Semagacestat

Product Name: Semagacestat
CAS No.: 425386-60-3
Chemical Name: Semagacestat
Synonyms: LY450139;CS-1679;LY-4501);semagacestat;Unii-3yn0602W4w;Semagacestat/LY-450139;LY450139(Semagacestat);LY450139; LY-450139; LY 450139;Semagacestat LY450139 LY-450139;N-benzyl-4-MethylcyclohexanaMine
CBNumber: CB71511579
Molecular Formula: C19H27N3O4
Formula Weight: 361.44
MOL File: 425386-60-3.mol

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Semagacestat Property

Melting point:: 208-212 °C
Boiling point:: 681.9±55.0 °C(Predicted)
Density: 1.22
Flash point:: 366.2℃
storage temp.: 2-8°C
solubility: DMSO (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
form: Solid
pka: 12.97±0.20(Predicted)
color: White

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Safety

HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16713
Product name: Semagacestat
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 16713
Product name: Semagacestat
Purity: ≥98%
Packaging: 5mg
Price: $90
Updated: 2024/03/01

Cayman Chemical

Product number: 16713
Product name: Semagacestat
Purity: ≥98%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 16713
Product name: Semagacestat
Packaging: 25mg
Price: $353
Updated: 2024/03/01

Tocris

Product number: 6559
Product name: LY450139
Purity: ≥98%(HPLC)
Packaging: 25
Price: $322
Updated: 2021/12/16

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Semagacestat Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Semagacestat is an inhibitor of the γ-secretase enzyme. γ-Secretase enzyme is pivotal in the generation of β-amyloid (Aβ), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer''s disease (AD).

Definition

ChEBI: (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide is a peptide.

Biological Activity

semagacestat (also known as ly450139), [(2s)-2-hydroxy-n-((2s)-1-((1s)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1h-benzo[d]azepin-1ylamino)-1-oxopropan-2-yl)-3-methylbutanamide] is an azepine class γ-secretase, which is currently being investigated as a potential disease-modifying agent for the treatment of alzheimer’s disease (ad). it reduces the rate of formation of amyloid-β (aβ), a major component of the neuritic plaque in the brains of ad patients, in human subjects and animal models including mice, beagle dogs and guinea pigs. according to previous studies, semagacestat slows the accumulation of aβ in the brains of transgenic mice overexpressing mutant human amyloid precursor protein v717f (pdapp mice) and exhibits a dose-dependent decrease of plasma in ad patients.ping yi, chad hadden, palaniappan kulanthaivel, nathan calvert, william annes, thomas brown, robert j. barbuch, archana chaudhary, mosun a. ayan-oshodi, and barbara j. ring. disposition and metabolism of semagacestat, a γ-secretase inhibitor, in humans. drug metabolism and disposition 2010; 38(4): 554-565

target

Aβ42

storage

Store at -20°C

Semagacestat Preparation Products And Raw materials

Raw materials

Preparation Products

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Semagacestat Suppliers

Canada 1 China 102 India 2 United Kingdom 2 United States 19 Global 126

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

ChemFuture PharmaTech (Jiangsu) Ltd

Tel: 5108538618
Fax: 86 510 85386988-8017
Email: suger.wang@chemfuture.com
Country: China
ProdList: 832
Advantage: 65

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9809
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 021-51613915-820 13611835272
Fax: 021 51613951
Email: mmwang@sunwaypharm.cn
Country: China
ProdList: 9734
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 9387
Advantage: 52

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

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View Lastest Price from Semagacestat manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Semagacestat 425386-60-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

425386-60-3, SemagacestatRelated Search:

10-Hydroxycamptothecin PENICILLIN V HYDROXYAPATITE TYPE I 4-Hydroxybenzaldehyde Bensulfuron methyl CHLOROPHOSPHONAZO III Glycolic acid Hydroxy silicone oil Methylparaben Methyl acrylate Thiophanate-methyl Kresoxim-methyl Methyl 2H-3-BENZAZEPIN-2-ONE,1-AMINO-1,3,4,5-TETRAHYDRO-3-METHYL-,(1S)- 1-amino-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one Parathion-methyl Glycolonitrile Butyramide

(2S)-2-HYDROXY-3-METHYL-N-[(2S)-1-{[(1S)-3-METHYL-2-OXO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPIN-1-YL]AMINO}-1-OXOPROPAN-2-YL]BUTANAMIDE

semagacestat

Butanamide, 2-hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5- tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]-, (2S)-

(2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide

Semagacestat/LY-450139

Unii-3yn0602W4w

LY450139(Semagacestat)

LY450139

2-hydroxy-3-Methyl-N-[(1S)-1-Methyl-2-oxo-2-[[(1S)-2

5-tetrahydro-3-Methyl-2-oxo-1H-3-benzazepin-1-yl]aMino]ethyl]-

N-benzyl-4-MethylcyclohexanaMine

(2S)-2-hydroxy-3-Methyl-N-[(1S)-1-{[(1S)-3-Methyl-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepin-1-yl]carbaMoyl}ethyl]butanaMide

(S)-2-Hydroxy-3-methyl-N-((S)-1-((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yla

CS-1679

LY450139; LY-450139; LY 450139

Semagacestat (Synonyms: LY450139)

LY-4501)

Semagacestat LY450139 LY-450139

425386-60-3

C19H27O4N3

Inhibitor

Inhibitors