ChemicalBook > CAS DataBase List > AG 825

AG 825

Product Name
AG 825
CAS No.
149092-50-2
Chemical Name
AG 825
Synonyms
AG 825;Zinc02572484;TYRPHOSTIN C15;AG 825 USP/EP/BP;TYRPHOSTIN AG 825;AG 825, ErbB2 inhibitor;AG 825 (Tyrphostin AG 825);AG 825 - CAS 149092-50-2 - Calbiochem;4-HYDROXY-3-METHOXY-5-(BENZOTHIAZOLYLTHIOMETHYL)BENZYLIDENECYANOACETAMIDE;5-[(BENZTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYLIDENECYANOACETAMIDE
CBNumber
CB1283828
Molecular Formula
C19H15N3O3S2
Formula Weight
397.47
MOL File
149092-50-2.mol
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AG 825 Property

storage temp. 
−20°C
solubility 
DMSO: soluble
form 
Yellow solid
color 
Light yellow to yellow
Sensitive 
Light Sensitive
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T5443
Product name
Tyrphostin AG 825
Purity
≥92.5%
Packaging
2mg
Price
$52.8
Updated
2024/03/01
Sigma-Aldrich
Product number
121765
Product name
AG 825
Packaging
2mg
Price
$172
Updated
2024/03/01
Alfa Aesar
Product number
J65227
Product name
Tyrphostin C15
Packaging
10mg
Price
$233.65
Updated
2024/03/01
Cayman Chemical
Product number
10010243
Product name
AG 825
Purity
≥98%
Packaging
1mg
Price
$28
Updated
2024/03/01
Cayman Chemical
Product number
10010243
Product name
AG 825
Purity
≥98%
Packaging
5mg
Price
$90
Updated
2024/03/01
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AG 825 Chemical Properties,Usage,Production

Uses

A selective ErbB2 inhibitor

Uses

AG 825 is a selective ErbB2 (Neu) inhibitor and apoptosis inducer.

Definition

ChEBI: An organic sulfide that consists of 1,3-benzothiazole-2-thiol in which the hydrogen attached to the sulfur atom is replaced by a 5-[(1E)-3-amino-2-cyano-3-oxoprop-1-en-1-yl]-2-hydroxy-3-methoxybenzyl group. It acts as an epidermal growth factor receptor antagonist.

Biological Activity

Selective ErbB2 inhibitor (IC 50 values are 0.15 and 19 mM at ErbB2 and ErbB1 respectively). Preferentially triggers p38 MAP kinase-dependent apoptosis in androgen-independent prostate cancer cells.

storage

Store at +4°C

AG 825 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 825 Suppliers

China 60 Germany 4 India 1 Switzerland 2 United Kingdom 5 United States 23 USA 1 Global 96
3B Pharmachem (Wuhan) International Co.,Ltd.
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LETOPHARM LIMITED
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RD International Technology Co., Limited
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149092-50-2, AG 825Related Search:

AG 1478 HYDROCHLORIDE DAPH AG 18 LAVENDUSTIN A METHYL 2,5-DIHYDROXYCINNAMATE H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH TYRPHOSTIN A25 Canertinib 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol AG 213 4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE PD168393 TYRPHOSTIN A51 CIVENTICHEM CV-409 AG 825 AG 99 4-METHYL-2-[(METHYLTHIO)METHYL]PHENOL AKOS BBS-00008114

  • TYRPHOSTIN AG 825
  • TYRPHOSTIN C15
  • AG 825
  • 5-[(BENZTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYLIDENECYANOACETAMIDE
  • 5-[(BENZOTHIAZOL-2-YL)THIOMETHYL]-4-HYDROXY-3-METHOXYBENZYL-IDENECYANOACETAMIDE
  • 4-HYDROXY-3-METHOXY-5-(BENZOTHIAZOLYLTHIOMETHYL)BENZYLIDENECYANOACETAMIDE
  • 3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano- 2-Propenamide
  • Tyrphostin C15, 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide
  • AG 825 (Tyrphostin AG 825)
  • (E)-3-[3-[(2-BENZOTHIAZOLYTHIO)METHYL]-4-HYDROXY-5-METHOXYPHENYL]-2-CYANO-2-PROPENAMIDE
  • AG 825 - CAS 149092-50-2 - Calbiochem
  • Zinc02572484
  • 2-Propenamide, 3-[3-[(2-benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-
  • AG 825 USP/EP/BP
  • 3-(3-((Benzo[d]thiazol-2-ylthio)methyl)-4-hydroxy-5-methoxyphenyl)-2-cyanoacrylamide
  • AG 825, ErbB2 inhibitor
  • 149092-50-2
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Kinase/Phosphatase Biology
  • Receptor Tyrosine Kinase Inhibitors
  • Epidermal Growth Factor Receptor (EGFR)
  • Protein Kinase