ROLIPRAM
- Product Name
- ROLIPRAM
- CAS No.
- 61413-54-5
- Chemical Name
- ROLIPRAM
- Synonyms
- 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE;SB 95952;ROLIPRAM;ZK-62711;Roliprame;Rolipram >ROLIPRAM 98+%;(R,S)-Rolipram;Rolipram, >=97%;Rolipram Rolipram
- CBNumber
- CB2703866
- Molecular Formula
- C16H21NO3
- Formula Weight
- 275.34
- MOL File
- 61413-54-5.mol
ROLIPRAM Property
- Melting point:
- 127-133 °C
- Boiling point:
- 418.29°C (rough estimate)
- Density
- 1.0677 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- H2O: 0.2 mg/mL
- form
- solid
- pka
- 16.02±0.40(Predicted)
- color
- white to off-white
- Merck
- 14,8251
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-11
- Safety Statements
- 26-36
- RIDADR
- 3249
- WGK Germany
- 3
- RTECS
- UY5749237
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29337900
- Toxicity
- LD50 oral in mouse: > 300mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- R6520
- Product name
- Rolipram
- Purity
- solid, ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 557330
- Product name
- Rolipram
- Packaging
- 5mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- R0110
- Product name
- Rolipram
- Purity
- >98.0%(HPLC)
- Packaging
- 50mg
- Price
- $198
- Updated
- 2024/03/01
- Product number
- R0110
- Product name
- Rolipram
- Purity
- >98.0%(HPLC)
- Packaging
- 250mg
- Price
- $686
- Updated
- 2024/03/01
- Product number
- J67177
- Product name
- Rolipram, 98%
- Packaging
- 5mg
- Price
- $61.1
- Updated
- 2023/06/20
ROLIPRAM Chemical Properties,Usage,Production
Description
Rolipram (61413-54-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 1 μM. Displays beneficial effects in neurodegenerative diseases. Rolipram also displays anti-inflammatory activity and synergizes with forskolin (cat.# 10-2073). Cell permeable.
Chemical Properties
Yellowish solid
Uses
antipsychotic
Uses
A selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4).
Uses
Pharmacological tool for characterization of phosphodiesterase isoenzymes.
Uses
(±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor.
Definition
ChEBI: Rolipram is a member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor. It has a role as an antidepressant and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.
General Description
A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-κB and NFAT activation in Jurkat and primary T cells.
Biological Activity
Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC 50 = 2.0 μ M). Discriminates between two conformational states of PDE4 isoenzymes. See separate isomers ((R)-(-)-Rolipram and (S)-(+)-Rolipram).
Biochem/physiol Actions
Cell permeable: yes
storage
Room temperature
References
1) Reeves et al. (1987), The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase; Biochem. J., 241 535 2) Nishi et al. (2008), Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum; J. Neurosci., 28 10460 3) Christiansen et al. (2011), Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP; Neurochem. Int., 59 837
ROLIPRAM Preparation Products And Raw materials
Raw materials
Preparation Products
ROLIPRAM Suppliers
- Tel
- 13611612777 13611612777
- 1020205779@qq.com
- Country
- China
- ProdList
- 935
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24539
- Advantage
- 81
- Tel
- 4401179829988
- Fax
- 4402030 700 369
- customerservice@ascentscientific.co.uk
- Country
- United Kingdom
- ProdList
- 279
- Advantage
- 60
- Tel
- 1-(800)-881-8210
- Fax
- 615-250-9817
- inquiries@lgmpharma.com
- Country
- United States
- ProdList
- 2127
- Advantage
- 70
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15421
- Advantage
- 60
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12990
- Advantage
- 57
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4647
- Advantage
- 58
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4941
- Advantage
- 60
View Lastest Price from ROLIPRAM manufacturers
- Product
- rolipram 61413-54-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- ROLIPRAM 61413-54-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-02-14