ChemicalBook > CAS DataBase List > N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl

Product Name
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
CAS No.
902135-91-5
Chemical Name
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
Synonyms
CS-266;AT 7519;AT7519 HCl;AT-7519(HCI);AT-7519 diHCl;AT7519; AT-7519;AT 7519 HCl salt;AT7519 HCl, >=99%;Light yellow solid;AT7519 (Hydrochloride)
CBNumber
CB52473801
Molecular Formula
C16H18Cl3N5O2
Formula Weight
418.7
MOL File
902135-91-5.mol
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N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Property

storage temp. 
Store at -20°C
solubility 
≥29.93 mg/mL in H2O; ≥43.3 mg/mL in DMSO with ultrasonic; ≥8.82 mg/mL in EtOH with ultrasonic
form 
crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16231
Product name
AT7519 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
16231
Product name
AT7519 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$104
Updated
2024/03/01
Cayman Chemical
Product number
16231
Product name
AT7519 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$174
Updated
2024/03/01
Cayman Chemical
Product number
16231
Product name
AT7519 (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$315
Updated
2024/03/01
TRC
Product number
D432100
Product name
4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylicAcidPiperidin-4-ylamideMonohydrochloride
Packaging
5mg
Price
$165
Updated
2021/12/16
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N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Chemical Properties,Usage,Production

Description

AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and <10 nM for Cdk1, 2, 4, 5, 6, and 9, respectively. It is less potent against Cdk3 and Cdk7 and inactive against non-Cdk kinases save for GSK3β (IC50 = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis, and prevents tumor growth in human tumor xenograft models. AT7519 induces activation of GSK3β by down-regulating GSK3β phosphorylation, which contributes to AT7519-induced apoptosis.

Uses

4-(2,6-DichlorobenzoylaMino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylaMide Monohydrochloride is used in the structure based design of a cyclin-dependant kinase CDK2 inhibitor.

Uses

4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylamide is used in the structure based design of a cyclin-dependant kinase CDK2 inhibitor.

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Suppliers

Canada 1 China 110 Germany 1 India 1 United Kingdom 2 United States 17 Global 132
Wuhan Acumen Bio-Technology Co.,ltd
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027-027-16602739303 16602739303
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673003916@qq.com
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China
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Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
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China
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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NCE Biomedical Co.,Ltd.
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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SYN|thesis med chem P/L
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+86-021-50720296
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+86-021-50720297
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service@synkinase.com
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China
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Moltt Biocem Co., Ltd.
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+86-21-38682181 15900741819
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+86-21-38682181
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View Lastest Price from N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl 902135-91-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Career Henan Chemical Co
Product
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl 902135-91-5
Price
US $1.00/ASSAYS
Min. Order
100ASSAYS
Purity
98%min
Supply Ability
G/KG/T
Release date
2019-12-20

902135-91-5, N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide HclRelated Search:

4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl1H-pyrazole-3-carboxamide N-Methylpiperidine Fatostatin A XL-647 BMS 777607 Fatostatin A TMC-207

  • N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
  • AT7519;AT-7519;AT 7519 HYDROCHLORIDE;AT-7519 HYDROCHLORIDE
  • 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl
  • CS-266
  • AT7519; AT-7519
  • AT 7519
  • N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride
  • AT7519 (Hydrochloride)
  • Light yellow solid
  • 4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylamide Monohydrochloride
  • AT 7519 N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride
  • AT 7519 HCl salt
  • AT7519 HCl
  • AT-7519(HCI)
  • AT7519 HCl, >=99%
  • AT 7519 hydrochloride salt
  • 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide hydrochloride
  • AT-7519 diHCl
  • 902135-91-5
  • C16H17Cl2N5O2HCl
  • C16H18Cl3N5O2
  • C16H17Cl2N5O2ClH
  • Inhibitors