4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE
- Product Name
- 4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE
- CAS No.
- 171745-13-4
- Chemical Name
- 4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE
- Synonyms
- EGFR-IN-80;COMPOUND 56;N-(3-Bromophenyl)-6,7-diethoxy-4-quinazolinamine;N-(3-broMophenyl)-6,7-diethoxyquinazolin-4-aMine;4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE;4-Quinazolinamine, N-(3-bromophenyl)-6,7-diethoxy-
- CBNumber
- CB8784430
- Molecular Formula
- C18H18BrN3O2
- Formula Weight
- 388.26
- MOL File
- Mol file
4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE Property
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥16.95 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
- form
- White to off-white powder.
N-Bromosuccinimide Price
- Product number
- 17254
- Product name
- Compound 56
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $238
- Updated
- 2024/03/01
- Product number
- 17254
- Product name
- Compound 56
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $452
- Updated
- 2024/03/01
- Product number
- A8197
- Product name
- Compound56
- Packaging
- 1unit
- Price
- $28
- Updated
- 2021/12/16
- Product number
- A8197
- Product name
- Compound56
- Packaging
- 500ug
- Price
- $50
- Updated
- 2021/12/16
- Product number
- A8197
- Product name
- Compound56
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE Chemical Properties,Usage,Production
Uses
Compound 56 is a potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor.
Biological Activity
compound 56, 4-[(3-bromophenyl)amino]-6,7-diethoxyquinazoline, is a potent and specific inhibitor of the tyrosine kinase of the epidermal growth factor receptor (egfr) showing an ic50 of 0.006 nm. it competitively binds at the adenosine-triphosphate (atp) site of egfr. compound 56 is capable of inhibiting the phosphorylation of egf-dependent egfr, suppressing the proliferation and clonogenicity of a wide panel of egfr-overexpressing human cancer lines, and blocking egf-mediated mitogenesis and oncogenic transformation in fibroblasts overexpressing egfr. besides inhibiting egfr tyrosine kinase, it also inhibits the tyrosine kinase of human epidermal growth factor receptor 2 (her2/neu) but with a less potency.bridges aj, zhou h, cody dr, rewcastle gw, mcmichael a, showalter hd, fry dw, kraker aj, and denny wa. tyrosine kinase inhibitors. 8. an unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (pd 153035), a potent inhibitor of the epidermal growth factor receptor.j med chem 1966; 39 (1): 267-276monique bos, jhn mendelsohn, young-mee kim, joan albanell, david w. fry, and jose baelga. pd153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. clin cancer res 1997;3:2099-2106
target
EGFR
4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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