol

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CALPHOSTIN C Property

Boiling point:: 1039.8±65.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMF: 1 mg/mL
form: powder
pka: 7.30±0.20(Predicted)
color: red to brown

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
HS Code: 29209010
Hazardous Substances Data: 121263-19-2(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C6303
Product name: Calphostin C from Cladosporium cladosporioides
Purity: ≥90% (HPLC), powder
Packaging: 0.1mg
Price: $254.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: C6303
Product name: Calphostin C from Cladosporium cladosporioides
Purity: ≥90% (HPLC), powder
Packaging: 1mg
Price: $812
Updated: 2024/03/01

Sigma-Aldrich

Product number: 208725
Product name: Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem
Purity: Acellpermeable,highlyspecificinhibitorofproteinkinaseC(IC??=50nM)t
Packaging: 50μg
Price: $154
Updated: 2023/01/07

Sigma-Aldrich

Product number: 208725
Product name: Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem
Purity: Acellpermeable,highlyspecificinhibitorofproteinkinaseC(IC??=50nM)t
Packaging: 100μg
Price: $264
Updated: 2023/01/07

Alfa Aesar

Product number: J60647
Product name: Calphostin C, 95%
Packaging: 100microg
Price: $238
Updated: 2023/06/20

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CALPHOSTIN C Chemical Properties,Usage,Production

Chemical Properties

Dark red solid

Uses

Calphostin C (CGP049090) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.

Uses

Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.

Uses

Potent inhibitor of protein kinase C

Biological Activity

Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM).

Biochem/physiol Actions

Highly specific inhibitor of protein kinase C (IC50 = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.

storage

+4°C (desiccate)

CALPHOSTIN C Preparation Products And Raw materials

Raw materials

Preparation Products

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CALPHOSTIN C Suppliers

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121263-19-2, CALPHOSTIN CRelated Search:

NS-398 4-Hydroxy-1-naphthaldehyde 2'-HYDROXY-1'-ACETONAPHTHONE 1-ALLYLNAPHTHALENE 9-ETHYLPHENANTHRENE 4-PHENYL-2-BUTYL ACETATE 9-METHYLPHENANTHRENE 1,7-DIMETHYLNAPHTHALENE 2-Vinylnaphthalene ACETIC ACID 3-PHENYL-BUT-3-ENYL ESTER 1,2-DIMETHYLNAPHTHALENE 2-Naphthaleneethanol 2-HYDROXY-1-NAPHTHALDEHYDE Divinylbenzene calphostin B 7-METHYL-2-NAPHTHOL 1-Naphthalenol,6-methyl-(9CI) 1,8-DIMETHYLPHENANTHRENE

CALPHOSTIN C

CALPHOSTIN C FROM CLADOSPORIUMCLADOSPORI OIDES

UCN-1028C

(R)-Calphostin C

1-[(R)-2-(4-Hydroxyphenoxycarbonyloxy)propyl]-2,6,7,11-tetramethoxy-4,9-dihydroxy-12-[(R)-2-(benzoyloxy)propyl]-3,10-dihydroperylene-3,10-dione

4,9-Dihydroxy-12-[(R)-2-(4-hydroxyphenyloxy)carbonyloxypropyl]-2,6,7,11-tetramethoxy-1-[(R)-2-benzoyloxypropyl]perylene-3,10-dione

Calphostin C,98%

Calphostin CUCN-1028C

(1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonicacid4-hydroxyphenylester

Calphostin C(UCN 1028C, PKF 115584)

C,CalphostinCfroMCladosporiuMcladosporioide

CALPHOSTIN C, CLADOSPORIUM CLADOSPORIOIDES

2-[12-[2-(BENZOYLOXY)PROPYL]-3,10-DIHYDRO-4,9-DIHYDROXY-2,6,7,11-TETRAMETHOX Y-3,10-DIOXO-1-PERYLENYL]-1-METHYLETHYL CARBONIC ACID 4-HYDROXYPHENYL ESTER

UCN 1028 C, PKF 115-384

Cladochrome E

PKF 115-584

Calphostin C, 95.0+ % (HPLC)

(1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethyl 4-carbonic

He Ding C Carver

Carbonic acid,(1R)-2-[12-[(2R)-2-(benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethyl4-hydroxyphenyl ester, stereoisomer

Calphostin C DISCONTINUED

2-Diazole

121263-19-2

C44H38O14

Kinase/Phosphatase Biology

Serine/Threonine Kinase Inhibitors

Protein Kinase C (PKC)

BioChemical

Cell Biology

Cell Signaling and Neuroscience