ChemicalBook > CAS DataBase List > AG 99

AG 99

Product Name
AG 99
CAS No.
122520-85-8
Chemical Name
AG 99
Synonyms
AG 99;(E)-AG 99;TYRPHOSTIN 46;TYRPHOSTIN A46;TYRPHOSTIN B40;AG 99 USP/EP/BP;TYRPHOSTIN AG 99;(E)-AG 99 (AG99);(E)-Tyrphostin 46;TYRPHOSTIN A46 99%
CBNumber
CB5738937
Molecular Formula
C10H8N2O3
Formula Weight
204.18
MOL File
122520-85-8.mol
More
Less

AG 99 Property

Melting point:
247 °C
Boiling point:
544.4±50.0 °C(Predicted)
Density 
1.482±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in DMSO
form 
Brown solid.
pka
8.81±0.10(Predicted)
color 
Light yellow to yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
10010313
Product name
AG-99
Purity
≥98%
Packaging
5mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
10010313
Product name
AG-99
Purity
≥98%
Packaging
10mg
Price
$64
Updated
2024/03/01
Cayman Chemical
Product number
10010313
Product name
AG-99
Purity
≥98%
Packaging
25mg
Price
$150
Updated
2024/03/01
Cayman Chemical
Product number
10010313
Product name
AG-99
Purity
≥98%
Packaging
50mg
Price
$264
Updated
2024/03/01
TRC
Product number
A427035
Product name
AG99
Packaging
5mg
Price
$305
Updated
2021/12/16
More
Less

AG 99 Chemical Properties,Usage,Production

Uses

Tyrphostin AG 99 is a potent, cell-permeable and reversible inhibitor of EGFR and EGF-dependent cell proliferation.

Biological Activity

Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 10 μ M) that is selective over insulin receptor kinase. Blocks tyrosine phosphorylation of p145 met and promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro .

References

[1]. gazit a, osherov n, gilon c, et al. tyrphostins. 6. dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of egf receptor tyrosine kinase in vitro. j med chem, 1996, 39(25): 4905-4911.
[2]. yamamoto n, mammadova g, song rx, et al. tyrosine phosphorylation of p145met mediated by egfr and src is required for serum-independent survival of human bladder carcinoma cells. j cell sci, 2006, 119(pt 22): 4623-4633.

AG 99 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

AG 99 Suppliers

China 57 Europe 2 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 3 United States 15 USA 1 Global 82
Chengdu Kamel Pharmaceutical Co., Ltd
Tel
028-67136579 15828051124
Email
sales@kamelpharm.com
Country
China
ProdList
1885
Advantage
55
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4600
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
10566
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
22883
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29811
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988968278
Fax
QQ：3283937693
Email
sales@ubiochem.com
Country
China
ProdList
4297
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel
+86-021-61551413 +8618813727289
Email
contact@trustwe.com
Country
China
ProdList
5738
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44808
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
Hefei Mokai Pharmaceutical Technology Co., Ltd
Tel
18130062233
Email
3362556465@qq.com
Country
China
ProdList
7999
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62163
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50749
Advantage
58
Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Country
China
ProdList
6813
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12005
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48461
Advantage
58
Shaoguan Qicheng Biotechnology Co., Ltd
Tel
18122215013
Email
780229652@qq.com
Country
China
ProdList
1163
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
Tel
13915962545
Email
2881759498@qq.com
Country
China
ProdList
2016
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
32957
Advantage
60
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
Tel
+86-86-22-87899925 +86-8618522618860
Fax
86-22-87899925
Email
18522618860@163.com
Country
China
ProdList
694
Advantage
58
Shanghai Haoran Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
470003480@QQ.COM
Country
CHINA
ProdList
6955
Advantage
58
Shanghai Chaoyan Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
471161314@qq.com
Country
CHINA
ProdList
6210
Advantage
58
Beijing Dongge Boye Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1861586486@qq.com
Country
CHINA
ProdList
6648
Advantage
58
Beijing Taize Jiaye Technology Development Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6050
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
Shanghai Haoyang Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
596799915@QQ.COM
Country
CHINA
ProdList
2905
Advantage
58
Shanghai Yijie Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
SHYIJIEBIO@126.COM
Country
CHINA
ProdList
3510
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Beijing Fubo Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
info@f-biology.com
Country
CHINA
ProdList
6025
Advantage
58
Morning Student Science and Technology (Guangzhou) Co., Ltd.
Tel
--
Fax
--
Email
chenxue_gz@163.com
Country
CHINA
ProdList
6600
Advantage
58
Shanghai Ziqi Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
2453006496@qq.com
Country
CHINA
ProdList
6184
Advantage
58
Resenbio
Tel
--
Fax
--
Email
sales@xarxbio.com
Country
China
ProdList
1774
Advantage
50
Xiamen Huijia Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6973
Advantage
58
Beijing Lebo Biotechnology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6057
Advantage
58
Xiamen Research Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1562893815@qq.com
Country
CHINA
ProdList
6936
Advantage
58
Beijing Bi Orange Blue Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
bo49855987@163.com
Country
CHINA
ProdList
6827
Advantage
58
Shenzhen Xinbosheng Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
service@neobioscience.com
Country
CHINA
ProdList
6151
Advantage
58
Beijing Bolide Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1985563437@qq.com
Country
CHINA
ProdList
6158
Advantage
58
More
Less

View Lastest Price from AG 99 manufacturers

Career Henan Chemical Co
Product
AG 99 122520-85-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

122520-85-8, AG 99Related Search:

TYRPHOSTIN AG 126 TYRPHOSTIN AG 835 AG 18 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol 220127-57-1 AG 99 NS-398 AG 213

  • TYRPHOSTIN AG 99
  • TYRPHOSTIN B40
  • TYRPHOSTIN 46
  • TYRPHOSTIN A46
  • 3,4-DIHYDROXY-ALPHA-CYANOCINNAMIDE
  • ALPHA-CYANO-(3,4-DIHYDROXY)CINNAMIDE
  • AG 99
  • (E)-2-Cyano-3-(3,4-dihydroxyphenyl)acrylamide
  • (E)-2-Cyano-3-(3,4-dihydroxyphenyl)propenamide
  • (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-2-PROPENAMIDE
  • TYRPHOSTIN A46 99%
  • 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)
  • (E)-AG 99
  • (E)-Tyrphostin 46
  • (E)-Tyrphostin AG 99
  • 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-
  • 2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
  • AG 99 USP/EP/BP
  • (E)-AG 99 (AG99)
  • inhibit,Inhibitor,(E) AG 99,Epidermal growth factor receptor,HER1,ErbB-1,EGFR,(E)AG 99,(E)-AG 99
  • 122520-85-8
  • ALCOHOL
  • Intracellular Signaling