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AG 213

Product Name
AG 213
CAS No.
122520-86-9
Chemical Name
AG 213
Synonyms
AG 213;RG-50864;TYRPHOSTIN 47;TYRPHOSTIN A47;AG 213 USP/EP/BP;TYRPHOSTIN AG 213;TYRPHOSTIN A47 99+%;TYRPHOSTIN RG 50864;AG 213 (Tyrphostin AG 213);ZGHQGWOETPXKLY-XVNBXDOJSA-N
CBNumber
CB5152917
Molecular Formula
C10H8N2O2S
Formula Weight
220.25
MOL File
122520-86-9.mol
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AG 213 Property

Melting point:
213 °C
Boiling point:
474.5±55.0 °C(Predicted)
Density 
1.512±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 50 mg/mL, clear, orange
form 
Orange solid.
pka
8.82±0.10(Predicted)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J67345
Product name
Tyrphostin AG-213
Purity
97%
Packaging
5mg
Price
$104
Updated
2021/12/16
Alfa Aesar
Product number
J67345
Product name
Tyrphostin AG-213
Purity
97%
Packaging
10mg
Price
$151
Updated
2021/12/16
Cayman Chemical
Product number
10010314
Product name
AG-213
Purity
≥97%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
10010314
Product name
AG-213
Purity
≥97%
Packaging
10mg
Price
$107
Updated
2024/03/01
Alfa Aesar
Product number
J67345
Product name
Tyrphostin AG-213
Purity
97%
Packaging
25mg
Price
$356
Updated
2021/12/16
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AG 213 Chemical Properties,Usage,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-213 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 2.4 μM in the human epidermoid carcinoma cell line A431.

Uses

Tyrphostin 47 is a potent inhibitor of EGFR kinase activity.

Definition

ChEBI: 3-amino-2-[(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-mercapto-2-propenenitrile is a member of quinomethanes.

Biological Activity

Epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC 50 values are 2.4 and 3 μ M respectively). Stimulates microtubule polymerization and promotes neurite outgrowth > 17-fold over basal conditions in vitro . Also weakly inhibits protein kinase C (IC 50 = 60 μ M).

References

[1] romer l h, mclean n, turner c e, et al. tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells[j]. molecular biology of the cell, 1994, 5(3): 349-361.
[2] gazit a, yaish p, gilon c, et al. tyrphostins i: synthesis and biological activity of protein tyrosine kinase inhibitors[j]. journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[3] levitzki a, gazit a. tyrosine kinase inhibition: an approach to drug development[j]. science, 1995, 267(5205): 1782.
[4] herbst r s. review of epidermal growth factor receptor biology[j]. international journal of radiation oncology biology physics, 2004, 59(2): s21-s26.

AG 213 Preparation Products And Raw materials

Raw materials

Preparation Products

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AG 213 Suppliers

China 28 Germany 3 India 1 Switzerland 2 United Kingdom 3 United States 10 Global 47
3B Pharmachem (Wuhan) International Co.,Ltd.
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122520-86-9, AG 213Related Search:

AG 18 TYRPHOSTIN A9 TYRPHOSTIN A25 Canertinib TYRPHOSTIN A51 AG 1295 AG 490 AG 1478 NS-398 BIS-TYRPHOSTIN AG 825 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI) TYRPHOSTIN A63 TYRPHOSTIN A1 AG 99 TYRPHOSTIN AG 1288 AG 213,TYRPHOSTIN AG 213 (E)-N-(3''-PHENYLPROPYL-ALPHA-CYANO-3'-5'-DIISOPROPYL-4'-HYDROXYCINNAMAMIDE)

  • ALPHA-CYANO-3,4-DIHYDROXYTHIOCINNAMAMIDE
  • ALPHA-CYANO-(3,4-DIHYDROXY)THIOCINNAMIDE
  • AG 213
  • 3,4-DIHYDROXY-ALPHA-CYANOTHIOCINNAMAMIDE
  • (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-2-PROPENTHIOAMIDE
  • TYRPHOSTIN A47 99+%
  • AG 213 (Tyrphostin AG 213)
  • ZGHQGWOETPXKLY-XVNBXDOJSA-N
  • TYRPHOSTIN 47
  • TYRPHOSTIN A47
  • TYRPHOSTIN AG 213
  • TYRPHOSTIN RG 50864
  • RG-50864
  • 3-amino-2-[(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile
  • AG 213 USP/EP/BP
  • 2-Propenethioamide, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)-
  • 122520-86-9
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Biochemicals and Reagents
  • Substrate Analogs
  • Receptor Tyrosine Kinase Inhibitors
  • Epidermal Growth Factor Receptor (EGFR)
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Type
  • Enzyme Inhibitors
  • Kinase/Phosphatase Biology
  • Intracellular Signaling
  • Protein Kinase