ChemicalBook > CAS DataBase List > AG 825

AG 825

Product Name
AG 825
CAS No.
149092-50-2
Chemical Name
AG 825
Synonyms
AG 825;Zinc02572484;TYRPHOSTIN C15;AG 825 USP/EP/BP;TYRPHOSTIN AG 825;AG-825, 10 mM in DMSO;AG 825, ErbB2 inhibitor;AG 825 (Tyrphostin AG 825);AG 825 - CAS 149092-50-2 - Calbiochem;4-HYDROXY-3-METHOXY-5-(BENZOTHIAZOLYLTHIOMETHYL)BENZYLIDENECYANOACETAMIDE
CBNumber
CB1283828
Molecular Formula
C19H15N3O3S2
Formula Weight
397.47
MOL File
149092-50-2.mol
More
Less

AG 825 Property

storage temp. 
−20°C
solubility 
DMSO: soluble
form 
Yellow solid
color 
Light yellow to yellow
Sensitive 
Light Sensitive
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T5443
Product name
Tyrphostin AG 825
Purity
≥92.5%
Packaging
2mg
Price
$110.2
Updated
2025/07/31
Sigma-Aldrich
Product number
121765
Product name
AG 825
Packaging
2mg
Price
$177
Updated
2025/07/31
Cayman Chemical
Product number
10010243
Product name
AG 825
Purity
≥98%
Packaging
1mg
Price
$28
Updated
2024/03/01
Cayman Chemical
Product number
10010243
Product name
AG 825
Purity
≥98%
Packaging
5mg
Price
$90
Updated
2024/03/01
Cayman Chemical
Product number
10010243
Product name
AG-825
Purity
≥98%
Packaging
25 mg
Price
$345
Updated
2024/03/01
More
Less

AG 825 Chemical Properties,Usage,Production

Uses

A selective ErbB2 inhibitor

Uses

AG 825 is a selective ErbB2 (Neu) inhibitor and apoptosis inducer.

Definition

ChEBI: An organic sulfide that consists of 1,3-benzothiazole-2-thiol in which the hydrogen attached to the sulfur atom is replaced by a 5-[(1E)-3-amino-2-cyano-3-oxoprop-1-en-1-yl]-2-hydroxy-3-methoxybenzyl group. It acts as an epidermal growth factor receptor antagonist.

Biological Activity

Selective ErbB2 inhibitor (IC 50 values are 0.15 and 19 mM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.

in vivo

AG-825 (20 mg/kg, i.p.) decreases peritoneal inflammation in Zymosan (HY-159069)-treated mice, and increases lung neutrophil apoptosis and macrophage efferocytosis in a murine acute lung injury model[4].
AG-825 (1 mg/kg, min-osmotic pump, 14 days) causes cardiac dilation and selective increase in β1AR density in mice[7].

Animal Model:Murine model of LPS induced acute lung inflammation[4]
Dosage:20 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Had no effect on percentage of, or absolute number of neutrophils or macrophages.
Increased the percentage of neutrophil apoptosis.
Elevated macrophage efferocytosis.
Animal Model:Murine model of Zymosan (HY-159069)-induced peritonitis[4]
Dosage:20 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Did not induce leukopenia.
Showed fewer inflammatory cells in peritoneal lavage.
Reduced the neutrophil chemoattractant and proinflammatory cytokine, KC.
Reduced IgM.

IC 50

ErbB2: 0.35 μM (IC50); EGFR: 19 μM (IC50)

storage

Store at +4°C

AG 825 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

AG 825 Suppliers

China 75 Germany 4 India 1 Switzerland 2 United Kingdom 5 United States 23 USA 1 Global 111
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Suzhou Chireach Biomedical Technology Co., Ltd.
Tel
0512-65856968
Fax
0512-65647218
Email
sales@chireach.com
Country
China
ProdList
59
Advantage
70
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Synchem OHG
Tel
+49 5662 408730
Fax
+49 5662 4087320
Email
info@synchem.de
Country
Germany
ProdList
4705
Advantage
70
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9021
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9119
Advantage
58

149092-50-2, AG 825Related Search:

AG 1478 HYDROCHLORIDE DAPH AG 18 LAVENDUSTIN A METHYL 2,5-DIHYDROXYCINNAMATE H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH TYRPHOSTIN A25 Canertinib 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol AG 213 4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE PD168393 TYRPHOSTIN A51 CIVENTICHEM CV-409 AG 825 AG 99 4-METHYL-2-[(METHYLTHIO)METHYL]PHENOL AKOS BBS-00008114

  • TYRPHOSTIN AG 825
  • TYRPHOSTIN C15
  • AG 825
  • 5-[(BENZTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYLIDENECYANOACETAMIDE
  • 5-[(BENZOTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYL-IDENECYANOACETAMIDE
  • 4-HYDROXY-3-METHOXY-5-(BENZOTHIAZOLYLTHIOMETHYL)BENZYLIDENECYANOACETAMIDE
  • 3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano- 2-Propenamide
  • Tyrphostin C15, 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide
  • AG 825 (Tyrphostin AG 825)
  • (E)-3-[3-[(2-BENZOTHIAZOLYTHIO)METHYL]-4-HYDROXY-5-METHOXYPHENYL]-2-CYANO-2-PROPENAMIDE
  • AG 825 - CAS 149092-50-2 - Calbiochem
  • Zinc02572484
  • 2-Propenamide, 3-[3-[(2-benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-
  • AG 825 USP/EP/BP
  • 3-(3-((Benzo[d]thiazol-2-ylthio)methyl)-4-hydroxy-5-methoxyphenyl)-2-cyanoacrylamide
  • AG 825, ErbB2 inhibitor
  • AG-825, 10 mM in DMSO
  • 149092-50-2
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Kinase/Phosphatase Biology
  • Receptor Tyrosine Kinase Inhibitors
  • Epidermal Growth Factor Receptor (EGFR)
  • Protein Kinase