γ-Secretase Inhibitor XXI

Product Name: γ-Secretase Inhibitor XXI
CAS No.: 209986-17-4
Chemical Name: γ-Secretase Inhibitor XXI
Synonyms: DuPont E;Compound E, gamma;-secretase inhibitor;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor XXI;g-Secretase Inhibitor XXI;γ-Secretase Inhibitor XXI;CoMpound E (secretase inhibitor);Compound E (γ-Secretase Inhibitor XXI)
CBNumber: CB42602844
Molecular Formula: C27H24F2N4O3
Formula Weight: 490.5
MOL File: 209986-17-4.mol

More

Less

γ-Secretase Inhibitor XXI Property

Boiling point:: 778.6±60.0 °C(Predicted)
Density: 1.31
storage temp.: = -70C
solubility: Soluble in DMSO
form: Liquid
pka: 12.54±0.40(Predicted)
color: White to off-white
Sensitive: Light Sensitive

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 565790
Product name: γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem
Purity: Thisg-secretaseinhibitor,CAS209986-17-4,isacell-permeable,potent,select
Packaging: 500μg
Price: $345
Updated: 2024/03/01

Sigma-Aldrich

Product number: 565790
Product name: γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem
Packaging: 1mg
Price: $445
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.30509
Product name: StemSelect Compound E - CAS 209986-17-4 - Calbiochem
Packaging: 250μg
Price: $209
Updated: 2024/03/01

Alfa Aesar

Product number: J65131
Product name: Compound E
Packaging: 0.5mg
Price: $307
Updated: 2023/06/20

Cayman Chemical

Product number: 15579
Product name: Compound E
Purity: ≥98%
Packaging: 500μg
Price: $189
Updated: 2024/03/01

More

Less

γ-Secretase Inhibitor XXI Chemical Properties,Usage,Production

Uses

A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of -secretase and Notch processing

Definition

ChEBI: Compound E is an L-alanine derivative that is the amide obtained by formal condensation of the carboxy group of N-[(3,5-difluorophenyl)acetyl]-L-alanine with the amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one. An inhibitor of memapsin 2 (gamma-secretase). It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a 1,4-benzodiazepinone, a L-alanine derivative and a difluorobenzene.

storage

+4°C

γ-Secretase Inhibitor XXI Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

γ-Secretase Inhibitor XXI Suppliers

China 45 United Kingdom 2 United States 11 Global 58

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com
Country: China
ProdList: 2867
Advantage: 52

Shanghai SunSyn Pharmaceutical Co., Ltd.

Tel: -2408801818 18621020637
Email: sales@sunsynpharma.com
Country: China
ProdList: 293
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17982
Advantage: 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4121
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2982
Advantage: 58

Alabiotech Inc.

Tel: 001-619-354-5251
Fax: 001-855-855-6087
Email: sales@alabiotech-e.com
Country: United States
ProdList: 972
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9445
Advantage: 58

209986-17-4, γ-Secretase Inhibitor XXIRelated Search:

BETA-SECRETASE INHIBITOR IV DAPM GAMMA-SECRETASE INHIBITOR DIBENZAZEPINE Sulfanilamide Deionized water N,N'-Ethylenebis(stearamide) 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol DAPT

γ-Secretase Inhibitor XXI

N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide

CoMpound E (secretase inhibitor)

DuPont E

g-Secretase Inhibitor XXI

γ-Secretase Inhibitor BZ

(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide

(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide

StemSelect Compound E - CAS 209986-17-4 - Calbiochem

BZ, γ-Secretase Inhibitor - Compound E

Compound E (γ-Secretase Inhibitor XXI)

Benzeneacetamide, N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-

γ-Secretase Inhibitor BZ

γ-Secretase Inhibitor XXI

Compound E, gamma

-secretase inhibitor

209986-17-4

C27H24F2N4O3