(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE

Product Name: (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
CAS No.: 85416-75-7
Chemical Name: (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
Synonyms: CS-1181;(?)-Rolipram;(-)-Rolipram;(R)-(-)-ROLIPRAM;(S)-(+)-ROLIPRAM;Rolipram (R)-(-)-;(R)-(-)-Rolipram;(R)-ROLIPRAM;(-)-ROLIPRAM;(R)-(-)-Rolipram, Selective PDE4 inhibitor;4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone
CBNumber: CB2264846
Molecular Formula: C16H21NO3
Formula Weight: 275.34
MOL File: 85416-75-7.mol

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(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Property

Melting point:: 132.0 to 136.0 °C
Boiling point:: 472.7±45.0 °C(Predicted)
Density: 1.155±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 16.02±0.40(Predicted)
form: White to off-white solid.
color: Off-White

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Safety

HS Code: 2933.79.8500
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: R0182
Product name: (R)-(-)-Rolipram
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $158
Updated: 2024/03/01

TCI Chemical

Product number: R0182
Product name: (R)-(-)-Rolipram
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $549
Updated: 2024/03/01

Tocris

Product number: 1349
Product name: (R)-(-)-Rolipram
Purity: ≥98%(HPLC)
Packaging: 10
Price: $212
Updated: 2021/12/16

Tocris

Product number: 1349
Product name: (R)-(-)-Rolipram
Purity: ≥98%(HPLC)
Packaging: 50
Price: $876
Updated: 2021/12/16

TRC

Product number: R640043
Product name: R-(-)-Rolipram
Packaging: 5mg
Price: $140
Updated: 2021/12/16

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(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Chemical Properties,Usage,Production

Uses

R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.

Definition

ChEBI: (-)-rolipram is the (R)-enantiomer of rolipram. It is an enantiomer of a (+)-rolipram.

Biological Activity

More active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ); 2-10-fold more potent than the S-(+) enantiomer ((4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one ). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

storage

Room temperature

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Suppliers

China 43 Germany 6 India 3 Japan 1 The Netherlands 1 United Kingdom 9 United States 30 Global 93

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
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Capot Chemical Co., Ltd

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Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18207
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Ascent Scientific

Tel: 4401179829988
Fax: 4402030 700 369
Email: customerservice@ascentscientific.co.uk
Country: United Kingdom
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Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9810
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HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD

Tel: 571-89189769 15168342188
Fax: 0571-86205065
Country: China
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
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TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
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MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

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View Lastest Price from (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE manufacturers

Career Henan Chemica Co

Product: (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE 85416-75-7
Price: US $1.00/g
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20ton
Release date: 2020-10-28

85416-75-7, (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONERelated Search:

ZARDAVERINE RO 20-1724 S- (+)-Rolipram 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE ETAZOLATE BRL 50481 Vinpocetine ZAPRINAST Cilostazol CILOSTAMIDE Pentoxifylline AG 1295 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE EHNA HYDROCHLORIDE 4-(4'-Methoxyphenyl)-2-pyrrolidinone 4-(3'-Methoxyphenyl)-2-pyrrolidinone (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE 1-(4-bromobenzyl)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

(4R)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE

(S)-(+)-ROLIPRAM

(R)-(-)-ROLIPRAM

(4R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one

Rolipram (R)-(-)-

(4R)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

(<i>R</i>)-(-)-Rolipram

4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone

(R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

CS-1181

(R)-ROLIPRAM;(-)-ROLIPRAM

2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)-

(?)-Rolipram

(-)-Rolipram

Inhibitor,inhibit,Phosphodiesterase (PDE),(R)()Rolipram,(R) ( ) Rolipram

(R)-(-)-Rolipram, Selective PDE4 inhibitor

85416-75-7

Signalling

Cyclic Nucleotide related