ChemicalBook > CAS DataBase List > N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl

Product Name: N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
CAS No.: 902135-91-5
Chemical Name: N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
Synonyms: CS-266;AT 7519;AT7519 HCl;AT-7519(HCI);AT-7519 diHCl;AT7519; AT-7519;AT 7519 HCl salt;AT7519 HCl, >=99%;AT7519 HCl ，S7808;Light yellow solid
CBNumber: CB52473801
Molecular Formula: C16H18Cl3N5O2
Formula Weight: 418.7
MOL File: 902135-91-5.mol

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N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Property

storage temp.: Store at -20°C
solubility: ≥29.93 mg/mL in H2O; ≥43.3 mg/mL in DMSO with ultrasonic; ≥8.82 mg/mL in EtOH with ultrasonic
form: crystalline solid
color: White to off-white
InChI: InChI=1S/C16H17Cl2N5O2.ClH/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9;/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24);1H
InChIKey: PAOFPNGYBWGKCO-UHFFFAOYSA-N
SMILES: N(C1=CNN=C1C(=O)NC1CCNCC1)C(C1C(=CC=CC=1Cl)Cl)=O.Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16231
Product name: AT7519 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16231
Product name: AT7519 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $104
Updated: 2024/03/01

Cayman Chemical

Product number: 16231
Product name: AT7519 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $174
Updated: 2024/03/01

Cayman Chemical

Product number: 16231
Product name: AT7519 (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $315
Updated: 2024/03/01

TRC

Product number: D432100
Product name: 4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylicAcidPiperidin-4-ylamideMonohydrochloride
Packaging: 5mg
Price: $165
Updated: 2021/12/16

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N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Chemical Properties,Usage,Production

Description

AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC₅₀ values of 210, 47, 100, 13, 170, and <10 nM for Cdk1, 2, 4, 5, 6, and 9, respectively. It is less potent against Cdk3 and Cdk7 and inactive against non-Cdk kinases save for GSK3β (IC₅₀ = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC₅₀s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis, and prevents tumor growth in human tumor xenograft models. AT7519 induces activation of GSK3β by down-regulating GSK3β phosphorylation, which contributes to AT7519-induced apoptosis.

Uses

4-(2,6-DichlorobenzoylaMino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylaMide Monohydrochloride is used in the structure based design of a cyclin-dependant kinase CDK2 inhibitor.

Uses

4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylamide is used in the structure based design of a cyclin-dependant kinase CDK2 inhibitor.

in vivo

AT7519 inhibits tumor growth in a human MM xenograft mouse model^[1]. AT7519 (4.6 and 9.1 mg/kg/dose) inhibits the growth of early-stage HCT116 tumor xenografts. AT7519 (10 mg/kg, i.p.) also inhibits the target CDKs in HCT116 tumor-bearing BALB/c nude mice^[2].

IC 50

CDK9/Cyclin T: 10 nM (IC₅₀); CDK5/p35: 13 nM (IC₅₀); cdk2/cyclin A: 47 nM (IC₅₀); Cdk4/cyclin D1: 100 nM (IC₅₀); cdk6/cyclin D3: 170 nM (IC₅₀); Cdk1/cyclin B: 210 nM (IC₅₀); CDK7/Cyclin H/MAT1: 2400 nM (IC₅₀); GSK3β: 89 nM (IC₅₀)

References

[1] MATTHEW S SQUIRES. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines.[J]. Molecular Cancer Therapeutics, 2009, 8 2: 324-332. DOI: 10.1158/1535-7163.mct-08-0890
[2] L SANTO. AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition[J]. Oncogene, 2010, 29 16: 2325-2336. DOI: 10.1038/onc.2009.510

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl 902135-91-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Career Henan Chemical Co

Product: N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl 902135-91-5
Price: US $1.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 98%min
Supply Ability: G/KG/T
Release date: 2019-12-20

902135-91-5, N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide HclRelated Search:

4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl1H-pyrazole-3-carboxamide N-Methylpiperidine Fatostatin A XL-647 BMS 777607 Fatostatin A TMC-207

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl

AT7519;AT-7519;AT 7519 HYDROCHLORIDE;AT-7519 HYDROCHLORIDE

4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl

CS-266

AT7519; AT-7519

AT 7519

N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride

AT7519 (Hydrochloride)

Light yellow solid

4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylamide Monohydrochloride

AT 7519 N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride

AT 7519 HCl salt

AT7519 HCl

AT-7519(HCI)

AT7519 HCl, >=99%

AT 7519 hydrochloride salt

4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide hydrochloride

AT-7519 diHCl

AT7519 Hydrochloride, 10 mM in DMSO

AT7519 HCl ，S7808

902135-91-5

C16H17Cl2N5O2HCl

C16H18Cl3N5O2

C16H17Cl2N5O2ClH

Inhibitors