AG 213
- Product Name
- AG 213
- CAS No.
- 122520-86-9
- Chemical Name
- AG 213
- Synonyms
- AG 213;RG-50864;TYRPHOSTIN 47;TYRPHOSTIN A47;AG 213 USP/EP/BP;TYRPHOSTIN AG 213;TYRPHOSTIN A47 99+%;TYRPHOSTIN RG 50864;AG 213 (Tyrphostin AG 213);ZGHQGWOETPXKLY-XVNBXDOJSA-N
- CBNumber
- CB5152917
- Molecular Formula
- C10H8N2O2S
- Formula Weight
- 220.25
- MOL File
- 122520-86-9.mol
AG 213 Property
- Melting point:
- 213 °C
- Boiling point:
- 474.5±55.0 °C(Predicted)
- Density
- 1.512±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 50 mg/mL, clear, orange
- form
- Orange solid.
- pka
- 8.82±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- J67345
- Product name
- Tyrphostin AG-213
- Purity
- 97%
- Packaging
- 5mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- J67345
- Product name
- Tyrphostin AG-213
- Purity
- 97%
- Packaging
- 10mg
- Price
- $151
- Updated
- 2021/12/16
- Product number
- 10010314
- Product name
- AG-213
- Purity
- ≥97%
- Packaging
- 5mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 10010314
- Product name
- AG-213
- Purity
- ≥97%
- Packaging
- 10mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- J67345
- Product name
- Tyrphostin AG-213
- Purity
- 97%
- Packaging
- 25mg
- Price
- $356
- Updated
- 2021/12/16
AG 213 Chemical Properties,Usage,Production
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-
Uses
Tyrphostin 47 is a potent inhibitor of EGFR kinase activity.
Definition
ChEBI: 3-amino-2-[(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-mercapto-2-propenenitrile is a member of quinomethanes.
Biological Activity
Epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC 50 values are 2.4 and 3 μ M respectively). Stimulates microtubule polymerization and promotes neurite outgrowth > 17-fold over basal conditions in vitro . Also weakly inhibits protein kinase C (IC 50 = 60 μ M).
References
[1] romer l h, mclean n, turner c e, et al. tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells[j]. molecular biology of the cell, 1994, 5(3): 349-361.
[2] gazit a, yaish p, gilon c, et al. tyrphostins i: synthesis and biological activity of protein tyrosine kinase inhibitors[j]. journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[3] levitzki a, gazit a. tyrosine kinase inhibition: an approach to drug development[j]. science, 1995, 267(5205): 1782.
[4] herbst r s. review of epidermal growth factor receptor biology[j]. international journal of radiation oncology biology physics, 2004, 59(2): s21-s26.