ChemicalBook > CAS DataBase List > AG 1295

AG 1295

Product Name: AG 1295
CAS No.: 71897-07-9
Chemical Name: AG 1295
Synonyms: AG 1295;NSC 380341;AG 1295 USP/EP/BP;TYRPHOSTIN AG 1295;TYROPHOSTIN AG1295;AG-1295 (NSC 380341;AG 1295, 10 mM in DMSO;TYRPHOSTIN AG 1295, 99+%;AG 1295 PLATELET-DERIVED GROW;6,7-DIMETHYL-2-PHENYLQUINOXALINE
CBNumber: CB5683675
Molecular Formula: C16H14N2
Formula Weight: 234.3
MOL File: 71897-07-9.mol

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AG 1295 Property

Melting point:: 121 °C
Boiling point:: 398.3±37.0 °C(Predicted)
Density: 1.127±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: White solid
pka: 1.29±0.30(Predicted)
color: Yellow

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 658550
Product name: AG 1295
Packaging: 5mg
Price: $139
Updated: 2025/07/31

Sigma-Aldrich

Product number: R365327
Product name: 6,7-DIMETHYL-2-PHENYL-QUINOXALINE
Purity: AldrichCPR
Packaging: 25MG
Price: $28.6
Updated: 2023/06/20

Cayman Chemical

Product number: 14529
Product name: AG 1295
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 14529
Product name: AG 1295
Purity: ≥98%
Packaging: 5mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 14529
Product name: AG 1295
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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AG 1295 Chemical Properties,Usage,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1295 is a quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGF receptor kinase in vitro and in Swiss 3T3 cells (IC₅₀s range from 0.3-1 μM). It inhibits PDGF-stimulated DNA synthesis with an IC₅₀ value of 2.5 μM without affecting activity of the EGF receptor.

Uses

AG-1295 is a protein tyrosine kinase inhibitor. Antiproliferative agent used in the treatment of atherosclerosis, pulmonary fibrosis, and gliomas.

Definition

ChEBI: 6,7-dimethyl-2-phenylquinoxaline is a quinoxaline derivative. It has a role as a geroprotector.

in vitro

the previous study investigated the effect of pdgf receptor-beta (pdgfr-β) inhibition by ag-1295 on the osteogenic differentiation of the mouse pre-osteoblastic cell line mc3t3-e1. results showed that ag-1295 could significantly increase the alkaline phosphatase (alp) activity and enhance the formation of mineralized nodules dose-dependently. moreover, the treatment with ag-1295 led to the up-regulated mrna expression of the osteogenic marker genes collagen type i, runt-related transcription factor 2, osterix, tissue-nonspecific alkaline phosphatase, as well as osteocalcin. consistent with its effect on osteoblast differentiation, ag-1295 was also able to significantly suppress the phosphorylation of erk1/2 in mc3t3-e1 cells [1].

in vivo

a previous animal study was designed to evaluated the possible effects of ag1295 on the development of interstitial fibrosis in rats with unilateral ureteral obstruction, monitored by ed-a+ fibronectin expression, the number of macrophages. results showed that the i.p.treatment with ag1295 at 12 mg/kg could significantly reduce interstitial fibrosis as verified by a smaller sirius-red stained area and also by a reduced number of macrophages, and by the ed-a+ fibronectin deposition and the number of cells positive for α-smooth muscle actin [2].

IC 50

0.3-1 μm for pdgf receptor kinase in vitro and in swiss 3t3 cells

References

[1] zhang yy, cui yz, luan j, zhou xy, zhang gl, han jx. platelet-derived growth factor receptor kinase inhibitor ag-1295 promotes osteoblast differentiation in mc3t3-e1 cells via the erk pathway. biosci trends. 2012 jun;6(3):130-5.
[2] ludewig d, kosmehl h, sommer m, bhmer fd, stein g. pdgf receptor kinase blocker ag1295 attenuates interstitial fibrosis in rat kidney after unilateral obstruction. cell tissue res. 2000 jan;299(1):97-103.

AG 1295 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AG 1295 manufacturers

Career Henan Chemical Co

Product: AG 1295 71897-07-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98-100%
Supply Ability: 1000kg
Release date: 2018-08-20

71897-07-9, AG 1295Related Search:

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6,7-DIMETHYL-2-PHENYLQUINOXALINE

AG 1295

TYROPHOSTIN AG1295

TYRPHOSTIN AG 1295

AG 1295 PLATELET-DERIVED GROW

TYRPHOSTIN AG 1295, 99+%

Quinoxaline, 6,7-dimethyl-2-phenyl-

AG-1295 (NSC 380341

NSC 380341

AG 1295 USP/EP/BP

Platelet-derived growth factor receptor,RTK,AG 1295,inhibit,PDGF-receptor,AG-1295,autophosphorylation,Inhibitor,AG1295,PDGFR

AG 1295, 10 mM in DMSO

71897-07-9

70897-07-9

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Kinase/Phosphatase Biology

Receptor Tyrosine Kinase Inhibitors

Platelet Derived Growth Factor Receptor (PDGFR)