2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)
- Product Name
- 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)
- CAS No.
- 122520-79-0
- Chemical Name
- 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)
- Synonyms
- A -30;Tyrphostin AG30(AG30);AG 30 (Tyrphostin AG30);Tyrphostin AG30, 10 mM in DMSO;(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoicaci;(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid;2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-;2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI);2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) USP/EP/BP;HER1,ErbB-1,Inhibitor,EGFR,Tyrphostin AG30,Epidermal growth factor receptor,Tyrphostin AG 30,AG30,AG-30,AG 30,Tyrphostin AG-30,inhibit
- CBNumber
- CB21088483
- Molecular Formula
- C10H7NO4
- Formula Weight
- 205.17
- MOL File
- 122520-79-0.mol
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Property
- Melting point:
- 240 °C
- Boiling point:
- 465.6±45.0 °C(Predicted)
- Density
- 1.559±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: 125 mg/mL (609.25 mM)
- pka
- 0.81±0.10(Predicted)
- form
- Yellow solid.
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0066283
- Product name
- TyrphostinAG30
- Purity
- 98.60%
- Packaging
- 2mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-0066283
- Product name
- TyrphostinAG30
- Purity
- 98.60%
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-0066283
- Product name
- TyrphostinAG30
- Purity
- 98.60%
- Packaging
- 10mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0066283
- Product name
- TyrphostinAG30
- Purity
- 98.60%
- Packaging
- 50mg
- Price
- $390
- Updated
- 2021/12/16
- Product number
- CS-0066283
- Product name
- TyrphostinAG30
- Purity
- 98.60%
- Packaging
- 100mg
- Price
- $650
- Updated
- 2021/12/16
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Chemical Properties,Usage,Production
Uses
Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts[1][2].
References
[1] Volberg T, et al. The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions. EMBO J. 1992 May;11(5):1733-42. DOI:10.1002/j.1460-2075.1992.tb05225.x
[2] Wessely O, et al. Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation. Cell Growth Differ. 1997 May;8(5):481-93. PMID:9149900
[3] Banerjee S, et al. Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-alpha-positive breast tumor cells through multiple molecular cross-talks. Mol Cancer Res. 2005 Mar;3(3):151-62. DOI:10.1158/1541-7786.MCR-04-0130
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) Suppliers
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