ChemicalBook > CAS DataBase List > Fatostatin A

Fatostatin A

Product Name
Fatostatin A
CAS No.
125256-00-0
Chemical Name
Fatostatin A
Synonyms
125B11;2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole;Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-;4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole;mice,125B11,prostate,cancer,Fatty Acid Synthase (FASN),gene,human,insulin-induced,Fatostatin,ob/ob,inhibit,expression,Golgi,Inhibitor,adipogenesis,SREBP-mediated
CBNumber
CB92627880
Molecular Formula
C18H18N2S
Formula Weight
294.41
MOL File
125256-00-0.mol
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Fatostatin A Property

Boiling point:
474.3±55.0 °C(Predicted)
Density 
1.125±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in DMSO (up to 25 mg/ml).
pka
3.46±0.10(Predicted)
form 
solid
color 
Yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5810
Product name
Fatostatin
Packaging
5mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-5810
Product name
Fatostatin
Packaging
10mg
Price
$78
Updated
2021/12/16
ChemScene
Product number
CS-5810
Product name
Fatostatin
Packaging
50mg
Price
$245
Updated
2021/12/16
ChemScene
Product number
CS-5810
Product name
Fatostatin
Packaging
100mg
Price
$420
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0013907
Product name
FATOSTATIN A
Purity
95.00%
Packaging
5MG
Price
$498.17
Updated
2021/12/16
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Fatostatin A Chemical Properties,Usage,Production

Description

Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice.1?Inhibits high glucose-induced TGF-β in mesangial cells.2?Cell permeable.

Uses

Fatostatin A is Cell permeable inhibitor of SREBP activation.

Definition

ChEBI: 4-(4-methylphenyl)-2-(2-propyl-4-pyridinyl)thiazole is a member of thiazoles.

References

1) Kamisuki et al. (2009), A small molecule that blocks fat synthesis by inhibiting the activation of SREBP; Chem. Biol., 16 882 2) Uttarwar et al. (2012), SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells; Am. J. Physiol. Renal Physiol., 302 F329

Fatostatin A Preparation Products And Raw materials

Raw materials

Preparation Products

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125256-00-0, Fatostatin ARelated Search:

EPA METYRAPONE Ginkgolide B Palmitoylethanolamide XL-647 N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl BMS 777607 Fatostatin A TMC-207

  • 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole
  • 125B11
  • Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-
  • 2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole
  • mice,125B11,prostate,cancer,Fatty Acid Synthase (FASN),gene,human,insulin-induced,Fatostatin,ob/ob,inhibit,expression,Golgi,Inhibitor,adipogenesis,SREBP-mediated
  • 125256-00-0