DIBENZAZEPINE

ChemicalBook > CAS DataBase List > DIBENZAZEPINE

Product Name: DIBENZAZEPINE
CAS No.: 209984-56-5
Chemical Name: DIBENZAZEPINE
Synonyms: GSI-XX;CS-366;YO01027;DIBENZAZEPINE;Deshydroxy LY-411575;6-Chloro-α-Tetralone;YO-01027, 10 mM in DMSO;YO-01027 (Dibenzazepine);γ-Secretase Inhibitor XX;Dibenzazepine (YO-01027)
CBNumber: CB11234300
Molecular Formula: C26H23F2N3O3
Formula Weight: 463.48
MOL File: 209984-56-5.mol

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DIBENZAZEPINE Property

Melting point:: 257-259?C
Boiling point:: 801.3±65.0 °C(Predicted)
Density: 1.35
storage temp.: -20°C
solubility: DMSO: soluble15mg/mL, clear
pka: 12.76±0.20(Predicted)
form: White solid
color: white to beige
optical activity: [α]/D -128.0 to -154.0°-0.25 in methanol
InChIKey: QSHGISMANBKLQL-OWJWWREXSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 565789
Product name: γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem
Purity: This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model.
Packaging: 500μg
Price: $417
Updated: 2024/03/01

Sigma-Aldrich

Product number: 565789
Product name: γ-Secretase Inhibitor XX
Packaging: 1mg
Price: $532
Updated: 2024/03/01

Alfa Aesar

Product number: J64904
Product name: gamma-Secretase Inhibitor XX
Packaging: 3mg
Price: $761
Updated: 2023/06/20

Cayman Chemical

Product number: 14627
Product name: DBZ
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 14627
Product name: DBZ
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

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DIBENZAZEPINE Chemical Properties,Usage,Production

Description

γ-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Aβ), a 39- to 42-amino acid peptide which forms the amyloid plaques that are characteristic of Alzheimer’s disease. DBZ is a dipeptidic inhibitor of γ-secretase that potently blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC₅₀ = 1.7 nM). Within 4 hours after a single 100 μM/kg dose, DBZ demonstrates anti-Alzheimer activity in an APP transgenic mouse model characterized by high levels of Aβ40 by reducing Aβ40 levels by 71%.

Chemical Properties

White Solid

Uses

γ-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Aβ), a 39- to 42-amino acid peptide which forms the amyloid plaques that are characteristic of Alzheimer’s disease. DBZ is a dipeptidic inhibitor of γ-secretase that potently blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC50 = 1.7 nM). Within 4 hours after a single 100 μM/kg dose, DBZ demonstrates anti-Alzheimer activity in an APP transgenic mouse model characterized by high levels of Aβ40 by reducing Aβ40 levels by 71%.

Uses

DIBENZAZEPINE is a dipeptidic-secretase inhibitor and a antiAlzheimer agent.

Uses

A dipeptidic γ-secretase inhibitor. AntiAlzheimer agent.

General Description

A cell-permeable, potent γ-secretase inhibitor that significantly lowers both brain and plasma Aβ₄₀ levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 μmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC₅₀ = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and Apc^Min mouse models (10 μmol/kg, i.p).

Biochem/physiol Actions

Cell permeable: yes

target

APPL

storage

-20°C

DIBENZAZEPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DIBENZAZEPINE manufacturers

Career Henan Chemical Co

Product: DIBENZAZEPINE 209984-56-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 200kg
Release date: 2020-03-05

209984-56-5, DIBENZAZEPINERelated Search:

BETA-SECRETASE INHIBITOR IV DAPM GAMMA-SECRETASE INHIBITOR γ-Secretase Inhibitor XXI FLI-06 Semagacestat DAPT LY411575 RO4929097 MK-0752

DIBENZAZEPINE

N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide

Dibenzazepine (Deshydroxy LY 411575)

YO01027

γ-Secretase Inhibitor XX

YO-01027/Dibenzazepine/LY 411575

(2S)-2-[2-(3,5-Difluorophenyl)acetaMide]-N-[(7S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[B,D]azepin-7-

(S)-2-(2-(3,5-Difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7

YO-01027 (Dibenzazepine)

(S)-2-(2-(3,5-Difluorophenyl)acetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepi

Dibenzazepine (deshydroxy LY 411575) DBZ

Dibenzazepine (YO-01027)

Dibenzazepine, 98%, γ-secretase inhibitor

7-(S)-[N'(3,5-difluorophenylacetyl)-L-alaninyl]amino-5-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one

(S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide

Deshydroxy LY-411575

GSI-XX

γ-Secretase Inhibitor DBZ

YO-01027; YO01027; DIBENZAZEPINE; DESHYDROXY LY 411575;DBZ

CS-366

DBZ, γ-Secretase Inhibitor

γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem

YO-01027 (Dibenzazepine, DBZ)

gamma-Secretase Inhibitor XX

Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-

6-Chloro-α-Tetralone

γ-secretase,YO 01027,Gamma secretase,Notch,YO-01027,inhibit,YO01027,Inhibitor

Dibenzazepine，LY-411575/Deshydroxy LY-411575

YO-01027, 10 mM in DMSO

209984-56-5

C26H23F2N3O3

Inhibitor

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

A dipeptidic (c)-secretase inhibitor and anti-Alzheimer agent.

All Inhibitors