AG 99
- Product Name
- AG 99
- CAS No.
- 122520-85-8
- Chemical Name
- AG 99
- Synonyms
- AG 99;(E)-AG 99;TYRPHOSTIN 46;TYRPHOSTIN A46;TYRPHOSTIN B40;AG 99 USP/EP/BP;TYRPHOSTIN AG 99;(E)-AG 99 (AG99);(E)-Tyrphostin 46;TYRPHOSTIN A46 99%
- CBNumber
- CB5738937
- Molecular Formula
- C10H8N2O3
- Formula Weight
- 204.18
- MOL File
- 122520-85-8.mol
AG 99 Property
- Melting point:
- 247 °C
- Boiling point:
- 544.4±50.0 °C(Predicted)
- Density
- 1.482±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in DMSO
- form
- Brown solid.
- pka
- 8.81±0.10(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 10010313
- Product name
- AG-99
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 10010313
- Product name
- AG-99
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $64
- Updated
- 2024/03/01
- Product number
- 10010313
- Product name
- AG-99
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $150
- Updated
- 2024/03/01
- Product number
- 10010313
- Product name
- AG-99
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $264
- Updated
- 2024/03/01
- Product number
- A427035
- Product name
- AG99
- Packaging
- 5mg
- Price
- $305
- Updated
- 2021/12/16
AG 99 Chemical Properties,Usage,Production
Uses
Tyrphostin AG 99 is a potent, cell-permeable and reversible inhibitor of EGFR and EGF-dependent cell proliferation.
Biological Activity
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 10 μ M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145 met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro .
References
[1]. gazit a, osherov n, gilon c, et al. tyrphostins. 6. dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of egf receptor tyrosine kinase in vitro. j med chem, 1996, 39(25): 4905-4911.
[2]. yamamoto n, mammadova g, song rx, et al. tyrosine phosphorylation of p145met mediated by egfr and src is required for serum-independent survival of human bladder carcinoma cells. j cell sci, 2006, 119(pt 22): 4623-4633.
AG 99 Preparation Products And Raw materials
Raw materials
Preparation Products
AG 99 Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from AG 99 manufacturers
- Product
- AG 99 122520-85-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26