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AG 99

Product Name
AG 99
CAS No.
122520-85-8
Chemical Name
AG 99
Synonyms
AG 99;(E)-AG 99;TYRPHOSTIN 46;TYRPHOSTIN A46;TYRPHOSTIN B40;AG 99 USP/EP/BP;TYRPHOSTIN AG 99;(E)-AG 99 (AG99);(E)-Tyrphostin 46;TYRPHOSTIN A46 99%
CBNumber
CB5738937
Molecular Formula
C10H8N2O3
Formula Weight
204.18
MOL File
122520-85-8.mol
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AG 99 Property

Melting point:
247 °C
Boiling point:
544.4±50.0 °C(Predicted)
Density 
1.482±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in DMSO
form 
Brown solid.
pka
8.81±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10010313
Product name
AG-99
Purity
≥98%
Packaging
5mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
10010313
Product name
AG-99
Purity
≥98%
Packaging
10mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
10010313
Product name
AG-99
Purity
≥98%
Packaging
25mg
Price
$150
Updated
2024/03/01
Cayman Chemical
Product number
10010313
Product name
AG-99
Purity
≥98%
Packaging
50mg
Price
$264
Updated
2024/03/01
TRC
Product number
A427035
Product name
AG99
Packaging
5mg
Price
$305
Updated
2021/12/16
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AG 99 Chemical Properties,Usage,Production

Uses

Tyrphostin AG 99 is a potent, cell-permeable and reversible inhibitor of EGFR and EGF-dependent cell proliferation.

Biological Activity

Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 10 μ M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145 met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro .

References

[1]. gazit a, osherov n, gilon c, et al. tyrphostins. 6. dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of egf receptor tyrosine kinase in vitro. j med chem, 1996, 39(25): 4905-4911.
[2]. yamamoto n, mammadova g, song rx, et al. tyrosine phosphorylation of p145met mediated by egfr and src is required for serum-independent survival of human bladder carcinoma cells. j cell sci, 2006, 119(pt 22): 4623-4633.

AG 99 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 99 Suppliers

Chengdu Kamel Pharmaceutical Co., Ltd
Tel
028-67136579 15828051124
Email
sales@kamelpharm.com
Country
China
ProdList
1872
Advantage
55
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4420
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
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View Lastest Price from AG 99 manufacturers

Career Henan Chemical Co
Product
AG 99 122520-85-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

122520-85-8, AG 99Related Search:


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