ChemicalBook > CAS DataBase List > AG 99

AG 99

Product Name
AG 99
CAS No.
122520-85-8
Chemical Name
AG 99
Synonyms
AG 99;(E)-AG 99;TYRPHOSTIN 46;TYRPHOSTIN A46;TYRPHOSTIN B40;AG 99 USP/EP/BP;TYRPHOSTIN AG 99;(E)-AG 99 (AG99);(E)-Tyrphostin 46;TYRPHOSTIN A46 99%
CBNumber
CB5738937
Molecular Formula
C10H8N2O3
Formula Weight
204.18
MOL File
122520-85-8.mol
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AG 99 Property

Melting point:
247 °C
Boiling point:
544.4±50.0 °C(Predicted)
Density 
1.482±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in DMSO
form 
Brown solid.
pka
8.81±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10010313
Product name
AG-99
Purity
≥98%
Packaging
5mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
10010313
Product name
AG-99
Purity
≥98%
Packaging
10mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
10010313
Product name
AG-99
Purity
≥98%
Packaging
25mg
Price
$150
Updated
2024/03/01
Cayman Chemical
Product number
10010313
Product name
AG-99
Purity
≥98%
Packaging
50mg
Price
$264
Updated
2024/03/01
TRC
Product number
A427035
Product name
AG99
Packaging
5mg
Price
$305
Updated
2021/12/16
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AG 99 Chemical Properties,Usage,Production

Uses

Tyrphostin AG 99 is a potent, cell-permeable and reversible inhibitor of EGFR and EGF-dependent cell proliferation.

Biological Activity

Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 10 μ M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145 met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro .

References

[1]. gazit a, osherov n, gilon c, et al. tyrphostins. 6. dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of egf receptor tyrosine kinase in vitro. j med chem, 1996, 39(25): 4905-4911.
[2]. yamamoto n, mammadova g, song rx, et al. tyrosine phosphorylation of p145met mediated by egfr and src is required for serum-independent survival of human bladder carcinoma cells. j cell sci, 2006, 119(pt 22): 4623-4633.

AG 99 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 99 Suppliers

China 54 Europe 2 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 3 United States 14 USA 1 Global 78
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View Lastest Price from AG 99 manufacturers

Career Henan Chemical Co
Product
AG 99 122520-85-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

122520-85-8, AG 99Related Search:

TYRPHOSTIN AG 126 TYRPHOSTIN AG 835 AG 18 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol 220127-57-1 AG 99 NS-398 AG 213

  • TYRPHOSTIN AG 99
  • TYRPHOSTIN B40
  • TYRPHOSTIN 46
  • TYRPHOSTIN A46
  • 3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE
  • ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMIDE
  • AG 99
  • (E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide
  • (E)-2-Cyano-3-(3,4-dihydroxyphenyl)propenamide
  • (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-2-PROPENAMIDE
  • TYRPHOSTIN A46 99%
  • 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)
  • (E)-AG 99
  • (E)-Tyrphostin 46
  • (E)-Tyrphostin AG 99
  • 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-
  • 2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
  • AG 99 USP/EP/BP
  • (E)-AG 99 (AG99)
  • inhibit,Inhibitor,(E) AG 99,Epidermal growth factor receptor,HER1,ErbB-1,EGFR,(E)AG 99,(E)-AG 99
  • 122520-85-8
  • ALCOHOL
  • Intracellular Signaling