2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)

Product Name: 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)
CAS No.: 122520-79-0
Chemical Name: 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)
Synonyms: A -30;Tyrphostin AG30(AG30);AG 30 (Tyrphostin AG30);Tyrphostin AG30, 10 mM in DMSO;(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoicaci;(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid;2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-;2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI);2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) USP/EP/BP;HER1,ErbB-1,Inhibitor,EGFR,Tyrphostin AG30,Epidermal growth factor receptor,Tyrphostin AG 30,AG30,AG-30,AG 30,Tyrphostin AG-30,inhibit
CBNumber: CB21088483
Molecular Formula: C10H7NO4
Formula Weight: 205.17
MOL File: 122520-79-0.mol

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2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Property

Melting point:: 240 °C
Boiling point:: 465.6±45.0 °C(Predicted)
Density: 1.559±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: 125 mg/mL (609.25 mM)
pka: 0.81±0.10(Predicted)
form: Yellow solid.
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0066283
Product name: TyrphostinAG30
Purity: 98.60%
Packaging: 2mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0066283
Product name: TyrphostinAG30
Purity: 98.60%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0066283
Product name: TyrphostinAG30
Purity: 98.60%
Packaging: 10mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0066283
Product name: TyrphostinAG30
Purity: 98.60%
Packaging: 50mg
Price: $390
Updated: 2021/12/16

ChemScene

Product number: CS-0066283
Product name: TyrphostinAG30
Purity: 98.60%
Packaging: 100mg
Price: $650
Updated: 2021/12/16

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2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Chemical Properties,Usage,Production

Uses

Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts[1][2].

References

[1] Volberg T, et al. The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions. EMBO J. 1992 May;11(5):1733-42. DOI:10.1002/j.1460-2075.1992.tb05225.x
[2] Wessely O, et al. Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation. Cell Growth Differ. 1997 May;8(5):481-93. PMID:9149900
[3] Banerjee S, et al. Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-alpha-positive breast tumor cells through multiple molecular cross-talks. Mol Cancer Res. 2005 Mar;3(3):151-62. DOI:10.1158/1541-7786.MCR-04-0130

2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Suppliers

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122520-79-0, 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)Related Search:

AG 99 TYRPHOSTIN AG 126 TYRPHOSTIN AG 835 AG 18 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol AG 213 TYRPHOSTIN A51 AG 1295 AG 1478

2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)

(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid

Tyrphostin AG30(AG30)

2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-

(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoicaci

2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) USP/EP/BP

AG 30 (Tyrphostin AG30)

HER1,ErbB-1,Inhibitor,EGFR,Tyrphostin AG30,Epidermal growth factor receptor,Tyrphostin AG 30,AG30,AG-30,AG 30,Tyrphostin AG-30,inhibit

A -30

Tyrphostin AG30, 10 mM in DMSO

122520-79-0

ALCOHOL