AG 213

Product Name: AG 213
CAS No.: 122520-86-9
Chemical Name: AG 213
Synonyms: AG 213;RG-50864;TYRPHOSTIN 47;TYRPHOSTIN A47;AG 213 USP/EP/BP;TYRPHOSTIN AG 213;TYRPHOSTIN A47 99+%;TYRPHOSTIN RG 50864;AG 213 (Tyrphostin AG 213);ZGHQGWOETPXKLY-XVNBXDOJSA-N
CBNumber: CB5152917
Molecular Formula: C10H8N2O2S
Formula Weight: 220.25
MOL File: 122520-86-9.mol

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AG 213 Property

Melting point:: 213 °C
Boiling point:: 474.5±55.0 °C(Predicted)
Density: 1.512±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 50 mg/mL, clear, orange
form: Orange solid.
pka: 8.82±0.10(Predicted)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J67345
Product name: Tyrphostin AG-213
Purity: 97%
Packaging: 5mg
Price: $104
Updated: 2021/12/16

Alfa Aesar

Product number: J67345
Product name: Tyrphostin AG-213
Purity: 97%
Packaging: 10mg
Price: $151
Updated: 2021/12/16

Cayman Chemical

Product number: 10010314
Product name: AG-213
Purity: ≥97%
Packaging: 5mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 10010314
Product name: AG-213
Purity: ≥97%
Packaging: 10mg
Price: $107
Updated: 2024/03/01

Alfa Aesar

Product number: J67345
Product name: Tyrphostin AG-213
Purity: 97%
Packaging: 25mg
Price: $356
Updated: 2021/12/16

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AG 213 Chemical Properties,Usage,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-213 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC₅₀ value of 2.4 μM in the human epidermoid carcinoma cell line A431.

Uses

Tyrphostin 47 is a potent inhibitor of EGFR kinase activity.

Definition

ChEBI: 3-amino-2-[(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-mercapto-2-propenenitrile is a member of quinomethanes.

Biological Activity

Epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC 50 values are 2.4 and 3 μ M respectively). Stimulates microtubule polymerization and promotes neurite outgrowth > 17-fold over basal conditions in vitro . Also weakly inhibits protein kinase C (IC 50 = 60 μ M).

References

[1] romer l h, mclean n, turner c e, et al. tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells[j]. molecular biology of the cell, 1994, 5(3): 349-361.
[2] gazit a, yaish p, gilon c, et al. tyrphostins i: synthesis and biological activity of protein tyrosine kinase inhibitors[j]. journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[3] levitzki a, gazit a. tyrosine kinase inhibition: an approach to drug development[j]. science, 1995, 267(5205): 1782.
[4] herbst r s. review of epidermal growth factor receptor biology[j]. international journal of radiation oncology biology physics, 2004, 59(2): s21-s26.

AG 213 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 213 Suppliers

China 28 Germany 3 India 1 Switzerland 2 United Kingdom 3 United States 10 Global 47

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 22883
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44808
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9267
Advantage: 58

122520-86-9, AG 213Related Search:

AG 18 TYRPHOSTIN A9 TYRPHOSTIN A25 Canertinib TYRPHOSTIN A51 AG 1295 AG 490 AG 1478 NS-398 BIS-TYRPHOSTIN AG 825 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) TYRPHOSTIN A63 TYRPHOSTIN A1 AG 99 TYRPHOSTIN AG 1288 AG 213,TYRPHOSTIN AG 213 (E)-N-(3''-PHENYLPROPYL-ALPHA-CYANO-3'-5'-DIISOPROPYL-4'-HYDROXYCINNAMAMIDE)

ALPHA-CYANO-3,4-DIHYDROXYTHIOCINNAMAMIDE

ALPHA-CYANO-(3,4-DIHYDROXY)THIOCINNAMIDE

AG 213

3,4-DIHYDROXY-ALPHA-CYANOTHIOCINNAMAMIDE

(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-2-PROPENTHIOAMIDE

TYRPHOSTIN A47 99+%

AG 213 (Tyrphostin AG 213)

ZGHQGWOETPXKLY-XVNBXDOJSA-N

TYRPHOSTIN 47

TYRPHOSTIN A47

TYRPHOSTIN AG 213

TYRPHOSTIN RG 50864

RG-50864

3-amino-2-[(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile

AG 213 USP/EP/BP

2-Propenethioamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-

122520-86-9

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Biochemicals and Reagents

Substrate Analogs

Receptor Tyrosine Kinase Inhibitors

Epidermal Growth Factor Receptor (EGFR)

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Type

Enzyme Inhibitors

Kinase/Phosphatase Biology

Intracellular Signaling

Protein Kinase