ChemicalBook > CAS DataBase List > 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)

2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)

Product Name
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)
CAS No.
122520-79-0
Chemical Name
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)
Synonyms
A -30;Tyrphostin AG30(AG30);AG 30 (Tyrphostin AG30);Tyrphostin AG30, 10 mM in DMSO;(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoicaci;(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid;2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-;2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI);2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) USP/EP/BP;HER1,ErbB-1,Inhibitor,EGFR,Tyrphostin AG30,Epidermal growth factor receptor,Tyrphostin AG 30,AG30,AG-30,AG 30,Tyrphostin AG-30,inhibit
CBNumber
CB21088483
Molecular Formula
C10H7NO4
Formula Weight
205.17
MOL File
122520-79-0.mol
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2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Property

Melting point:
240 °C
Boiling point:
465.6±45.0 °C(Predicted)
Density 
1.559±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: 125 mg/mL (609.25 mM)
pka
0.81±0.10(Predicted)
form 
Yellow solid.
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0066283
Product name
TyrphostinAG30
Purity
98.60%
Packaging
2mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-0066283
Product name
TyrphostinAG30
Purity
98.60%
Packaging
5mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-0066283
Product name
TyrphostinAG30
Purity
98.60%
Packaging
10mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-0066283
Product name
TyrphostinAG30
Purity
98.60%
Packaging
50mg
Price
$390
Updated
2021/12/16
ChemScene
Product number
CS-0066283
Product name
TyrphostinAG30
Purity
98.60%
Packaging
100mg
Price
$650
Updated
2021/12/16
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2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Chemical Properties,Usage,Production

Uses

Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts[1][2].

References

[1] Volberg T, et al. The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions. EMBO J. 1992 May;11(5):1733-42. DOI:10.1002/j.1460-2075.1992.tb05225.x
[2] Wessely O, et al. Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation. Cell Growth Differ. 1997 May;8(5):481-93. PMID:9149900
[3] Banerjee S, et al. Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-alpha-positive breast tumor cells through multiple molecular cross-talks. Mol Cancer Res. 2005 Mar;3(3):151-62. DOI:10.1158/1541-7786.MCR-04-0130

2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Suppliers

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122520-79-0, 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)Related Search:

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  • 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)
  • (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid
  • Tyrphostin AG30(AG30)
  • 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-
  • (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoicaci
  • 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) USP/EP/BP
  • AG 30 (Tyrphostin AG30)
  • HER1,ErbB-1,Inhibitor,EGFR,Tyrphostin AG30,Epidermal growth factor receptor,Tyrphostin AG 30,AG30,AG-30,AG 30,Tyrphostin AG-30,inhibit
  • A -30
  • Tyrphostin AG30, 10 mM in DMSO
  • 122520-79-0
  • ALCOHOL