Fatostatin A

Product Name: Fatostatin A
CAS No.: 125256-00-0
Chemical Name: Fatostatin A
Synonyms: 125B11;Fatostatin, 10 mM in DMSO;2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole;Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-;4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole;mice,125B11,prostate,cancer,Fatty Acid Synthase (FASN),gene,human,insulin-induced,Fatostatin,ob/ob,inhibit,expression,Golgi,Inhibitor,adipogenesis,SREBP-mediated
CBNumber: CB92627880
Molecular Formula: C18H18N2S
Formula Weight: 294.41
MOL File: 125256-00-0.mol

More

Less

Fatostatin A Property

Boiling point:: 474.3±55.0 °C(Predicted)
Density: 1.125±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in DMSO (up to 25 mg/ml).
pka: 3.46±0.10(Predicted)
form: solid
color: Yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-5810
Product name: Fatostatin
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-5810
Product name: Fatostatin
Packaging: 10mg
Price: $78
Updated: 2021/12/16

ChemScene

Product number: CS-5810
Product name: Fatostatin
Packaging: 25mg
Price: $145
Updated: 2021/12/16

ChemScene

Product number: CS-5810
Product name: Fatostatin
Packaging: 50mg
Price: $245
Updated: 2021/12/16

ChemScene

Product number: CS-5810
Product name: Fatostatin
Packaging: 100mg
Price: $420
Updated: 2021/12/16

More

Less

Fatostatin A Chemical Properties,Usage,Production

Description

Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice.1?Inhibits high glucose-induced TGF-β in mesangial cells.2?Cell permeable.

Uses

Fatostatin A is Cell permeable inhibitor of SREBP activation.

Definition

ChEBI: 4-(4-methylphenyl)-2-(2-propyl-4-pyridinyl)thiazole is a member of thiazoles.

in vivo

Fatostatin (125B11) (30 mg/kg; 150 μL; i.p. injection; daily for 28 days) reduces adiposity, ameliorated fatty liver by reducing triglyceride (TG) storage, and lowered hyperglycemia in ob/ob mice^[2].

Animal Model:	Four-to-five-week-old homozygous male obese (ob/ob) mice (C57BL/6J)^[2]
Dosage:	30 mg/kg; 150 μL
Administration:	i.p. injection; daily for 28 days
Result:	Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.

References

[1] SHINJI KAMISUKI. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.[J]. Chemistry & biology, 2009: 882-892. DOI:10.1016/j.chembiol.2009.07.007
[2] LALITA UTTARWAR. SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells.[J]. American Journal of Physiology-renal Physiology, 2012, 302 3: F329-41. DOI:10.1152/ajprenal.00136.2011

Fatostatin A Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Fatostatin A Suppliers

China 54 United States 8 Global 62

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Mashilabs (Shanghai) Co.,Ltd.

Tel: 19916721580
Fax: QQ：3154870176
Email: mafarm@126.com
Country: China
ProdList: 4542
Advantage: 58

Shanghai Race Chemical Co., Ltd.

Tel: 86-021-54933292
Fax: 86-021-54933292
Email: sales@racechemical.com
Country: China
ProdList: 239
Advantage: 50

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 984
Advantage: 55

Twochem Co.Ltd

Tel: 021-021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 304
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

125256-00-0, Fatostatin ARelated Search:

EPA METYRAPONE Ginkgolide B Palmitoylethanolamide XL-647 N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl BMS 777607 Fatostatin A TMC-207

4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole

125B11

Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-

2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole

mice,125B11,prostate,cancer,Fatty Acid Synthase (FASN),gene,human,insulin-induced,Fatostatin,ob/ob,inhibit,expression,Golgi,Inhibitor,adipogenesis,SREBP-mediated

Fatostatin, 10 mM in DMSO

125256-00-0