Semagacestat
- Product Name
- Semagacestat
- CAS No.
- 425386-60-3
- Chemical Name
- Semagacestat
- Synonyms
- LY450139;CS-1679;LY-4501);semagacestat;Unii-3yn0602W4w;Semagacestat/LY-450139;LY450139(Semagacestat);LY450139; LY-450139; LY 450139;Semagacestat LY450139 LY-450139;N-benzyl-4-MethylcyclohexanaMine
- CBNumber
- CB71511579
- Molecular Formula
- C19H27N3O4
- Formula Weight
- 361.44
- MOL File
- 425386-60-3.mol
Semagacestat Property
- Melting point:
- 208-212 °C
- Boiling point:
- 681.9±55.0 °C(Predicted)
- Density
- 1.22
- Flash point:
- 366.2℃
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 12.97±0.20(Predicted)
- color
- White
Safety
- HS Code
- 29337900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 16713
- Product name
- Semagacestat
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 16713
- Product name
- Semagacestat
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2024/03/01
- Product number
- 16713
- Product name
- Semagacestat
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 16713
- Product name
- Semagacestat
- Packaging
- 25mg
- Price
- $353
- Updated
- 2024/03/01
- Product number
- 6559
- Product name
- LY450139
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $322
- Updated
- 2021/12/16
Semagacestat Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Semagacestat is an inhibitor of the γ-secretase enzyme. γ-Secretase enzyme is pivotal in the generation of β-amyloid (Aβ), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer''s disease (AD).
Definition
ChEBI: (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide is a peptide.
Biological Activity
semagacestat (also known as ly450139), [(2s)-2-hydroxy-n-((2s)-1-((1s)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1h-benzo[d]azepin-1ylamino)-1-oxopropan-2-yl)-3-methylbutanamide] is an azepine class γ-secretase, which is currently being investigated as a potential disease-modifying agent for the treatment of alzheimer’s disease (ad). it reduces the rate of formation of amyloid-β (aβ), a major component of the neuritic plaque in the brains of ad patients, in human subjects and animal models including mice, beagle dogs and guinea pigs. according to previous studies, semagacestat slows the accumulation of aβ in the brains of transgenic mice overexpressing mutant human amyloid precursor protein v717f (pdapp mice) and exhibits a dose-dependent decrease of plasma in ad patients.ping yi, chad hadden, palaniappan kulanthaivel, nathan calvert, william annes, thomas brown, robert j. barbuch, archana chaudhary, mosun a. ayan-oshodi, and barbara j. ring. disposition and metabolism of semagacestat, a γ-secretase inhibitor, in humans. drug metabolism and disposition 2010; 38(4): 554-565
target
Aβ42
storage
Store at -20°C
Semagacestat Preparation Products And Raw materials
Raw materials
Preparation Products
Semagacestat Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from Semagacestat manufacturers
- Product
- Semagacestat 425386-60-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26