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ROLIPRAM

Product Name
ROLIPRAM
CAS No.
61413-54-5
Chemical Name
ROLIPRAM
Synonyms
4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE;SB 95952;ROLIPRAM;ZK-62711;Roliprame;Rolipram >ROLIPRAM 98+%;(R,S)-Rolipram;Rolipram, >=97%;Rolipram Rolipram
CBNumber
CB2703866
Molecular Formula
C16H21NO3
Formula Weight
275.34
MOL File
61413-54-5.mol
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ROLIPRAM Property

Melting point:
127-133 °C
Boiling point:
418.29°C (rough estimate)
Density 
1.0677 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
H2O: 0.2 mg/mL
form 
solid
pka
16.02±0.40(Predicted)
color 
white to off-white
Merck 
14,8251
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-11
Safety Statements 
26-36
RIDADR 
3249
WGK Germany 
3
RTECS 
UY5749237
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29337900
Toxicity
LD50 oral in mouse: > 300mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R6520
Product name
Rolipram
Purity
solid, ≥98% (HPLC)
Packaging
10mg
Price
$176
Updated
2024/03/01
Sigma-Aldrich
Product number
557330
Product name
Rolipram
Packaging
5mg
Price
$230
Updated
2024/03/01
TCI Chemical
Product number
R0110
Product name
Rolipram
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$198
Updated
2024/03/01
TCI Chemical
Product number
R0110
Product name
Rolipram
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$686
Updated
2024/03/01
Alfa Aesar
Product number
J67177
Product name
Rolipram, 98%
Packaging
5mg
Price
$61.1
Updated
2023/06/20
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ROLIPRAM Chemical Properties,Usage,Production

Description

Rolipram (61413-54-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 1 μM. Displays beneficial effects in neurodegenerative diseases. Rolipram also displays anti-inflammatory activity and synergizes with forskolin (cat.# 10-2073). Cell permeable.

Chemical Properties

Yellowish solid

Uses

antipsychotic

Uses

A selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4).

Uses

Pharmacological tool for characterization of phosphodiesterase isoenzymes.

Uses

(±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor.

Definition

ChEBI: Rolipram is a member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor. It has a role as an antidepressant and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.

General Description

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-κB and NFAT activation in Jurkat and primary T cells.

Biological Activity

Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC 50 = 2.0 μ M). Discriminates between two conformational states of PDE4 isoenzymes. See separate isomers ((R)-(-)-Rolipram and (S)-(+)-Rolipram).

Biochem/physiol Actions

Cell permeable: yes

storage

Room temperature

References

1) Reeves et al. (1987), The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase; Biochem. J., 241 535 2) Nishi et al. (2008), Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum; J. Neurosci., 28 10460 3) Christiansen et al. (2011), Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP; Neurochem. Int., 59 837

ROLIPRAM Preparation Products And Raw materials

Raw materials

Preparation Products

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ROLIPRAM Suppliers

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View Lastest Price from ROLIPRAM manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
rolipram 61413-54-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Career Henan Chemical Co
Product
ROLIPRAM 61413-54-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kgs
Release date
2020-02-14

61413-54-5, ROLIPRAMRelated Search:

Rolapitant Donepezil PP242 Milrinone WORTMANNIN Vinpocetine Cilostazol Forskolin 2-Pyrrolidinone S- (+)-Rolipram ROLIPRAM (R)-(-)-ROLIPRAM,(S)-(+)-ROLIPRAM,Rolipram (R)-(-)- [METHYL-3H]ROLIPRAM ROLIPRAM [6-3H] S-Desmethyl-Rolipram (+)-Desmethyl-Rolipram,R-Desmethyl-Rolipram (R,S)-Desmethyl-Rolipram (R)-(-)-ROLIPRAM, >98%

  • ROLIPRAM 98+%
  • Roliprame
  • 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
  • SB 95952
  • 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK62711
  • 4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]-2-PYRROLIDINONE
  • 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE
  • (R,S)-Rolipram
  • ZK-62711, SB95952, ME-3167
  • Rolipram, >=97%
  • SB95952;ZK62711;(R;S)-ROLIPRAM;SB 95952;ZK 62711;SB-95952;ZK-62711
  • Rolipram - CAS 61413-54-5 - Calbiochem
  • ROLIPRAM
  • PYRROLIDIN-2-ONE, 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)- (+/-)
  • ZK-62711
  • 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinon
  • Rolipram, 98%, a PDE4 inhibitor
  • Rolipram &gt
  • Rolipram Rolipram
  • ROLIPRAM USP/EP/BP
  • Rolipram - CAS 61413-54-5
  • Rolipram (ME 3167
  • RolipramQ: What is Rolipram Q: What is the CAS Number of Rolipram Q: What is the storage condition of Rolipram Q: What are the applications of Rolipram
  • Rolipram (ZK-62711)
  • 61413-54-5
  • C16H21NO3
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Cyclic Nucleotide Metabolism
  • G Proteins and Cyclic Nucleotides
  • Phosphodiesterase Inhibitors
  • Inhibitor
  • DIPIPERON
  • Inhibitors
  • Antineoplastic
  • Cyclic Nucleotide related
  • Signalling