ChemicalBook > CAS DataBase List > NS-398

NS-398

Product Name: NS-398
CAS No.: 123653-11-2
Chemical Name: NS-398
Synonyms: NS NS;NS-398;CS-2231;NS-398 98%;Taisho NS 398;NS-398 (NS 398;NS-398 USP/EP/BP;glycolysis inhibitor;NS-398, 10 mM in DMSO;NS 398, COX-2 inhibitor
CBNumber: CB1754593
Molecular Formula: C13H18N2O5S
Formula Weight: 314.36
MOL File: 123653-11-2.mol

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NS-398 Property

Melting point:: 124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boiling point:: 490.6±55.0 °C(Predicted)
Density: 1.377±0.06 g/cm3(Predicted)
RTECS: PB0473500
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: >5 mg/mL
form: solid
pka: 6.33±0.10(Predicted)
color: off-white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2935.90.9500

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N194
Product name: NS-398
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $281.61
Updated: 2025/07/31

Sigma-Aldrich

Product number: 349254
Product name: NS-398
Purity: A cell-permeable selective inhibitor of COX-2
Packaging: 5mg
Price: $233
Updated: 2025/07/31

TCI Chemical

Product number: N1152
Product name: NS-398
Packaging: 10MG
Price: $102
Updated: 2025/07/31

TCI Chemical

Product number: N1152
Product name: NS-398
Packaging: 50MG
Price: $370
Updated: 2025/07/31

Cayman Chemical

Product number: 70590
Product name: NS-398
Purity: ≥98%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

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NS-398 Chemical Properties,Usage,Production

Description

NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC₅₀ values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively. The IC₅₀ values for ovine COX-1 and -2 are 220 and 0.15 μM, respectively.

Uses

NS-398 is a selective Cox-2 inhibitor neuroprotective agent.

Definition

ChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.

Biological Activity

Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .

storage

Store at RT

References

[1]. futaki n, takahashi s, yokoyama m, et al. ns-398, a new anti-inflammatory agent, selectively inhibits prostaglandin g/h synthase/cyclooxygenase (cox-2) activity in vitro. prostaglandins, 1994, 47(1): 55-59.
[2]. elder dj, halton de, crew te, et al. apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug ns-398. int j cancer, 2000, 86(4): 553-560.
[3]. mack strong ve, mackrell pj, concannon em, et al. ns-398 treatment after trauma modifies nf-kappab activation and improves survival. j surg res, 2001, 98(1): 40-46.

NS-398 Preparation Products And Raw materials

Raw materials

Preparation Products

Glyoxal Acrylamide

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NS-398 Suppliers

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View Lastest Price from NS-398 manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: NS-398 123653-11-2
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

Hebei Yanxi Chemical Co., Ltd.

Product: NS-398 123653-11-2
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-11-28

123653-11-2, NS-398Related Search:

CALPHOSTIN C Trypsin inhibitor Potassium heptadecafluoro-1-octanesulfonate Pentasodium DTPA AG 18 AG 490 TYRPHOSTIN A25 Roscovitine Potassium clavulanate Ancymidol NS-398 3-ISOPROPOXYANILINE 4-NITRO-2-PROPOXY-PHENYLAMINE 4-NITRO METHANESULFONANILIDE 4-nitro-o-phenetidine N-(2-METHOXY-4-NITRO-PHENYL)-METHANESULFONAMIDE NS-398 (N-(2-Cyclohexyloxy-4-nitrophenyl) -Methanesulfonamide) Methanesulfonamide, N-(2-ethoxyphenyl)- (9CI)

CS-2231

NS-398 (NS 398

NS-398 - CAS 123653-11-2 - Calbiochem

NS-398

N-[2-(CYCLOHEXYLOXY)-4-NITROPHENYL]-METHANESULFONAMIDE

NS-398 98%

N-[2-(cyclohexoxy)-4-nitro-phenyl]methanesulfonamide

Taisho NS 398

NS 398; NS398; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANE SULFONAMIDE

NS NS

Methanesulfonamide, N-[2-(cyclohexyloxy)-4-nitrophenyl]-

NS-398 USP/EP/BP

Inhibitor,inhibit,NS-398,NS 398,COX,Cyclooxygenase

mitochondrial complex I inhibitor

mitochondrial complex III inhibitor

glycolysis inhibitor

NS 398, COX-2 inhibitor

NS-398, 10 mM in DMSO

123653-11-2

123652-11-2

Cyclooxygenase (COX) Enzymes

Cyclooxygenase Inhibitors

Enzymes, Inhibitors, and Substrates

Biochemicals and Reagents

Cell Signaling Enzymes

BioChemical

Application Index

Signalling

NF-κB Signaling

Lipid signaling