Fatostatin A

Product Name: Fatostatin A
CAS No.: 125256-00-0
Chemical Name: Fatostatin A
Synonyms: 125B11;2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole;Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-;4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole;mice,125B11,prostate,cancer,Fatty Acid Synthase (FASN),gene,human,insulin-induced,Fatostatin,ob/ob,inhibit,expression,Golgi,Inhibitor,adipogenesis,SREBP-mediated
CBNumber: CB92627880
Molecular Formula: C18H18N2S
Formula Weight: 294.41
MOL File: 125256-00-0.mol

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Fatostatin A Property

Boiling point:: 474.3±55.0 °C(Predicted)
Density: 1.125±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in DMSO (up to 25 mg/ml).
pka: 3.46±0.10(Predicted)
form: solid
color: Yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5810
Product name: Fatostatin
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-5810
Product name: Fatostatin
Packaging: 10mg
Price: $78
Updated: 2021/12/16

ChemScene

Product number: CS-5810
Product name: Fatostatin
Packaging: 25mg
Price: $145
Updated: 2021/12/16

ChemScene

Product number: CS-5810
Product name: Fatostatin
Packaging: 50mg
Price: $245
Updated: 2021/12/16

ChemScene

Product number: CS-5810
Product name: Fatostatin
Packaging: 100mg
Price: $420
Updated: 2021/12/16

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Fatostatin A Chemical Properties,Usage,Production

Description

Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice.1?Inhibits high glucose-induced TGF-β in mesangial cells.2?Cell permeable.

Uses

Fatostatin A is Cell permeable inhibitor of SREBP activation.

Definition

ChEBI: 4-(4-methylphenyl)-2-(2-propyl-4-pyridinyl)thiazole is a member of thiazoles.

References

1) Kamisuki et al. (2009), A small molecule that blocks fat synthesis by inhibiting the activation of SREBP; Chem. Biol., 16 882 2) Uttarwar et al. (2012), SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells; Am. J. Physiol. Renal Physiol., 302 F329

Fatostatin A Preparation Products And Raw materials

Raw materials

Preparation Products

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Fatostatin A Suppliers

China 42 United States 8 Global 50

Adamas Reagent, Ltd.

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Haoyuan Chemexpress Co., Ltd.

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MedChemexpress LLC

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Mashilabs (Shanghai) Co.,Ltd.

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Shanghai Race Chemical Co., Ltd.

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BePharm Ltd

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125256-00-0, Fatostatin ARelated Search:

EPA METYRAPONE Ginkgolide B Palmitoylethanolamide XL-647 N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl BMS 777607 Fatostatin A TMC-207

4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole

125B11

Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-

2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole

mice,125B11,prostate,cancer,Fatty Acid Synthase (FASN),gene,human,insulin-induced,Fatostatin,ob/ob,inhibit,expression,Golgi,Inhibitor,adipogenesis,SREBP-mediated

125256-00-0